| 1 | Mon Nov 4 | vs Sacred Heart | W81-70 | 1-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 2 | Fri Nov 8 | at Monmouth | W103-74 | 2-0 | 1.000 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 3 | Tue Nov 12 | vs Drexel | W69-61 | 3-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Fri Nov 15 | at Boston College | L69-72 | 3-1 | .750 | - | ESPN+ | Silvio O. Conte Forum · Chestnut Hill, MA |
| 5 | Fri Nov 22 | at Florida St | L69-78 | 3-2 | .600 | - | ESPN+ | Donald L. Tucker Center · Tallahassee, FL |
| 6 | Sat Nov 23 | vs UMass | W87-80 | 4-2 | .667 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 7 | Sat Nov 30 | at La Salle | L75-83 | 4-3 | .571 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 8 | Sat Dec 7 | vs Villanova | L65-94 | 4-4 | .500 | - | | Liacouras Center · Philadelphia, PA |
| 9 | Tue Dec 10 | vs TBD | W110-81 | 5-4 | .556 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 10 | Sun Dec 15 | at Hofstra | W60-42 | 6-4 | .600 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 11 | Wed Dec 18 | vs Davidson | W62-61 | 7-4 | .636 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 12 | Sat Dec 21 | at Rhode Island | L79-85 | 7-5 | .583 | - | CBS | Ryan Center · Kingston, RI |
| 13 | Sun Dec 29 | vs Buffalo | W91-71 | 8-5 | .615 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 14 | Fri Jan 3 | vs Wichita St | W91-85 | 9-5 | .643 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 15 | Wed Jan 8 | at E Carolina | L79-80 | 9-6 | .600 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 16 | Sat Jan 11 | at Rice | W73-70 | 10-6 | .625 | - | ESPNU | Tudor Fieldhouse · Houston, TX |
| 17 | Thu Jan 16 | vs #18Memphis | W88-81 | 11-6 | .647 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 18 | Sun Jan 19 | vs Tulane | W80-77 | 12-6 | .667 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 19 | Wed Jan 22 | at North Texas | L67-76 | 12-7 | .632 | - | ESPN+ | The Super Pit · Denton, TX |
| 20 | Sat Jan 25 | at UTSA | L79-88 | 12-8 | .600 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 21 | Wed Jan 29 | vs Charlotte | W90-89 (2OT) | 13-8 | .619 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 22 | Sat Feb 1 | vsE Carolina | W98-94 (OT) | 14-8 | .636 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 23 | Thu Feb 6 | at South Florida | L91-100 (2OT) | 14-9 | .609 | - | ESPN2 | Yuengling Center · Tampa, FL |
| 24 | Sun Feb 9 | at#17Memphis | L82-90 | 14-10 | .583 | - | ESPN2 | FedExForum · Memphis, TN |
| 25 | Wed Feb 12 | vs Tulsa | L74-80 | 14-11 | .560 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 26 | Sun Feb 16 | vs FAU | L81-83 | 14-12 | .538 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 27 | Wed Feb 19 | atCharlotte | L72-78 (OT) | 14-13 | .519 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
UAB