| 1 | Wed Nov 10 | vs Alabama St | W91-72 | 1-0 | 1.000 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 2 | Sun Nov 14 | vsTexas St | W79-60 | 2-0 | 1.000 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 3 | Wed Nov 17 | vsVCU | L37-48 | 2-1 | .667 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 4 | Sat Nov 20 | vsWinthrop | W77-63 | 3-1 | .750 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Wed Nov 24 | atPitt | W68-52 | 4-1 | .800 | - | | Petersen Events Center · Pittsburgh, PA |
| 6 | Mon Nov 29 | vsMiss Valley St | W75-36 | 5-1 | .833 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 7 | Sat Dec 4 | atSMU | L72-84 | 5-2 | .714 | - | | Moody Coliseum · Dallas, TX |
| 8 | Tue Dec 7 | vsTemple | L68-72 (OT) | 5-3 | .625 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 9 | Fri Dec 10 | vsLoyola Chicago | L58-69 | 5-4 | .556 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 10 | Sat Dec 18 | vsAustin Peay | W77-51 | 6-4 | .600 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 11 | Wed Dec 22 | atHawai'i | W68-54 | 7-4 | .636 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 12 | Thu Dec 23 | vsBYU | W69-67 | 8-4 | .667 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 14 | Tue Jan 4 | atArkansas | W75-74 | 9-4 | .692 | - | SEC Network | Bud Walton Arena · Fayetteville, AR |
| 15 | Sat Jan 8 | vsSouth Carolina | L70-72 | 9-5 | .643 | - | ESPNU | Memorial Gymnasium (TN) · Nashville, TN |
| 16 | Tue Jan 11 | vs18Kentucky | L66-78 | 9-6 | .600 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 17 | Sat Jan 15 | atGeorgia | W73-66 | 10-6 | .625 | - | ESPN2 | Stegeman Coliseum · Athens, GA |
| 18 | Tue Jan 18 | vs24Tennessee | L60-68 | 10-7 | .588 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 19 | Sat Jan 22 | atFlorida | L42-61 | 10-8 | .556 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 20 | Wed Jan 26 | atSouth Carolina | L61-70 | 10-9 | .526 | - | ESPNU | Colonial Life Arena · Columbia, SC |
| 21 | Sat Jan 29 | vsGeorgia | W85-77 | 11-9 | .550 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Wed Feb 2 | atKentucky | L70-77 | 11-10 | .524 | - | SEC Network | Rupp Arena · Lexington, KY |
| 23 | Sat Feb 5 | vs25LSU | W75-66 | 12-10 | .545 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 24 | Tue Feb 8 | vsMissouri | W70-62 | 13-10 | .565 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 25 | Sat Feb 12 | at19Tennessee | L64-73 | 13-11 | .542 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 26 | Wed Feb 16 | at2Auburn | L80-94 | 13-12 | .520 | - | SEC Network | Neville Arena · Auburn, AL |
| 27 | Sat Feb 19 | vsTexas A&M | W72-67 | 14-12 | .538 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 28 | Tue Feb 22 | vs24Alabama | L72-74 | 14-13 | .519 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 29 | Sat Feb 26 | atMississippi St | L69-74 | 14-14 | .500 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 30 | Tue Mar 1 | vsFlorida | L78-82 | 14-15 | .483 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
| 31 | Sat Mar 5 | atOle Miss | W63-61 | 15-15 | .500 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 32 | Wed Mar 9 | vsGeorgia | W86-51 | 16-15 | .516 | - | SEC Network | Benchmark International Arena · Tampa, FL |
| 33 | Thu Mar 10 | atAlabama | W82-76 | 17-15 | .531 | - | SEC Network | Benchmark International Arena · Tampa, FL |
| 34 | Fri Mar 11 | atKentucky | L71-77 | 17-16 | .515 | - | SEC Network | Benchmark International Arena · Tampa, FL |
| 34 | Tue Mar 15 | vsBelmont | W82-71 | 18-16 | .529 | - | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 35 | Sun Mar 20 | vsDayton | W70-68 (OT) | 19-16 | .543 | - | ESPN2 | Memorial Gymnasium (TN) · Nashville, TN |
| 36 | Tue Mar 22 | atXavier | L73-75 | 19-17 | .528 | - | ESPN | Cintas Center · Cincinnati, OH |
