| 1 | Mon Nov 4 | vs Monmouth | W81-57 | 1-0 | 1.000 | - | B1G+ | Breslin Center · East Lansing, MI |
| 2 | Thu Nov 7 | vs Niagara | W96-60 | 2-0 | 1.000 | - | BTN | Breslin Center · East Lansing, MI |
| 3 | Tue Nov 12 | at #1Kansas | L69-77 | 2-1 | .667 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
| 4 | Sat Nov 16 | vs Bowling Green | W86-72 | 3-1 | .750 | - | BTN | Breslin Center · East Lansing, MI |
| 5 | Tue Nov 19 | vs Samford | W83-75 | 4-1 | .800 | - | Peacock | Breslin Center · East Lansing, MI |
| 6 | Mon Nov 25 | vs Colorado | W72-56 | 5-1 | .833 | - | ESPN2 | Breslin Center · East Lansing, MI |
| 7 | Tue Nov 26 | vs Memphis | L63-71 | 5-2 | .714 | - | ESPN | Breslin Center · East Lansing, MI |
| 8 | Wed Nov 27 | at #12UNC | W94-91 (OT) | 6-2 | .750 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 9 | Wed Dec 4 | at Minnesota | W90-72 | 7-2 | .778 | - | BTN | Williams Arena · Minneapolis, MN |
| 10 | Sat Dec 7 | vs Nebraska | W89-52 | 8-2 | .800 | - | BTN | Breslin Center · East Lansing, MI |
| 11 | Tue Dec 17 | at Oakland | W77-58 | 9-2 | .818 | #20 | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 12 | Sat Dec 21 | vs FAU | W86-69 | 10-2 | .833 | #20 | FS1 | Breslin Center · East Lansing, MI |
| 13 | Mon Dec 30 | vs W Michigan | W80-62 | 11-2 | .846 | #18 | BTN | Breslin Center · East Lansing, MI |
| 14 | Fri Jan 3 | at Ohio State | W69-62 | 12-2 | .857 | #18 | FOX | Value City Arena · Columbus, OH |
| 15 | Thu Jan 9 | vs Washington | W88-54 | 13-2 | .867 | #16 | BTN | Breslin Center · East Lansing, MI |
| 16 | Sun Jan 12 | at Northwestern | W78-68 | 14-2 | .875 | #16 | FOX | Welsh-Ryan Arena · Evanston, IL |
| 17 | Wed Jan 15 | vs Penn State | W90-85 | 15-2 | .882 | #12 | BTN | Breslin Center · East Lansing, MI |
| 18 | Sun Jan 19 | vs #19Illinois | W80-78 | 16-2 | .889 | #12 | CBS | Breslin Center · East Lansing, MI |
| 19 | Sat Jan 25 | at Rutgers | W81-74 | 17-2 | .895 | #8 | CBS | Jersey Mike’s Arena · Piscataway, NJ |
| 20 | Tue Jan 28 | vsMinnesota | W73-51 | 18-2 | .900 | #7 | Peacock | Breslin Center · East Lansing, MI |
| 21 | Sat Feb 1 | at USC | L64-70 | 18-3 | .857 | #7 | Peacock | Galen Center · Los Angeles, CA |
| 22 | Tue Feb 4 | at UCLA | L61-63 | 18-4 | .818 | #9 | Peacock | Pauley Pavilion · Los Angeles, CA |
| 23 | Sat Feb 8 | vs Oregon | W86-74 | 19-4 | .826 | #9 | FOX | Breslin Center · East Lansing, MI |
| 24 | Tue Feb 11 | vs Indiana | L67-71 | 19-5 | .792 | #11 | Peacock | Breslin Center · East Lansing, MI |
| 25 | Sat Feb 15 | atIllinois | W79-65 | 20-5 | .800 | #11 | FOX | State Farm Center · Champaign, IL |
| 26 | Tue Feb 18 | vs #13Purdue | W75-66 | 21-5 | .808 | #14 | Peacock | Breslin Center · East Lansing, MI |
#12Michigan
#20Maryland
#11Wisconsin
Iowa