| 1 | Fri Nov 27 | vs Valparaiso | W77-71 | 1-0 | 1.000 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Sun Dec 13 | vsMiss Valley St | W84-41 | 2-0 | 1.000 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 6 | Wed Dec 16 | vsRichmond | L67-78 | 2-1 | .667 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 7 | Sat Dec 19 | vsRadford | W59-50 | 3-1 | .750 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 8 | Tue Dec 22 | atDavidson | L65-85 | 3-2 | .600 | - | | John M. Belk Arena · Davidson, NC |
| 9 | Sun Dec 27 | vsAlcorn St | W87-59 | 4-2 | .667 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 10 | Wed Dec 30 | vsFlorida | L72-91 | 4-3 | .571 | - | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 11 | Tue Jan 5 | atKentucky | L74-77 | 4-4 | .500 | - | SEC Network | Rupp Arena · Lexington, KY |
| 12 | Sat Jan 9 | vsMississippi St | L81-84 | 4-5 | .444 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 13 | Tue Jan 12 | vs10Tennessee | PPD | 9-16 | .360 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 14 | Sat Jan 16 | at10Tennessee | L61-81 | 4-6 | .400 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 16 | Sat Jan 23 | vsArkansas | L71-92 | 4-7 | .364 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 17 | Wed Jan 27 | atFlorida | L71-78 | 4-8 | .333 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 18 | Sat Jan 30 | vsSouth Carolina | W93-81 | 5-8 | .385 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 20 | Sat Feb 6 | atGeorgia | L70-73 | 5-9 | .357 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 21 | Tue Feb 9 | vsAuburn | L67-73 | 5-10 | .333 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Sat Feb 13 | atMississippi St | W72-51 | 6-10 | .375 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 23 | Wed Feb 17 | vsKentucky | L78-82 | 6-11 | .353 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 24 | Sat Feb 20 | at8Alabama | L78-82 | 6-12 | .333 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 25 | Wed Feb 24 | vs25Tennessee | L58-70 | 6-13 | .316 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 26 | Sat Feb 27 | vsOle Miss | W75-70 | 7-13 | .350 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 27 | Tue Mar 2 | atLSU | L68-83 | 7-14 | .333 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 28 | Thu Mar 4 | atCincinnati | W78-64 | 8-14 | .364 | - | | Fifth Third Arena · Cincinnati, OH |
| 29 | Sat Mar 6 | atOle Miss | L46-56 | 8-15 | .348 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 30 | Wed Mar 10 | vsTexas A&M | W79-68 | 9-15 | .375 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 31 | Thu Mar 11 | atFlorida | L63-69 | 9-16 | .360 | - | SEC Network | O'Connell Center · Gainesville, FL |
