| 1 | Mon Nov 4 | vs McNeese | W80-73 | 1-0 | 1.000 | - | | Frost Arena · Brookings, SD |
| 2 | Fri Nov 8 | vs Long Beach St | W80-79 | 2-0 | 1.000 | - | | Frost Arena · Brookings, SD |
| 3 | Thu Nov 14 | vs N Colorado | L69-78 | 2-1 | .667 | - | | Frost Arena · Brookings, SD |
| 4 | Mon Nov 18 | vs TBD | W89-41 | 3-1 | .750 | - | | Frost Arena · Brookings, SD |
| 5 | Wed Nov 20 | vs Southern Miss | W101-76 | 4-1 | .800 | - | | Frost Arena · Brookings, SD |
| 6 | Sun Nov 24 | at Duquesne | W71-60 | 5-1 | .833 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Mon Nov 25 | vs Boise St | L82-83 | 5-2 | .714 | - | | Frost Arena · Brookings, SD |
| 8 | Tue Nov 26 | at Missouri St | W75-55 | 6-2 | .750 | - | | Great Southern Bank Arena · Springfield, MO |
| 9 | Mon Dec 2 | vsTBD | W78-62 | 7-2 | .778 | - | | Frost Arena · Brookings, SD |
| 10 | Wed Dec 4 | at Montana | L67-71 | 7-3 | .700 | - | ESPN+ | Dahlberg Arena · Missoula, MT |
| 11 | Sat Dec 7 | vs E Washington | W74-53 | 8-3 | .727 | - | | Frost Arena · Brookings, SD |
| 12 | Wed Dec 11 | at Nevada | L63-77 | 8-4 | .667 | - | | Lawlor Events Center · Reno, NV |
| 13 | Fri Dec 13 | at Colorado | L70-81 | 8-5 | .615 | - | ESPN+ | CU Events Center · Boulder, CO |
| 14 | Thu Dec 19 | vsTBD | W87-72 | 9-5 | .643 | - | | Frost Arena · Brookings, SD |
| 15 | Sun Dec 29 | at #5Alabama | L82-105 | 9-6 | .600 | - | ESPN+ | Coleman Coliseum · Tuscaloosa, AL |
| 16 | Thu Jan 2 | vs Denver | W91-70 | 10-6 | .625 | - | CBS | Frost Arena · Brookings, SD |
| 17 | Wed Jan 8 | at St Thomas (MN) | L72-73 | 10-7 | .588 | - | | Schoenecker Arena · Saint Paul, MN |
| 18 | Sat Jan 11 | at Omaha | L80-87 | 10-8 | .556 | - | | Baxter Arena · Omaha, NE |
| 19 | Thu Jan 16 | vs North Dakota | W109-73 | 11-8 | .579 | - | | Frost Arena · Brookings, SD |
| 20 | Sat Jan 18 | vs Oral Roberts | W84-70 | 12-8 | .600 | - | | Frost Arena · Brookings, SD |
| 21 | Thu Jan 23 | at Kansas City | W65-64 | 13-8 | .619 | - | | Swinney Recreation Center · Kansas City, MO |
| 22 | Sat Jan 25 | vs South Dakota | W90-71 | 14-8 | .636 | - | | Frost Arena · Brookings, SD |
| 23 | Thu Jan 30 | at N Dakota St | W72-62 | 15-8 | .652 | - | | Scheels Center · Fargo, ND |
| 24 | Sat Feb 1 | atNorth Dakota | L75-80 | 15-9 | .625 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 25 | Thu Feb 6 | vsSt Thomas (MN) | W102-86 | 16-9 | .640 | - | | Frost Arena · Brookings, SD |
| 26 | Thu Feb 13 | vsOmaha | W98-85 | 17-9 | .654 | - | | Frost Arena · Brookings, SD |
| 27 | Sun Feb 16 | atSouth Dakota | W94-91 | 18-9 | .667 | - | CBS | Sanford Coyote Sports Center · Vermillion, SD |
| 28 | Wed Feb 19 | vsN Dakota St | L68-77 | 18-10 | .643 | - | | Frost Arena · Brookings, SD |
| 29 | Sun Feb 23 | vsKansas City | W70-65 | 19-10 | .655 | - | CBS | Frost Arena · Brookings, SD |
| 30 | Thu Feb 27 | atOral Roberts | W77-69 | 20-10 | .667 | - | | Mabee Center · Tulsa, OK |
| 31 | Sat Mar 1 | atDenver | L62-78 | 20-11 | .645 | - | | Hamilton Gymnasium · Denver, CO |
| 32 | Fri Mar 7 | vsNorth Dakota | L69-85 | 20-12 | .625 | - | | Frost Arena · Brookings, SD |
