| 1 | Mon Nov 3 | vs TBD | W105-61 | 1-0 | 1.000 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 2 | Thu Nov 6 | atBoston College | L47-76 | 1-1 | .500 | - | ACC Extra | Silvio O. Conte Forum · Chestnut Hill, MA |
| 3 | Mon Nov 10 | vsCharleston So | L86-96 | 1-2 | .333 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 4 | Fri Nov 14 | atW Georgia | L92-100 | 1-3 | .250 | - | ESPN+ | The Coliseum · Carrollton, GA |
| 5 | Wed Nov 19 | vsTBD | W70-57 | 2-3 | .400 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 6 | Mon Nov 24 | vsBellarmine | L58-70 | 2-4 | .333 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Wed Nov 26 | vsHou Christian | L65-72 | 2-5 | .286 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 8 | Sun Nov 30 | vsPresbyterian | L41-69 | 2-6 | .250 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 9 | Thu Dec 4 | atDavidson | L63-79 | 2-7 | .222 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 10 | Tue Dec 9 | vsTBD | W98-73 | 3-7 | .300 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 11 | Sat Dec 13 | atSouth Carolina | L55-71 | 3-8 | .273 | - | SECN+ | Colonial Life Arena · Columbia, SC |
| 12 | Wed Dec 17 | atCharleston | L78-82 | 3-9 | .250 | - | | TD Arena · Charleston, SC |
| 13 | Sat Dec 20 | atRichmond | L56-80 | 3-10 | .231 | - | ESPN+ | Robins Center · Richmond, VA |
| 14 | Tue Dec 30 | vsETSU | L49-74 | 3-11 | .214 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 15 | Sat Jan 3 | vsWofford | L86-95 | 3-12 | .200 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 16 | Wed Jan 7 | atMercer | L63-101 | 3-13 | .188 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 17 | Sat Jan 10 | vsW Carolina | W79-77 (OT) | 4-13 | .235 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 18 | Thu Jan 15 | atUNC Greensboro | L66-69 (OT) | 4-14 | .222 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 19 | Sat Jan 17 | atVMI | W82-68 | 5-14 | .263 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 20 | Wed Jan 21 | vsFurman | W77-75 (OT) | 6-14 | .300 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 21 | Fri Jan 23 | atETSU | L55-84 | 6-15 | .286 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 22 | Thu Jan 29 | vsVMI | W80-56 | 7-15 | .318 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 23 | Sat Jan 31 | vsUNC Greensboro | W71-66 (OT) | 8-15 | .348 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 24 | Thu Feb 5 | atSamford | L64-78 | 8-16 | .333 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 25 | Sat Feb 7 | atChattanooga | W78-71 | 9-16 | .360 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 26 | Wed Feb 11 | atW Carolina | L49-87 | 9-17 | .346 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 27 | Sat Feb 14 | vsMercer | L54-70 | 9-18 | .333 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 28 | Thu Feb 19 | vsSamford | L75-78 | 9-19 | .321 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 29 | Sat Feb 21 | vsChattanooga | L72-93 | 9-20 | .310 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 30 | Wed Feb 25 | atFurman | L51-72 | 9-21 | .300 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 31 | Sat Feb 28 | atWofford | W93-90 (OT) | 10-21 | .323 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
