| 1 | Mon Nov 4 | vs Gardner-Webb | W80-64 | 1-0 | 1.000 | #12 | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 2 | Sat Nov 9 | at Louisville | W77-55 | 2-0 | 1.000 | #12 | ACC Network | KFC Yum! Center · Louisville, KY |
| 3 | Wed Nov 13 | vs Montana | W92-57 | 3-0 | 1.000 | #11 | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 4 | Sun Nov 17 | vs Austin Peay | W103-68 | 4-0 | 1.000 | #11 | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 5 | Thu Nov 21 | vs Virginia | W64-42 | 5-0 | 1.000 | #11 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 6 | Fri Nov 22 | at #13Baylor | W77-62 | 6-0 | 1.000 | #11 | CBS | Ferrell Center · Waco, TX |
| 7 | Wed Nov 27 | vs UT Martin | W78-35 | 7-0 | 1.000 | #7 | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 8 | Tue Dec 3 | vs Syracuse | W96-70 | 8-0 | 1.000 | #3 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 9 | Tue Dec 10 | vs Miami | W75-62 | 9-0 | 1.000 | #1 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 10 | Sat Dec 14 | at Illinois | W66-64 | 10-0 | 1.000 | #1 | FOX | State Farm Center · Champaign, IL |
| 11 | Tue Dec 17 | vs W Carolina | W84-36 | 11-0 | 1.000 | #1 | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 12 | Mon Dec 23 | vs MTSU | W82-64 | 12-0 | 1.000 | #1 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 13 | Tue Dec 31 | vs Norfolk St | W67-52 | 13-0 | 1.000 | #1 | ESPN+ | Thompson-Boling Arena · Knoxville, TN |
| 14 | Sat Jan 4 | vs #23Arkansas | W76-52 | 14-0 | 1.000 | #1 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 15 | Tue Jan 7 | at #8Florida | L43-73 | 14-1 | .933 | #1 | ESPN2 | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 16 | Sat Jan 11 | at Texas | W74-70 | 15-1 | .938 | #1 | ESPN | Moody Center · Austin, TX |
| 17 | Wed Jan 15 | vs #23Georgia | W74-56 | 16-1 | .941 | #6 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 18 | at Vanderbilt | L75-76 | 16-2 | .889 | #6 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Tue Jan 21 | vs #14Mississippi St | W68-56 | 17-2 | .895 | #6 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 20 | Sat Jan 25 | at #1Auburn | L51-53 | 17-3 | .850 | #6 | ESPN | Neville Arena · Auburn, AL |
| 21 | Tue Jan 28 | vs #12Kentucky | L73-78 | 17-4 | .810 | #8 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 22 | Sat Feb 1 | vs#5Florida | W64-44 | 18-4 | .818 | #8 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 23 | Wed Feb 5 | vs #15Missouri | W85-81 | 19-4 | .826 | #4 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 24 | Sat Feb 8 | at Oklahoma | W70-52 | 20-4 | .833 | #4 | ESPN | Lloyd Noble Center · Norman, OK |
| 25 | Tue Feb 11 | at#15Kentucky | L64-75 | 20-5 | .800 | #5 | ESPN | Rupp Arena · Lexington, KY |
| 26 | Sat Feb 15 | vsVanderbilt | W81-76 | 21-5 | .808 | #5 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
#7Texas A&M
LSU
#4Alabama
#24Ole Miss
South Carolina