| 1 | Mon Nov 4 | at Boston College | L60-69 | 0-1 | .000 | - | ESPN+ | Silvio O. Conte Forum · Chestnut Hill, MA |
| 2 | Thu Nov 7 | vs TBD | W86-56 | 1-1 | .500 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 3 | Mon Nov 11 | vs Stetson | W74-52 | 2-1 | .667 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 4 | Thu Nov 14 | vsTBD | W79-54 | 3-1 | .750 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 5 | Sun Nov 17 | vs NC A&T | L73-82 | 3-2 | .600 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 6 | Wed Nov 20 | vs Charleston | L61-76 | 3-3 | .500 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Tue Nov 26 | vsTBD | W100-85 | 4-3 | .571 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 8 | Tue Dec 3 | vsTBD | W94-57 | 5-3 | .625 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 9 | Thu Dec 12 | vs Campbell | L58-86 | 5-4 | .556 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 10 | Mon Dec 16 | at C Arkansas | L71-73 | 5-5 | .500 | - | ESPN+ | Farris Center · Conway, AR |
| 11 | Wed Dec 18 | at Vanderbilt | L53-105 | 5-6 | .455 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 12 | Wed Jan 1 | at Samford | L56-86 | 5-7 | .417 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 13 | Sat Jan 4 | vs Chattanooga | L68-81 | 5-8 | .385 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 14 | Wed Jan 8 | vs Furman | L63-67 (OT) | 5-9 | .357 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 15 | Sat Jan 11 | at ETSU | L52-70 | 5-10 | .333 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 16 | Wed Jan 15 | at UNC Greensboro | L57-70 | 5-11 | .313 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 17 | Sat Jan 18 | vs VMI | L70-75 | 5-12 | .294 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 18 | Wed Jan 22 | at Wofford | L68-79 | 5-13 | .278 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 19 | Sat Jan 25 | vs W Carolina | L78-80 (OT) | 5-14 | .263 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 20 | Wed Jan 29 | at Mercer | L46-80 | 5-15 | .250 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 21 | Sat Feb 1 | vsSamford | L58-83 | 5-16 | .238 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 22 | Wed Feb 5 | vsUNC Greensboro | L61-76 | 5-17 | .227 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 23 | Sat Feb 8 | atVMI | L70-82 | 5-18 | .217 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 24 | Wed Feb 12 | vsWofford | L71-74 (OT) | 5-19 | .208 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 25 | Sat Feb 15 | atW Carolina | L73-76 | 5-20 | .200 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 26 | Wed Feb 19 | vsMercer | L52-62 | 5-21 | .192 | - | ESPN+ | McAlister Field House · Charleston, SC |
