| 1 | Mon Nov 4 | at UNC Greensboro | L64-73 | 0-1 | .000 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 2 | Fri Nov 8 | at TCU | L51-67 | 0-2 | .000 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 3 | Wed Nov 13 | vs St Bonaventure | L65-74 | 0-3 | .000 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 4 | Sat Nov 16 | at Drake | L61-63 | 0-4 | .000 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 5 | Fri Nov 22 | vs Bakersfield | W74-54 | 1-4 | .200 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 6 | Sat Nov 23 | vs Northeastern | L55-59 | 1-5 | .167 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 7 | Sun Nov 24 | vs FIU | W60-59 | 2-5 | .286 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 8 | Sat Nov 30 | at FAU | W80-78 | 3-5 | .375 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 9 | Wed Dec 4 | vs Furman | L73-76 | 3-6 | .333 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 10 | Sun Dec 8 | at LSU | L71-80 | 3-7 | .300 | - | ESPN+ | Pete Maravich Assembly Center · Baton Rouge, LA |
| 11 | Wed Dec 18 | at UNC Wilmington | L66-79 | 3-8 | .273 | - | | Trask Coliseum · Wilmington, NC |
| 12 | Sun Dec 22 | vs TBD | W79-62 | 4-8 | .333 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 13 | Sat Dec 28 | at Richmond | W75-57 | 5-8 | .385 | - | ESPN+ | Robins Center · Richmond, VA |
| 14 | Thu Jan 2 | at W Georgia | W79-68 | 6-8 | .429 | - | ESPN+ | The Coliseum · Carrollton, GA |
| 15 | Sat Jan 4 | at Queens | L83-92 | 6-9 | .400 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 16 | Thu Jan 9 | vs North Alabama | W75-70 | 7-9 | .438 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 17 | Sat Jan 11 | vs C Arkansas | W77-71 | 8-9 | .471 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 18 | Thu Jan 16 | vsW Georgia | W82-60 | 9-9 | .500 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 19 | Sat Jan 18 | vsQueens | W60-47 | 10-9 | .526 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 20 | Thu Jan 23 | at Bellarmine | W77-61 | 11-9 | .550 | - | ESPN+ | Knights Hall · Louisville, KY |
| 21 | Sat Jan 25 | at E Kentucky | L77-81 | 11-10 | .524 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 22 | Wed Jan 29 | at Jacksonville | W83-79 | 12-10 | .545 | - | ESPN+ | Swisher Gymnasium · Jacksonville, FL |
| 23 | Sat Feb 1 | vs Stetson | W82-56 | 13-10 | .565 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 24 | Thu Feb 6 | vsE Kentucky | L74-92 | 13-11 | .542 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 25 | Sat Feb 8 | at North Florida | W84-70 | 14-11 | .560 | - | ESPN+ | UNF Arena · Jacksonville, FL |
| 26 | Thu Feb 13 | at Austin Peay | L60-73 | 14-12 | .538 | - | ESPN+ | Winfield Dunn Center · Clarksville, TN |
| 27 | Sat Feb 15 | at Lipscomb | L68-82 | 14-13 | .519 | - | ESPN+ | Allen Arena · Nashville, TN |
| 28 | Tue Feb 18 | vsJacksonville | W72-56 | 15-13 | .536 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 29 | Thu Feb 20 | atStetson | W83-80 | 16-13 | .552 | - | ESPN+ | Edmunds Center · Deland, FL |
| 30 | Mon Feb 24 | vsNorth Florida | W86-82 | 17-13 | .567 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 31 | Wed Feb 26 | vsBellarmine | W80-61 | 18-13 | .581 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 32 | Mon Mar 3 | vsQueens | L65-71 | 18-14 | .563 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 33 | Mon Mar 24 | vs Army | W68-65 | 19-14 | .576 | - | | Alico Arena · Fort Myers, FL |
| 34 | Tue Mar 25 | at Cleveland St | L65-72 | 19-15 | .559 | - | ESPN2 | Wolstein Center · Cleveland, OH |
