| 1 | Mon Nov 7 | at Clemson | L69-80 | 0-1 | .000 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Thu Nov 10 | vsPresbyterian | W70-58 | 1-1 | .500 | - | | McAlister Field House · Charleston, SC |
| 3 | Tue Nov 15 | vsTBD | W109-66 | 2-1 | .667 | - | | McAlister Field House · Charleston, SC |
| 4 | Sat Nov 19 | atButler | L42-89 | 2-2 | .500 | - | FS2 | Hinkle Fieldhouse · Indianapolis, IN |
| 5 | Wed Nov 23 | atNew Orleans | W72-65 | 3-2 | .600 | - | | Lakefront Arena · New Orleans, LA |
| 6 | Thu Nov 24 | atDenver | L71-74 | 3-3 | .500 | - | | Hamilton Gymnasium · Denver, CO |
| 7 | Fri Nov 25 | vsIU Indy | W74-53 | 4-3 | .571 | - | | McAlister Field House · Charleston, SC |
| 8 | Wed Nov 30 | atCharleston So | W76-73 | 5-3 | .625 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 9 | Sat Dec 3 | vsCharleston | L57-79 | 5-4 | .556 | - | | McAlister Field House · Charleston, SC |
| 10 | Tue Dec 13 | atUNC | L67-100 | 5-5 | .500 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 11 | Sat Dec 17 | vsLongwood | L70-75 | 5-6 | .455 | - | | McAlister Field House · Charleston, SC |
| 12 | Tue Dec 20 | atNC Central | L74-81 | 5-7 | .417 | - | | McDougald-McLendon Arena · Durham, NC |
| 13 | Thu Dec 29 | vsChattanooga | W76-68 | 6-7 | .462 | - | | McAlister Field House · Charleston, SC |
| 14 | Sat Dec 31 | vsSamford | L63-75 | 6-8 | .429 | - | | McAlister Field House · Charleston, SC |
| 15 | Wed Jan 4 | atFurman | L72-97 | 6-9 | .400 | - | | Timmons Arena · Greenville, SC |
| 16 | Sat Jan 7 | atWofford | L57-77 | 6-10 | .375 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Wed Jan 11 | vsETSU | L74-96 | 6-11 | .353 | - | | McAlister Field House · Charleston, SC |
| 18 | Sat Jan 14 | vsW Carolina | W65-61 | 7-11 | .389 | - | | McAlister Field House · Charleston, SC |
| 19 | Thu Jan 19 | atUNC Greensboro | L60-70 | 7-12 | .368 | - | | Greensboro Coliseum · Greensboro, NC |
| 20 | Sat Jan 21 | atVMI | W60-52 | 8-12 | .400 | - | | Cameron Hall · Lexington, VA |
| 21 | Wed Jan 25 | atW Carolina | W81-70 | 9-12 | .429 | - | | Ramsey Regional Activity Center · Cullowhee, NC |
| 22 | Sat Jan 28 | vsMercer | L65-74 | 9-13 | .409 | - | | McAlister Field House · Charleston, SC |
| 23 | Mon Jan 30 | vsChicago St | L75-76 | 9-14 | .391 | - | | McAlister Field House · Charleston, SC |
| 24 | Thu Feb 2 | vsVMI | L69-75 | 9-15 | .375 | - | | McAlister Field House · Charleston, SC |
| 25 | Sat Feb 4 | vsUNC Greensboro | L59-79 | 9-16 | .360 | - | | McAlister Field House · Charleston, SC |
| 26 | Wed Feb 8 | atChattanooga | L63-82 | 9-17 | .346 | - | | McKenzie Arena · Chattanooga, TN |
| 27 | Sat Feb 11 | atSamford | L70-76 | 9-18 | .333 | - | | Pete Hanna Center · Homewood, AL |
| 28 | Wed Feb 15 | vsFurman | W69-65 | 10-18 | .357 | - | | McAlister Field House · Charleston, SC |
| 29 | Sat Feb 18 | vsWofford | L68-72 | 10-19 | .345 | - | | McAlister Field House · Charleston, SC |
| 30 | Wed Feb 22 | atETSU | L70-78 | 10-20 | .333 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 31 | Sat Feb 25 | atMercer | L50-72 | 10-21 | .323 | - | | Hawkins Arena · Macon, GA |
| 32 | Fri Mar 3 | atMercer | L41-66 | 10-22 | .313 | - | | Hawkins Arena · Macon, GA |
