| 1 | Tue Nov 9 | at #22Auburn | L54-77 | 0-1 | .000 | - | | Neville Arena · Auburn, AL |
| 2 | Fri Nov 12 | at UAB | L71-85 | 0-2 | .000 | - | | Bartow Arena · Birmingham, AL |
| 3 | Mon Nov 15 | vs TBD | W82-57 | 1-2 | .333 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 4 | Thu Nov 18 | vsTBD | W84-59 | 2-2 | .500 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 5 | Sun Nov 21 | at Mississippi St | L46-66 | 2-3 | .400 | - | | Humphrey Coliseum · Starkville, MS |
| 6 | Fri Nov 26 | at Arkansas St | W75-51 | 3-3 | .500 | - | | First National Bank Arena · Jonesboro, AR |
| 7 | Sat Nov 27 | vs Kansas City | W70-62 | 4-3 | .571 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 8 | Wed Dec 1 | vs Georgia So | W59-51 | 5-3 | .625 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 9 | Mon Dec 6 | vs Presbyterian | W71-66 | 6-3 | .667 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 10 | Sat Dec 11 | at ETSU | L75-82 | 6-4 | .600 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 11 | Wed Dec 15 | at #22Xavier | L63-86 | 6-5 | .545 | - | FS1 | Cintas Center · Cincinnati, OH |
| 12 | Sat Dec 18 | vsTBD | W87-47 | 7-5 | .583 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 13 | Tue Dec 21 | at IU Indy | W80-52 | 8-5 | .615 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 14 | Wed Dec 29 | vs E Illinois | W63-50 | 9-5 | .643 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 15 | Sat Jan 1 | vs Tennessee St | PPD | 23-11 | .676 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 16 | Sat Jan 8 | at Austin Peay | W66-55 | 10-5 | .667 | - | | Winfield Dunn Center · Clarksville, TN |
| 17 | Wed Jan 12 | vs UT Martin | W76-62 | 11-5 | .688 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 18 | Sat Jan 15 | atTennessee St | W71-64 | 12-5 | .706 | - | | Gentry Center · Nashville, TN |
| 19 | Thu Jan 20 | vs Belmont | W83-74 | 13-5 | .722 | - | ESPNEWS | Ellis T. Johnson Arena · Morehead, KY |
| 20 | Sat Jan 22 | vs SIUE | W77-74 | 14-5 | .737 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 21 | Mon Jan 24 | vsTennessee St | W67-54 | 15-5 | .750 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 22 | Thu Jan 27 | at SE Missouri St | W74-73 (OT) | 16-5 | .762 | - | ESPNU | Show Me Center · Cape Girardeau, MO |
| 23 | Sat Jan 29 | at Murray St | L66-77 | 16-6 | .727 | - | | CFSB Center · Murray, KY |
| 24 | Mon Jan 31 | at Tennessee Tech | W70-56 | 17-6 | .739 | - | | Hooper Eblen Center · Cookeville, TN |
| 25 | Thu Feb 3 | vsTennessee Tech | W75-68 | 18-6 | .750 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 26 | Sat Feb 5 | vsAustin Peay | W77-52 | 19-6 | .760 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 27 | Thu Feb 10 | atBelmont | L47-48 | 19-7 | .731 | - | | Curb Event Center Arena · Nashville, TN |
| 28 | Sat Feb 12 | vs#23Murray St | L53-57 | 19-8 | .704 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 29 | Wed Feb 16 | atUT Martin | W68-60 | 20-8 | .714 | - | | Kathleen and Tom Elam Center · Martin, TN |
| 30 | Sat Feb 19 | vsSE Missouri St | L84-92 | 20-9 | .690 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 31 | Thu Feb 24 | atE Illinois | W82-46 | 21-9 | .700 | - | | Lantz Arena · Charleston, IL |
| 32 | Sat Feb 26 | atSIUE | L70-77 | 21-10 | .677 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 33 | Thu Mar 3 | vsTennessee Tech | W73-56 | 22-10 | .688 | - | | Ellis T. Johnson Arena · Morehead, KY |
| 34 | Fri Mar 4 | atBelmont | W53-51 | 23-10 | .697 | - | ESPNU | Curb Event Center Arena · Nashville, TN |
| 35 | Sat Mar 5 | atMurray St | L67-71 | 23-11 | .676 | - | ESPN2 | CFSB Center · Murray, KY |
