| 1 | Tue Nov 4 | vs Texas | W75-60 | 1-0 | 1.000 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 2 | Sat Nov 8 | vsW Carolina | W95-54 | 2-0 | 1.000 | #6 | The CW Network | Cameron Indoor Stadium · Durham, NC |
| 3 | Tue Nov 11 | atArmy | W114-59 | 3-0 | 1.000 | #4 | CBSSN | Christl Arena · West Point, NY |
| 4 | Fri Nov 14 | vsIndiana St | W100-62 | 4-0 | 1.000 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 5 | Tue Nov 18 | vs24Kansas | W78-66 | 5-0 | 1.000 | #5 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 6 | Fri Nov 21 | vsNiagara | W100-42 | 6-0 | 1.000 | #5 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 7 | Sun Nov 23 | vsHoward | W93-56 | 7-0 | 1.000 | #5 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 8 | Thu Nov 27 | at22Arkansas | W80-71 | 8-0 | 1.000 | #4 | CBS | Bud Walton Arena · Fayetteville, AR |
| 9 | Tue Dec 2 | vs15Florida | W67-66 | 9-0 | 1.000 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 10 | Sat Dec 6 | at7Michigan St | W66-60 | 10-0 | 1.000 | #4 | FOX | Breslin Center · East Lansing, MI |
| 11 | Tue Dec 16 | vsLipscomb | W97-73 | 11-0 | 1.000 | #3 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 12 | Sat Dec 20 | vs19Texas Tech | L81-82 | 11-1 | .917 | #3 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 13 | Wed Dec 31 | vsGeorgia Tech | W85-79 | 12-1 | .923 | #6 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 14 | Sat Jan 3 | atFlorida St | W91-87 | 13-1 | .929 | #6 | CBS | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Tue Jan 6 | at20Louisville | W84-73 | 14-1 | .933 | #6 | ESPN | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 10 | vs24SMU | W82-75 | 15-1 | .938 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 17 | Wed Jan 14 | atCalifornia | W71-56 | 16-1 | .941 | #6 | ACC Network | Haas Pavilion · Berkeley, CA |
| 18 | Sat Jan 17 | atStanford | W80-50 | 17-1 | .944 | #6 | ACC Network | Maples Pavilion · Stanford, CA |
| 19 | Sat Jan 24 | vsWake Forest | W90-69 | 18-1 | .947 | #5 | The CW Network | Cameron Indoor Stadium · Durham, NC |
| 20 | Mon Jan 26 | vs20Louisville | W83-52 | 19-1 | .950 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Jan 31 | atVirginia Tech | W72-58 | 20-1 | .952 | #4 | ESPN | Cassell Coliseum · Blacksburg, VA |
| 22 | Tue Feb 3 | vsBoston College | W67-49 | 21-1 | .955 | #4 | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 23 | Sat Feb 7 | at14UNC | L68-71 | 21-2 | .913 | #4 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 10 | atPitt | W70-54 | 22-2 | .917 | #4 | ESPN | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 14 | vs20Clemson | W67-54 | 23-2 | .920 | #4 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Mon Feb 16 | vsSyracuse | W101-64 | 24-2 | .923 | #3 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 27 | Sat Feb 21 | vs1Michigan | W68-63 | 25-2 | .926 | #3 | ESPN | Capital One Arena · Washington, D.C. |
| 28 | Tue Feb 24 | atNotre Dame | W100-56 | 26-2 | .929 | #1 | ESPN | Purcell Pavilion · South Bend, IN |
| 29 | Sat Feb 28 | vs11Virginia | W77-51 | 27-2 | .931 | #1 | ESPN | Cameron Indoor Stadium · Durham, NC |
