| 1 | Mon Nov 4 | vs Maine | W96-62 | 1-0 | 1.000 | #7 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 2 | Fri Nov 8 | vs Army | W100-58 | 2-0 | 1.000 | #7 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Nov 12 | at #19Kentucky | L72-77 | 2-1 | .667 | #6 | ESPN | Rupp Arena · Lexington, KY |
| 4 | Sat Nov 16 | vs Wofford | W86-35 | 3-1 | .750 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Fri Nov 22 | at #17Arizona | W69-55 | 4-1 | .800 | #12 | ESPN2 | McKale Center · Tucson, AZ |
| 6 | Tue Nov 26 | vs #1Kansas | L72-75 | 4-2 | .667 | #11 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 7 | Fri Nov 29 | vs Seattle U | W70-48 | 5-2 | .714 | #11 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 8 | Wed Dec 4 | vs #2Auburn | W84-78 | 6-2 | .750 | #9 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 9 | Sun Dec 8 | at Louisville | W76-65 | 7-2 | .778 | #9 | ACC Network | KFC Yum! Center · Louisville, KY |
| 10 | Tue Dec 10 | vs Incarnate Word | W72-46 | 8-2 | .800 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 11 | Tue Dec 17 | vs George Mason | W68-47 | 9-2 | .818 | #5 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 21 | at Georgia Tech | W82-56 | 10-2 | .833 | #5 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 13 | Tue Dec 31 | vs Virginia Tech | W88-65 | 11-2 | .846 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 4 | at SMU | W89-62 | 12-2 | .857 | #4 | The CW Network | Moody Coliseum · Dallas, TX |
| 15 | Tue Jan 7 | vs Pitt | W76-47 | 13-2 | .867 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 16 | Sat Jan 11 | vs Notre Dame | W86-78 | 14-2 | .875 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 17 | Tue Jan 14 | vs Miami | W89-54 | 15-2 | .882 | #3 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 18 | Sat Jan 18 | at Boston College | W88-63 | 16-2 | .889 | #3 | ESPN | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Sat Jan 25 | at Wake Forest | W63-56 | 17-2 | .895 | #2 | ESPN | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Mon Jan 27 | vs NC State | W74-64 | 18-2 | .900 | #2 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Feb 1 | vs UNC | W87-70 | 19-2 | .905 | #2 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 22 | Wed Feb 5 | at Syracuse | W83-54 | 20-2 | .909 | #2 | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 23 | Sat Feb 8 | at Clemson | L71-77 | 20-3 | .870 | #2 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 24 | Wed Feb 12 | vs California | W78-57 | 21-3 | .875 | #3 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 25 | Sat Feb 15 | vs Stanford | W106-70 | 22-3 | .880 | #3 | ABC | Cameron Indoor Stadium · Durham, NC |
| 26 | Mon Feb 17 | at Virginia | W80-62 | 23-3 | .885 | #3 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 27 | Sat Feb 22 | at Illinois | W110-67 | 24-3 | .889 | #3 | FOX | State Farm Center · Champaign, IL |
| 28 | Tue Feb 25 | atMiami | W97-60 | 25-3 | .893 | #2 | ESPN | Watsco Center · Coral Gables, FL |
| 29 | Sat Mar 1 | vs Florida St | W100-65 | 26-3 | .897 | #2 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 30 | Mon Mar 3 | vsWake Forest | W93-60 | 27-3 | .900 | #2 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 31 | Sat Mar 8 | atUNC | W82-69 | 28-3 | .903 | #2 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 32 | Thu Mar 13 | vsGeorgia Tech | W78-70 | 29-3 | .906 | #1 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 33 | Fri Mar 14 | vsUNC | W74-71 | 30-3 | .909 | #1 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 34 | Sat Mar 15 | vs#13Louisville | W73-62 | 31-3 | .912 | #1 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 35 | Fri Mar 21 | vs #16Mount St Mary | W93-49 | 32-3 | .914 | #1 | CBS | Cameron Indoor Stadium · Durham, NC |
| 36 | Sun Mar 23 | vs #9Baylor | W89-66 | 33-3 | .917 | #1 | CBS | Cameron Indoor Stadium · Durham, NC |
