| 1 | Mon Nov 4 | vs TBD | W100-61 | 1-0 | 1.000 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 2 | Fri Nov 8 | at Queens | L54-67 | 1-1 | .500 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 3 | Wed Nov 13 | vsTBD | W99-64 | 2-1 | .667 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 4 | Tue Nov 19 | at Wake Forest | L69-82 | 2-2 | .500 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 5 | Tue Nov 26 | at Florida St | L57-91 | 2-3 | .400 | - | ESPN+ | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Sat Nov 30 | at #10Marquette | L62-94 | 2-4 | .333 | - | FS2 | Fiserv Forum · Milwaukee, WI |
| 7 | Wed Dec 4 | vs Bellarmine | W86-74 | 3-4 | .429 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 8 | Sat Dec 7 | vs SC Upstate | L68-74 | 3-5 | .375 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 9 | Sat Dec 14 | at UNC Asheville | L61-78 | 3-6 | .333 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 10 | Tue Dec 17 | at #1Tennessee | L36-84 | 3-7 | .300 | - | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 11 | Thu Dec 19 | vsTBD | W78-69 | 4-7 | .364 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 12 | Wed Jan 1 | vs Furman | L61-90 | 4-8 | .333 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 13 | Sat Jan 4 | vs Samford | L69-88 | 4-9 | .308 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 14 | Wed Jan 8 | at Wofford | L69-77 | 4-10 | .286 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 15 | Sun Jan 12 | vs Mercer | W85-82 | 5-10 | .333 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 16 | Wed Jan 15 | at VMI | L50-66 | 5-11 | .313 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 17 | Sat Jan 18 | vs UNC Greensboro | L55-83 | 5-12 | .294 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 18 | Wed Jan 22 | at ETSU | L58-85 | 5-13 | .278 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 19 | Sat Jan 25 | at The Citadel | W80-78 (OT) | 6-13 | .316 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 20 | Wed Jan 29 | vs Chattanooga | L60-84 | 6-14 | .300 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 21 | Sat Feb 1 | vsVMI | L76-80 (OT) | 6-15 | .286 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 22 | Wed Feb 5 | atFurman | L75-84 (OT) | 6-16 | .273 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 23 | Sat Feb 8 | atUNC Greensboro | L70-74 | 6-17 | .261 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 24 | Wed Feb 12 | vsETSU | W76-67 | 7-17 | .292 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 25 | Sat Feb 15 | vsThe Citadel | W76-73 | 8-17 | .320 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 26 | Wed Feb 19 | atChattanooga | L86-91 | 8-18 | .308 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
