| 1 | Mon Nov 4 | at Clemson | L64-91 | 0-1 | .000 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 2 | Thu Nov 7 | at North Florida | L66-90 | 0-2 | .000 | - | ESPN+ | UNF Arena · Jacksonville, FL |
| 3 | Mon Nov 11 | vs TBD | W108-50 | 1-2 | .333 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 4 | Fri Nov 15 | vs UT Rio Grande | L76-86 | 1-3 | .250 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 5 | Sat Nov 16 | at VMI | L69-80 | 1-4 | .200 | - | | Cameron Hall · Lexington, VA |
| 6 | Tue Nov 19 | at LSU | L68-77 | 1-5 | .167 | - | ESPN+ | Pete Maravich Assembly Center · Baton Rouge, LA |
| 7 | Sat Nov 23 | vs Furman | L46-67 | 1-6 | .143 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 8 | Wed Nov 27 | at Georgia Tech | L67-91 | 1-7 | .125 | - | ESPN+ | McCamish Pavilion · Atlanta, GA |
| 9 | Sat Nov 30 | at Miami | W83-79 | 2-7 | .222 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 10 | Tue Dec 3 | vs UT Martin | W83-68 | 3-7 | .300 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 11 | Fri Dec 6 | at Davidson | L72-73 | 3-8 | .273 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 12 | Mon Dec 9 | at SC State | L63-82 | 3-9 | .250 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 13 | Thu Dec 19 | at North Alabama | L69-86 | 3-10 | .231 | - | ESPN+ | Flowers Hall · Florence, AL |
| 14 | Sun Dec 22 | at Georgia | L65-81 | 3-11 | .214 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 15 | Sat Dec 28 | vsTBD | W95-89 | 4-11 | .267 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 16 | Thu Jan 2 | vs Gardner-Webb | W72-63 | 5-11 | .313 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 17 | Sat Jan 4 | at Longwood | L78-83 | 5-12 | .294 | - | ESPN+ | Willett Hall · Farmville, VA |
| 18 | Wed Jan 8 | vs High Point | L79-93 | 5-13 | .278 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 19 | Wed Jan 15 | at Winthrop | L97-102 (3OT) | 5-14 | .263 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 20 | Sat Jan 18 | vs Radford | W58-54 | 6-14 | .300 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 21 | Wed Jan 22 | at Presbyterian | L61-71 | 6-15 | .286 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Sat Jan 25 | vs UNC Asheville | L61-69 | 6-16 | .273 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 23 | Wed Jan 29 | at SC Upstate | W82-75 | 7-16 | .304 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 24 | Sat Feb 1 | vsLongwood | W89-85 | 8-16 | .333 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 25 | Wed Feb 5 | vsWinthrop | L65-83 | 8-17 | .320 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 26 | Sat Feb 8 | atGardner-Webb | W79-72 | 9-17 | .346 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 27 | Wed Feb 12 | vsPresbyterian | W71-70 | 10-17 | .370 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 28 | Sat Feb 15 | atUNC Asheville | L72-75 | 10-18 | .357 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 29 | Wed Feb 19 | atHigh Point | L60-83 | 10-19 | .345 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
