| 1 | Mon Nov 3 | vs Indiana St | W92-76 | 1-0 | 1.000 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 2 | Fri Nov 7 | vsTennessee Tech | W70-65 | 2-0 | 1.000 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 3 | Tue Nov 11 | vsDavidson | L55-62 | 2-1 | .667 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 4 | Sun Nov 16 | atVirginia Tech | L76-84 | 2-2 | .500 | - | ACC Extra | Cassell Coliseum · Blacksburg, VA |
| 5 | Fri Nov 21 | atAppalachian St | L63-65 | 2-3 | .400 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
| 6 | Sun Nov 23 | vsTBD | W83-79 | 3-3 | .500 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 7 | Thu Nov 27 | atIllinois St | L69-79 | 3-4 | .429 | - | ESPN2 | Redbird Arena · Normal, IL |
| 8 | Fri Nov 28 | vsRichmond | L66-71 | 3-5 | .375 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 9 | Tue Dec 2 | vsNC A&T | W74-57 | 4-5 | .444 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 10 | Sun Dec 7 | vsUtah State | L53-79 | 4-6 | .400 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 11 | Sun Dec 14 | atCharleston | L67-74 | 4-7 | .364 | - | | TD Arena · Charleston, SC |
| 12 | Thu Dec 18 | vsLafayette | W81-67 | 5-7 | .417 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 13 | Sun Dec 21 | vsUIC | W88-76 (OT) | 6-7 | .462 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 14 | Tue Dec 30 | vsTemple | L73-76 | 6-8 | .429 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 15 | Sat Jan 3 | vsWichita St | W104-100 (2OT) | 7-8 | .467 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 16 | Wed Jan 7 | atUTSA | W74-58 | 8-8 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 17 | Sun Jan 11 | atRice | W74-73 | 9-8 | .529 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 18 | Wed Jan 14 | vsTulsa | L74-86 | 9-9 | .500 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 19 | Sun Jan 18 | atE Carolina | W73-70 | 10-9 | .526 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 20 | Fri Jan 23 | vsTulane | W73-70 | 11-9 | .550 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 21 | Wed Jan 28 | atTemple | W80-76 (OT) | 12-9 | .571 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 22 | Fri Jan 30 | vsRice | W80-70 | 13-9 | .591 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 23 | Wed Feb 4 | atWichita St | L64-74 | 13-10 | .565 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 24 | Sun Feb 8 | atMemphis | L54-77 | 13-11 | .542 | - | ESPN+ | FedExForum · Memphis, TN |
| 25 | Sun Feb 15 | vsUTSA | L79-88 | 13-12 | .520 | - | ESPNU | Dale F. Halton Arena · Charlotte, NC |
| 26 | Wed Feb 18 | atTulsa | L74-79 | 13-13 | .500 | - | ESPN+ | Donald W. Reynolds Center · Tulsa, OK |
| 27 | Sat Feb 21 | vsE Carolina | W68-56 | 14-13 | .519 | - | ESPN2 | Dale F. Halton Arena · Charlotte, NC |
| 28 | Wed Feb 25 | vsNorth Texas | W80-79 | 15-13 | .536 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 29 | Sun Mar 1 | atFAU | L76-77 (OT) | 15-14 | .517 | - | ESPN+ | FAU Arena · Boca Raton, FL |
