| 1 | Mon Nov 4 | vs MD-Eastern | W102-63 | 1-0 | 1.000 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 2 | Sun Nov 10 | vs SE Missouri St | W85-76 | 2-0 | 1.000 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 3 | Wed Nov 13 | vs California | W85-69 | 3-0 | 1.000 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 4 | Sat Nov 16 | vs Jackson St | W94-81 | 4-0 | 1.000 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Thu Nov 21 | at Nevada | W73-71 | 5-0 | 1.000 | - | ESPNU | Lawlor Events Center · Reno, NV |
| 6 | Fri Nov 22 | vs Seton Hall | W76-60 | 6-0 | 1.000 | - | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 7 | Sun Nov 24 | vs Drake | L70-81 | 6-1 | .857 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 8 | Fri Nov 29 | vs Tennessee Tech | W87-56 | 7-1 | .875 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 9 | Wed Dec 4 | at Virginia Tech | W80-64 | 8-1 | .889 | - | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 10 | Sun Dec 8 | at TCU | W83-74 | 9-1 | .900 | - | ESPNU | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 11 | Wed Dec 18 | vs The Citadel | W105-53 | 10-1 | .909 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 12 | Sat Dec 21 | vs Austin Peay | W85-55 | 11-1 | .917 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 13 | Mon Dec 30 | vs New Orleans | W100-56 | 12-1 | .923 | - | ESPN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 14 | Sat Jan 4 | at LSU | W80-72 | 13-1 | .929 | - | ESPN2 | Pete Maravich Assembly Center · Baton Rouge, LA |
| 15 | Tue Jan 7 | vs #14Mississippi St | L64-76 | 13-2 | .867 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Sat Jan 11 | at Missouri | L66-75 | 13-3 | .813 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 17 | Wed Jan 15 | vs South Carolina | W66-63 | 14-3 | .824 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 18 | Sat Jan 18 | vs #6Tennessee | W76-75 | 15-3 | .833 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Tue Jan 21 | at #4Alabama | L87-103 | 15-4 | .789 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Sat Jan 25 | vs #9Kentucky | W74-69 | 16-4 | .800 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 21 | Sat Feb 1 | at Oklahoma | L67-97 | 16-5 | .762 | #24 | SEC Network | Lloyd Noble Center · Norman, OK |
| 22 | Tue Feb 4 | at #6Florida | L75-86 | 16-6 | .727 | - | SEC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 23 | Sat Feb 8 | vs Texas | W86-78 | 17-6 | .739 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 24 | Tue Feb 11 | vs #1Auburn | L68-80 | 17-7 | .708 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 15 | at#5Tennessee | L76-81 | 17-8 | .680 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 26 | Wed Feb 19 | at#17Kentucky | L61-82 | 17-9 | .654 | - | SEC Network | Rupp Arena · Lexington, KY |
#24Ole Miss
#7Texas A&M
Arkansas
Georgia