| 1 | Mon Nov 3 | at 13Arizona | L87-93 | 0-1 | .000 | #3 | TNT | T-Mobile Arena · Las Vegas, NV |
| 2 | Thu Nov 6 | vsNorth Florida | W104-64 | 1-1 | .500 | #3 | SECN+ | O'Connell Center · Gainesville, FL |
| 3 | Tue Nov 11 | vsFlorida St | W78-76 | 2-1 | .667 | #10 | SEC Network | O'Connell Center · Gainesville, FL |
| 4 | Sun Nov 16 | vsMiami | W82-68 | 3-1 | .750 | #10 | ESPN | O'Connell Center · Gainesville, FL |
| 5 | Fri Nov 21 | vsMerrimack | W80-45 | 4-1 | .800 | #10 | SECN+ | O'Connell Center · Gainesville, FL |
| 6 | Thu Nov 27 | vsTCU | L80-84 | 4-2 | .667 | #10 | FS1 | Jenny Craig Pavilion · San Diego, CA |
| 7 | Fri Nov 28 | vsProvidence | W90-78 | 5-2 | .714 | #10 | FOX | Jenny Craig Pavilion · San Diego, CA |
| 8 | Tue Dec 2 | at4Duke | L66-67 | 5-3 | .625 | #15 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 9 | Tue Dec 9 | at5UConn | L73-77 | 5-4 | .556 | #18 | ESPN | Gampel Pavilion · Storrs, CT |
| 10 | Sat Dec 13 | vsG Washington | W80-70 | 6-4 | .600 | #18 | ESPN2 | O'Connell Center · Gainesville, FL |
| 11 | Wed Dec 17 | vsSt Francis PA | W102-61 | 7-4 | .636 | #23 | SEC Network | O'Connell Center · Gainesville, FL |
| 12 | Sun Dec 21 | vsColgate | W90-60 | 8-4 | .667 | #23 | SECN+ | O'Connell Center · Gainesville, FL |
| 13 | Mon Dec 29 | vsDartmouth | W94-72 | 9-4 | .692 | #22 | SEC Network | O'Connell Center · Gainesville, FL |
| 14 | Sat Jan 3 | atMissouri | L74-76 | 9-5 | .643 | #22 | SEC Network | Mizzou Arena · Columbia, MO |
| 15 | Tue Jan 6 | vs18Georgia | W92-77 | 10-5 | .667 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 16 | Sat Jan 10 | vs21Tennessee | W91-67 | 11-5 | .688 | - | ESPN | O'Connell Center · Gainesville, FL |
| 17 | Tue Jan 13 | atOklahoma | W96-79 | 12-5 | .706 | #19 | ESPN2 | Lloyd Noble Center · Norman, OK |
| 18 | Sat Jan 17 | at10Vanderbilt | W98-94 | 13-5 | .722 | #19 | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Tue Jan 20 | vsLSU | W79-61 | 14-5 | .737 | #16 | ESPN2 | O'Connell Center · Gainesville, FL |
| 20 | Sat Jan 24 | vsAuburn | L67-76 | 14-6 | .700 | #16 | ESPN | O'Connell Center · Gainesville, FL |
| 21 | Wed Jan 28 | atSouth Carolina | W95-48 | 15-6 | .714 | #19 | SEC Network | Colonial Life Arena · Columbia, SC |
| 22 | Sun Feb 1 | vs23Alabama | W100-77 | 16-6 | .727 | #19 | ABC | O'Connell Center · Gainesville, FL |
| 23 | Sat Feb 7 | atTexas A&M | W86-67 | 17-6 | .739 | #17 | SEC Network | Reed Arena · College Station, TX |
| 24 | Wed Feb 11 | atGeorgia | W86-66 | 18-6 | .750 | #14 | ESPN2 | Stegeman Coliseum · Athens, GA |
| 25 | Sat Feb 14 | vs25Kentucky | W92-83 | 19-6 | .760 | #14 | ABC | O'Connell Center · Gainesville, FL |
| 26 | Tue Feb 17 | vsSouth Carolina | W76-62 | 20-6 | .769 | #12 | SEC Network | O'Connell Center · Gainesville, FL |
| 27 | Sat Feb 21 | atOle Miss | W94-75 | 21-6 | .778 | #12 | ESPN | SJB Pavilion · Oxford, MS |
| 28 | Wed Feb 25 | atTexas | W84-71 | 22-6 | .786 | #7 | ESPN2 | Moody Center · Austin, TX |
| 29 | Sat Feb 28 | vs20Arkansas | W111-77 | 23-6 | .793 | #7 | ESPN | O'Connell Center · Gainesville, FL |
