| 1 | Mon Nov 4 | vs W Georgia | W95-60 | 1-0 | 1.000 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 2 | Fri Nov 8 | vs Georgia St | W101-66 | 2-0 | 1.000 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 3 | Tue Nov 12 | vs SE Louisiana | W80-59 | 3-0 | 1.000 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 4 | Sun Nov 17 | vs Utah | W78-73 | 4-0 | 1.000 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 5 | Fri Nov 22 | at SMU | W84-79 | 5-0 | 1.000 | - | ESPN+ | Moody Coliseum · Dallas, TX |
| 6 | Thu Nov 28 | at UNLV | W80-58 | 6-0 | 1.000 | #25 | CBS | Thomas & Mack Center · Las Vegas, NV |
| 7 | Fri Nov 29 | vs Butler | L77-87 | 6-1 | .857 | #25 | | Humphrey Coliseum · Starkville, MS |
| 8 | Wed Dec 4 | vs #18Pitt | W90-57 | 7-1 | .875 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 9 | Sun Dec 8 | vs Prairie View | W91-84 | 8-1 | .889 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 10 | Sat Dec 14 | vs McNeese | W66-63 | 9-1 | .900 | #25 | ESPNU | Humphrey Coliseum · Starkville, MS |
| 11 | Tue Dec 17 | vs C Michigan | W83-59 | 10-1 | .909 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 12 | Sat Dec 21 | at #21Memphis | W79-66 | 11-1 | .917 | - | CBS | FedExForum · Memphis, TN |
| 13 | Mon Dec 30 | vs Bethune | W87-73 | 12-1 | .923 | #17 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 14 | Sat Jan 4 | vs South Carolina | W85-50 | 13-1 | .929 | #17 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 15 | Tue Jan 7 | at Vanderbilt | W76-64 | 14-1 | .933 | #14 | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Sat Jan 11 | vs #6Kentucky | L90-95 | 14-2 | .875 | #14 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 17 | Tue Jan 14 | at #1Auburn | L66-88 | 14-3 | .824 | #15 | SEC Network | Neville Arena · Auburn, AL |
| 18 | Sat Jan 18 | vs #21Ole Miss | W84-81 (OT) | 15-3 | .833 | #15 | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 19 | Tue Jan 21 | at #6Tennessee | L56-68 | 15-4 | .789 | #14 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 20 | Sat Jan 25 | atSouth Carolina | W65-60 (OT) | 16-4 | .800 | #14 | SEC Network | Colonial Life Arena · Columbia, SC |
| 21 | Wed Jan 29 | vs #4Alabama | L84-88 | 16-5 | .762 | #14 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 22 | Sat Feb 1 | vs #20Missouri | L61-88 | 16-6 | .727 | #14 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 23 | Sat Feb 8 | at Georgia | W76-75 | 17-6 | .739 | #22 | SEC Network | Stegeman Coliseum · Athens, GA |
| 24 | Tue Feb 11 | vs #3Florida | L68-81 | 17-7 | .708 | #22 | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 25 | Sat Feb 15 | at#19Ole Miss | W81-71 | 18-7 | .720 | #22 | ESPN2 | SJB Pavilion · Oxford, MS |
| 26 | Tue Feb 18 | vs #7Texas A&M | W70-54 | 19-7 | .731 | #21 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 27 | Sat Feb 22 | at Oklahoma | L87-93 | 19-8 | .704 | #21 | SEC Network | Lloyd Noble Center · Norman, OK |
| 28 | Tue Feb 25 | at#6Alabama | L73-111 | 19-9 | .679 | #24 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 29 | Sat Mar 1 | vs LSU | W81-69 | 20-9 | .690 | #24 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 30 | Tue Mar 4 | vs Texas | L82-87 (OT) | 20-10 | .667 | #25 | SEC Network | Humphrey Coliseum · Starkville, MS |
| 31 | Sat Mar 8 | at Arkansas | L92-93 | 20-11 | .645 | #25 | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 32 | Wed Mar 12 | vsLSU | W91-62 | 21-11 | .656 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 33 | Thu Mar 13 | at#21Missouri | L73-85 | 21-12 | .636 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 34 | Fri Mar 21 | vs #9Baylor | L72-75 | 21-13 | .618 | #8 | CBS | Humphrey Coliseum · Starkville, MS |
