| 1 | Tue Nov 4 | vs Texas | 8:45 PM | 19-16 | .543 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 2 | Sat Nov 8 | vsW Carolina | TBD | 8-22 | .267 | #6 | The CW Network | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Nov 11 | atArmy | TBD | 17-16 | .515 | #6 | CBS | Christl Arena · West Point, NY |
| 4 | Fri Nov 14 | vsIndiana St | 7:00 PM | 14-18 | .438 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Tue Nov 18 | vs#19Kansas | 9:00 PM | 21-13 | .618 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 6 | Fri Nov 21 | vsNiagara | 7:00 PM | 11-20 | .355 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 7 | Sun Nov 23 | vsHoward | 4:00 PM | 12-20 | .375 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 8 | Thu Nov 27 | at#14Arkansas | 8:00 PM | 22-14 | .611 | #6 | | Bud Walton Arena · Fayetteville, AR |
| 9 | Tue Dec 2 | vs#3Florida | 7:30 PM | 36-4 | .900 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 10 | Sat Dec 6 | at#22Michigan St | TBD | 30-7 | .811 | #6 | | Breslin Center · East Lansing, MI |
| 11 | Tue Dec 16 | vsLipscomb | 6:00 PM | 25-10 | .714 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 20 | vs#10Texas Tech | 8:00 PM | 28-9 | .757 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 13 | Wed Dec 31 | vsGeorgia Tech | 4:00 PM | 17-17 | .500 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 3 | atFlorida St | TBD | 17-15 | .531 | #6 | | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Tue Jan 6 | at#11Louisville | 7:00 PM | 27-8 | .771 | #6 | ESPN | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 10 | vsSMU | 2:00 PM | 24-11 | .686 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 17 | Wed Jan 14 | atCalifornia | 11:00 PM | 14-19 | .424 | #6 | ACC Network | Haas Pavilion · Berkeley, CA |
| 18 | Sat Jan 17 | atStanford | 6:00 PM | 21-14 | .600 | #6 | ACC Network | Maples Pavilion · Stanford, CA |
| 19 | Sat Jan 24 | vsWake Forest | TBD | 21-11 | .656 | #6 | | Cameron Indoor Stadium · Durham, NC |
| 20 | Mon Jan 26 | vs#11Louisville | 7:00 PM | 27-8 | .771 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Jan 31 | atVirginia Tech | 12:00 PM | 13-19 | .406 | #6 | ESPN | Cassell Coliseum · Blacksburg, VA |
| 22 | Tue Feb 3 | vsBoston College | 7:00 PM | 12-19 | .387 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 23 | Sat Feb 7 | at#25UNC | 6:30 PM | 23-14 | .622 | #6 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 10 | atPitt | TBD | 17-15 | .531 | #6 | | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 14 | vsClemson | 12:00 PM | 27-7 | .794 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Mon Feb 16 | vsSyracuse | 7:00 PM | 14-19 | .424 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 21 | vs#7Michigan | TBD | 27-10 | .730 | #6 | | Capital One Arena · Washington, D.C. |
| 28 | Tue Feb 24 | atNotre Dame | TBD | 15-18 | .455 | #6 | | Purcell Pavilion · South Bend, IN |
| 29 | Sat Feb 28 | vsVirginia | TBD | 15-17 | .469 | #6 | | Cameron Indoor Stadium · Durham, NC |
| 30 | Mon Mar 2 | atNC State | 7:00 PM | 12-19 | .387 | #6 | ESPN | PNC Arena · Raleigh, NC |
| 31 | Sat Mar 7 | vs#25UNC | 6:30 PM | 23-14 | .622 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
