| 1 | Tue Nov 9 | vs UT Martin | W90-62 | 1-0 | 1.000 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 2 | Sun Nov 14 | vsETSU | W94-62 | 2-0 | 1.000 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 3 | Sat Nov 20 | vsVillanova | L53-71 | 2-1 | .667 | - | ESPNEWS | Thompson-Boling Arena · Knoxville, TN |
| 4 | Sun Nov 21 | atUNC | W89-72 | 3-1 | .750 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Fri Nov 26 | vsTennessee Tech | W80-69 | 4-1 | .800 | #15 | | Thompson-Boling Arena · Knoxville, TN |
| 6 | Tue Nov 30 | vsPresbyterian | W86-44 | 5-1 | .833 | #13 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 7 | Sat Dec 4 | atColorado | W69-54 | 6-1 | .857 | #13 | FS1 | CU Events Center · Boulder, CO |
| 8 | Tue Dec 7 | vsTexas Tech | L52-57 (OT) | 6-2 | .750 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 9 | Sat Dec 11 | vsUNC Greensboro | W76-36 | 7-2 | .778 | #13 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 10 | Tue Dec 14 | vsSC Upstate | W96-52 | 8-2 | .800 | #18 | | Thompson-Boling Arena · Knoxville, TN |
| 12 | Wed Dec 22 | vs6Arizona | W77-73 | 9-2 | .818 | #19 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 13 | Wed Dec 29 | at19Alabama | L68-73 | 9-3 | .750 | #14 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 14 | Wed Jan 5 | vsOle Miss | W66-60 (OT) | 10-3 | .769 | #18 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 15 | Sat Jan 8 | at21LSU | L67-79 | 10-4 | .714 | #18 | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 16 | Tue Jan 11 | vsSouth Carolina | W66-46 | 11-4 | .733 | #22 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 17 | Sat Jan 15 | at18Kentucky | L79-107 | 11-5 | .688 | #22 | ESPN | Rupp Arena · Lexington, KY |
| 18 | Tue Jan 18 | atVanderbilt | W68-60 | 12-5 | .706 | #24 | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Sat Jan 22 | vs13LSU | W64-50 | 13-5 | .722 | #24 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 20 | Wed Jan 26 | vsFlorida | W78-71 | 14-5 | .737 | #18 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 21 | Sat Jan 29 | atTexas | L51-52 | 14-6 | .700 | - | ESPN | Moody Center · Austin, TX |
| 22 | Tue Feb 1 | vsTexas A&M | W90-80 | 15-6 | .714 | #22 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 23 | Sat Feb 5 | atSouth Carolina | W81-57 | 16-6 | .727 | #22 | CBS | Colonial Life Arena · Columbia, SC |
| 24 | Wed Feb 9 | atMississippi St | W72-63 | 17-6 | .739 | #19 | ESPN2 | Humphrey Coliseum · Starkville, MS |
| 25 | Sat Feb 12 | vsVanderbilt | W73-64 | 18-6 | .750 | #19 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 26 | Tue Feb 15 | vs4Kentucky | W76-63 | 19-6 | .760 | #16 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 27 | Sat Feb 19 | at23Arkansas | L48-58 | 19-7 | .731 | #16 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 28 | Tue Feb 22 | atMissouri | W80-61 | 20-7 | .741 | #17 | SEC Network | Mizzou Arena · Columbia, MO |
| 29 | Sat Feb 26 | vs3Auburn | W67-62 | 21-7 | .750 | #17 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 30 | Tue Mar 1 | atGeorgia | W75-68 | 22-7 | .759 | #13 | SEC Network | Stegeman Coliseum · Athens, GA |
| 31 | Sat Mar 5 | vsArkansas | W78-74 | 23-7 | .767 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 32 | Fri Mar 11 | vsMississippi St | W72-59 | 24-7 | .774 | - | SEC Network | Benchmark International Arena · Tampa, FL |
| 33 | Sat Mar 12 | vsKentucky | W69-62 | 25-7 | .781 | - | ESPN | Benchmark International Arena · Tampa, FL |
| 34 | Sun Mar 13 | vsTexas A&M | W65-50 | 26-7 | .788 | - | ESPN | Benchmark International Arena · Tampa, FL |
| 34 | Thu Mar 17 | vs14Longwood | W88-56 | 27-7 | .794 | #3 | CBS | Thompson-Boling Arena · Knoxville, TN |
| 35 | Sat Mar 19 | vs11Michigan | L68-76 | 27-8 | .771 | #3 | CBS | Thompson-Boling Arena · Knoxville, TN |
