| 4 | Tue Nov 18 | at #9Kentucky | 6:30 PM | 3-1 | .750 | #17 | ESPN | Rupp Arena · Lexington, KY |
| 5 | Fri Nov 21 | vsDetroit Mercy | 6:30 PM | 1-3 | .250 | #17 | BTN | Breslin Center · East Lansing, MI |
| 6 | Tue Nov 25 | atE Carolina | 1:00 PM | 2-1 | .667 | #17 | FS2 | Williams Arena at Minges Coliseum · Greenville, NC |
| 7 | Thu Nov 27 | vs#18UNC | 4:30 PM | 4-0 | 1.000 | #17 | FOX | Breslin Center · East Lansing, MI |
| 8 | Tue Dec 2 | vsIowa | 7:00 PM | 3-0 | 1.000 | #17 | Peacock | Breslin Center · East Lansing, MI |
| 9 | Sat Dec 6 | vs#4Duke | 12:00 PM | 4-0 | 1.000 | #17 | FOX | Breslin Center · East Lansing, MI |
| 10 | Sat Dec 13 | atPenn State | 12:00 PM | 4-0 | 1.000 | #17 | BTN | Bryce Jordan Center · University Park, PA |
| 11 | Tue Dec 16 | vsToledo | 6:30 PM | 2-2 | .500 | #17 | | Breslin Center · East Lansing, MI |
| 12 | Sat Dec 20 | vsOakland | 12:00 PM | 1-3 | .250 | #17 | | Breslin Center · East Lansing, MI |
| 13 | Mon Dec 29 | vsCornell | 7:00 PM | 1-2 | .333 | #17 | | Breslin Center · East Lansing, MI |
| 14 | Fri Jan 2 | atNebraska | 9:00 PM | 4-0 | 1.000 | #17 | Peacock | Pinnacle Bank Arena · Lincoln, NE |
| 15 | Mon Jan 5 | vsUSC | 8:30 PM | 3-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 16 | Thu Jan 8 | vsNorthwestern | 6:30 PM | 4-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 17 | Tue Jan 13 | vsIndiana | 8:00 PM | 3-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 18 | Sat Jan 17 | atWashington | TBD | 3-1 | .750 | #17 | | Alaska Airlines Arena · Seattle, WA |
| 19 | Tue Jan 20 | atOregon | 9:00 PM | 3-0 | 1.000 | #17 | | Matthew Knight Arena · Eugene, OR |
| 20 | Sat Jan 24 | vsMaryland | 12:00 PM | 3-1 | .750 | #17 | | Breslin Center · East Lansing, MI |
| 21 | Tue Jan 27 | atRutgers | 6:30 PM | 3-0 | 1.000 | #17 | | Jersey Mike’s Arena · Piscataway, NJ |
| 22 | Fri Jan 30 | vs#6Michigan | 8:00 PM | 3-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 23 | Wed Feb 4 | atMinnesota | 7:00 PM | 3-1 | .750 | #17 | | Williams Arena · Minneapolis, MN |
| 24 | Sat Feb 7 | vs#14Illinois | 8:00 PM | 4-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 25 | Fri Feb 13 | at#24Wisconsin | 8:00 PM | 3-0 | 1.000 | #17 | | Kohl Center · Madison, WI |
| 26 | Tue Feb 17 | vs#15UCLA | 8:30 PM | 3-1 | .750 | #17 | | Breslin Center · East Lansing, MI |
| 27 | Sun Feb 22 | vsOhio State | 1:00 PM | 3-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 28 | Thu Feb 26 | at#2Purdue | 8:00 PM | 3-0 | 1.000 | #17 | | Mackey Arena · West Lafayette, IN |
| 29 | Sun Mar 1 | atIndiana | 3:45 PM | 3-0 | 1.000 | #17 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 30 | Thu Mar 5 | vsRutgers | 8:00 PM | 3-0 | 1.000 | #17 | | Breslin Center · East Lansing, MI |
| 31 | Sun Mar 8 | at#6Michigan | 5:30 PM | 3-0 | 1.000 | #17 | | Crisler Center · Ann Arbor, MI |
