| 1 | Mon Nov 3 | vs Mercer | 7:00 PM | 14-19 | .424 | #18 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 2 | Sat Nov 8 | vsN Kentucky | TBD | 17-16 | .515 | #18 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 3 | Wed Nov 12 | vsNorth Florida | TBD | 15-17 | .469 | #18 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 4 | Mon Nov 17 | vsRice | 8:30 PM | 13-19 | .406 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 5 | Thu Nov 20 | vsTennessee St | TBD | 17-16 | .515 | #18 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 6 | Mon Nov 24 | atRutgers | 1:00 PM | 15-17 | .469 | #18 | | Jersey Mike’s Arena · Piscataway, NJ |
| 7 | Tue Nov 25 | at#2Houston | 5:00 PM | 35-5 | .875 | #18 | | Fertitta Center · Houston, TX |
| 8 | Tue Dec 2 | atSyracuse | 7:00 PM | 14-19 | .424 | #18 | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 9 | Sat Dec 6 | at#17Illinois | 8:00 PM | 22-13 | .629 | #18 | ESPN | State Farm Center · Champaign, IL |
| 10 | Tue Dec 16 | vs#11Louisville | 7:00 PM | 27-8 | .771 | #18 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 11 | Sun Dec 21 | vsGardner-Webb | TBD | 11-20 | .355 | #18 | | Thompson-Boling Arena · Knoxville, TN |
| 12 | Tue Dec 30 | vsSC State | 8:00 PM | 20-13 | .606 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 13 | Sat Jan 3 | at#14Arkansas | 3:00 PM | 22-14 | .611 | #18 | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 14 | Tue Jan 6 | vsTexas | TBD | 19-16 | .543 | #18 | | Thompson-Boling Arena · Knoxville, TN |
| 15 | Sat Jan 10 | at#3Florida | TBD | 36-4 | .900 | #18 | | O'Connell Center · Gainesville, FL |
| 16 | Tue Jan 13 | vsTexas A&M | 7:00 PM | 23-11 | .676 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 17 | Sat Jan 17 | vs#9Kentucky | 12:00 PM | 24-12 | .667 | #18 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 24 | at#15Alabama | 8:30 PM | 28-9 | .757 | #18 | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 19 | Tue Jan 27 | atGeorgia | 7:00 PM | 20-13 | .606 | #18 | SEC Network | Stegeman Coliseum · Athens, GA |
| 20 | Sat Jan 31 | vs#20Auburn | 8:30 PM | 32-6 | .842 | #18 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 21 | Tue Feb 3 | vsOle Miss | 7:00 PM | 24-12 | .667 | #18 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 22 | Sat Feb 7 | at#9Kentucky | 8:30 PM | 24-12 | .667 | #18 | ESPN | Rupp Arena · Lexington, KY |
| 23 | Wed Feb 11 | atMississippi St | TBD | 21-13 | .618 | #18 | | Humphrey Coliseum · Starkville, MS |
| 24 | Sat Feb 14 | vsLSU | 6:00 PM | 14-18 | .438 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 25 | Tue Feb 17 | vsOklahoma | TBD | 20-14 | .588 | #18 | | Thompson-Boling Arena · Knoxville, TN |
| 26 | Sat Feb 21 | atVanderbilt | TBD | 20-13 | .606 | #18 | | Memorial Gymnasium (TN) · Nashville, TN |
| 27 | Tue Feb 24 | atMissouri | 9:00 PM | 22-12 | .647 | #18 | SEC Network | Mizzou Arena · Columbia, MO |
| 28 | Sat Feb 28 | vs#15Alabama | TBD | 28-9 | .757 | #18 | | Thompson-Boling Arena · Knoxville, TN |
| 29 | Tue Mar 3 | atSouth Carolina | 6:00 PM | 12-20 | .375 | #18 | SEC Network | Colonial Life Arena · Columbia, SC |
| 30 | Sat Mar 7 | vsVanderbilt | TBD | 20-13 | .606 | #18 | | Thompson-Boling Arena · Knoxville, TN |
