| 1 | Mon Nov 4 | at Louisville | L45-93 | 0-1 | .000 | - | ESPN+ | KFC Yum! Center · Louisville, KY |
| 2 | Wed Nov 6 | vs TBD | W89-48 | 1-1 | .500 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 3 | Fri Nov 8 | at #20Cincinnati | L56-83 | 1-2 | .333 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 4 | Thu Nov 14 | at Chattanooga | L62-76 | 1-3 | .250 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 5 | Wed Nov 20 | vs Austin Peay | W63-58 | 2-3 | .400 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 6 | Wed Nov 27 | vs NJIT | L69-78 | 2-4 | .333 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 7 | Fri Nov 29 | at Cleveland St | W71-69 | 3-4 | .429 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 8 | Wed Dec 4 | at Marshall | L77-80 | 3-5 | .375 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 9 | Sat Dec 7 | at Ohio | L76-88 | 3-6 | .333 | - | ESPN+ | Convocation Center (OH) · Athens, OH |
| 10 | Sun Dec 15 | vsTBD | W86-63 | 4-6 | .400 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 11 | Thu Dec 19 | vs UT Martin | W70-69 (OT) | 5-6 | .455 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 12 | Sat Dec 21 | vs Tennessee St | W74-68 | 6-6 | .500 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 13 | Sat Dec 28 | vsTBD | W94-63 | 7-6 | .538 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 14 | Tue Dec 31 | at So Indiana | W70-68 | 8-6 | .571 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 15 | Sat Jan 4 | at Tennessee Tech | L55-74 | 8-7 | .533 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 16 | Thu Jan 9 | at Little Rock | W59-53 | 9-7 | .563 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
| 17 | Sat Jan 11 | at SE Missouri St | W67-56 | 10-7 | .588 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 18 | Thu Jan 16 | vs W Illinois | W51-47 | 11-7 | .611 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 19 | Sat Jan 18 | vs Lindenwood | W82-65 | 12-7 | .632 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 20 | Thu Jan 23 | at E Illinois | W73-66 | 13-7 | .650 | - | ESPNU | Lantz Arena · Charleston, IL |
| 21 | Sat Jan 25 | at SIUE | L54-65 | 13-8 | .619 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Tue Jan 28 | vsSo Indiana | W66-65 | 14-8 | .636 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 23 | Thu Jan 30 | vsTennessee Tech | L64-72 | 14-9 | .609 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 24 | Thu Feb 6 | vsSE Missouri St | L51-80 | 14-10 | .583 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 25 | Sat Feb 8 | vsLittle Rock | L62-76 | 14-11 | .560 | - | ESPNU | Ellis T. Johnson Arena · Morehead, KY |
| 26 | Thu Feb 13 | atLindenwood | L60-73 | 14-12 | .538 | - | ESPN+ | placeholder · sf, ca |
| 27 | Sat Feb 15 | atW Illinois | L67-72 | 14-13 | .519 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 28 | Thu Feb 20 | vsSIUE | L62-80 | 14-14 | .500 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
