| 1 | Tue Nov 5 | vs UT Rio Grande | W70-57 | 1-0 | 1.000 | - | | Frost Arena · Brookings, SD |
| 2 | Thu Nov 7 | vs TBD | W86-58 | 2-0 | 1.000 | - | | Frost Arena · Brookings, SD |
| 3 | Sat Nov 9 | at Bakersfield | W93-91 (2OT) | 3-0 | 1.000 | - | | Icardo Center · Bakersfield, CA |
| 4 | Tue Nov 12 | at USC | L66-84 | 3-1 | .750 | - | | Galen Center · Los Angeles, CA |
| 5 | Fri Nov 15 | at Nebraska | L73-90 | 3-2 | .600 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 6 | Tue Nov 19 | vs North Alabama | W78-73 | 4-2 | .667 | - | | Frost Arena · Brookings, SD |
| 7 | Thu Nov 21 | at #14Arizona | L64-71 | 4-3 | .571 | - | PACN | McKale Center · Tucson, AZ |
| 8 | Sun Nov 24 | vs Miss Valley St | W84-54 | 5-3 | .625 | - | | Frost Arena · Brookings, SD |
| 9 | Wed Nov 27 | vs Samford | W86-77 | 6-3 | .667 | - | | Frost Arena · Brookings, SD |
| 10 | Sat Nov 30 | at Indiana | L50-64 | 6-4 | .600 | - | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 11 | Thu Dec 5 | at Montana St | L70-77 | 6-5 | .545 | - | | Worthington Arena · Bozeman, MT |
| 12 | Tue Dec 10 | at Colorado St | L68-72 | 6-6 | .500 | - | | Moby Arena · Fort Collins, CO |
| 13 | Fri Dec 13 | vsTBD | W66-53 | 7-6 | .538 | - | | Frost Arena · Brookings, SD |
| 14 | Wed Dec 18 | vs FGCU | W75-56 | 8-6 | .571 | - | | Frost Arena · Brookings, SD |
| 15 | Sat Dec 21 | vs Idaho | W85-57 | 9-6 | .600 | - | | Frost Arena · Brookings, SD |
| 16 | Sun Dec 29 | at Omaha | L78-81 | 9-7 | .563 | - | | Baxter Arena · Omaha, NE |
| 17 | Thu Jan 2 | vs Oral Roberts | W96-79 | 10-7 | .588 | - | | Frost Arena · Brookings, SD |
| 18 | Sat Jan 4 | vs W Illinois | W91-56 | 11-7 | .611 | - | | Frost Arena · Brookings, SD |
| 19 | Wed Jan 8 | at Denver | W80-68 | 12-7 | .632 | - | | Hamilton Gymnasium · Denver, CO |
| 20 | Sat Jan 11 | at Purdue FW | W70-61 | 13-7 | .650 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 21 | Wed Jan 15 | vs North Dakota | W87-66 | 14-7 | .667 | - | | Frost Arena · Brookings, SD |
| 22 | Sun Jan 19 | at South Dakota | L84-99 | 14-8 | .636 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 23 | Wed Jan 22 | vs N Dakota St | W78-73 | 15-8 | .652 | - | | Frost Arena · Brookings, SD |
| 24 | Wed Jan 29 | atOral Roberts | W76-61 | 16-8 | .667 | - | | Mabee Center · Tulsa, OK |
| 25 | Sat Feb 1 | atW Illinois | W71-61 | 17-8 | .680 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 26 | Sat Feb 8 | vsOmaha | W81-64 | 18-8 | .692 | - | | Frost Arena · Brookings, SD |
| 27 | Fri Feb 14 | vsDenver | W90-78 | 19-8 | .704 | - | | Frost Arena · Brookings, SD |
| 28 | Sun Feb 16 | vsPurdue FW | W75-64 | 20-8 | .714 | - | | Frost Arena · Brookings, SD |
| 29 | Wed Feb 19 | atNorth Dakota | W94-83 | 21-8 | .724 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 30 | Sun Feb 23 | vsSouth Dakota | W85-80 | 22-8 | .733 | - | | Frost Arena · Brookings, SD |
| 31 | Thu Feb 27 | atN Dakota St | L69-71 (OT) | 22-9 | .710 | - | | Scheels Center · Fargo, ND |
| 32 | Sat Mar 7 | vsPurdue FW | L74-77 | 22-10 | .688 | - | | Frost Arena · Brookings, SD |
