| 4 | Fri Nov 14 | vs Indiana St | 7:00 PM | 2-1 | .667 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Tue Nov 18 | vs#25Kansas | 9:00 PM | 2-1 | .667 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 6 | Fri Nov 21 | vsNiagara | 7:00 PM | 2-1 | .667 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 7 | Sun Nov 23 | vsHoward | 4:00 PM | 1-2 | .333 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 8 | Thu Nov 27 | at#21Arkansas | 8:00 PM | 2-1 | .667 | #4 | CBS | Bud Walton Arena · Fayetteville, AR |
| 9 | Tue Dec 2 | vs#10Florida | 7:30 PM | 2-1 | .667 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 10 | Sat Dec 6 | at#17Michigan St | 12:00 PM | 2-0 | 1.000 | #4 | FOX | Breslin Center · East Lansing, MI |
| 11 | Tue Dec 16 | vsLipscomb | 6:00 PM | 0-3 | .000 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 20 | at#11Texas Tech | 8:00 PM | 2-1 | .667 | #4 | ESPN | United Supermarkets Arena · Lubbock, TX |
| 13 | Wed Dec 31 | vsGeorgia Tech | 4:00 PM | 3-0 | 1.000 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 3 | atFlorida St | 3:45 PM | 2-1 | .667 | #4 | CBS | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Tue Jan 6 | at#12Louisville | 7:00 PM | 3-0 | 1.000 | #4 | ESPN | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 10 | vsSMU | 2:00 PM | 3-0 | 1.000 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 17 | Wed Jan 14 | atCalifornia | 11:00 PM | 3-0 | 1.000 | #4 | ACC Network | Haas Pavilion · Berkeley, CA |
| 18 | Sat Jan 17 | atStanford | 6:00 PM | 3-0 | 1.000 | #4 | ACC Network | Maples Pavilion · Stanford, CA |
| 19 | Sat Jan 24 | vsWake Forest | 5:45 PM | 2-1 | .667 | #4 | The CW Network | Cameron Indoor Stadium · Durham, NC |
| 20 | Mon Jan 26 | vs#12Louisville | 7:00 PM | 3-0 | 1.000 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Jan 31 | atVirginia Tech | 12:00 PM | 3-0 | 1.000 | #4 | ESPN | Cassell Coliseum · Blacksburg, VA |
| 22 | Tue Feb 3 | vsBoston College | 7:00 PM | 1-2 | .333 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 23 | Sat Feb 7 | at#18UNC | 6:30 PM | 3-0 | 1.000 | #4 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 10 | atPitt | 9:00 PM | 3-0 | 1.000 | #4 | | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 14 | vsClemson | 12:00 PM | 3-0 | 1.000 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Mon Feb 16 | vsSyracuse | 7:00 PM | 2-0 | 1.000 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 21 | vs#6Michigan | 6:30 PM | 2-0 | 1.000 | #4 | ESPN | Capital One Arena · Washington, D.C. |
| 28 | Tue Feb 24 | atNotre Dame | 7:00 PM | 3-0 | 1.000 | #4 | | Purcell Pavilion · South Bend, IN |
| 29 | Sat Feb 28 | vsVirginia | 12:00 PM | 3-0 | 1.000 | #4 | | Cameron Indoor Stadium · Durham, NC |
| 30 | Mon Mar 2 | atNC State | 7:00 PM | 3-0 | 1.000 | #4 | ESPN | PNC Arena · Raleigh, NC |
| 31 | Sat Mar 7 | vs#18UNC | 6:30 PM | 3-0 | 1.000 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
