| 1 | Wed Nov 5 | vs Delaware St | W83-65 | 1-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 2 | Tue Nov 11 | vsLa Salle | W90-63 | 2-0 | 1.000 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 3 | Sat Nov 15 | vsBoston College | L71-76 | 2-1 | .667 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Wed Nov 19 | vsHofstra | W81-76 | 3-1 | .750 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 5 | Mon Nov 24 | atUC San Diego | L76-91 | 3-2 | .600 | - | ESPNU | University Credit Union Center · Davis, CA |
| 6 | Tue Nov 25 | atPrinceton | W79-75 | 4-2 | .667 | - | ESPNU | Jadwin Gymnasium · Princeton, NJ |
| 7 | Wed Nov 26 | vsRhode Island | L75-90 | 4-3 | .571 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 8 | Mon Dec 1 | atVillanova | L56-74 | 4-4 | .500 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 9 | Sat Dec 6 | vsSaint Joseph's | L69-70 | 4-5 | .444 | - | | Liacouras Center · Philadelphia, PA |
| 10 | Tue Dec 9 | vsTBD | W103-57 | 5-5 | .500 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 11 | Sun Dec 14 | vsSt Francis PA | W95-67 | 6-5 | .545 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 12 | Thu Dec 18 | atDavidson | W68-63 | 7-5 | .583 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 13 | Mon Dec 22 | vsPrinceton | W65-61 | 8-5 | .615 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 14 | Tue Dec 30 | atCharlotte | W76-73 | 9-5 | .643 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 15 | Sat Jan 3 | vsUTSA | W76-57 | 10-5 | .667 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 16 | Wed Jan 7 | vsE Carolina | W75-67 | 11-5 | .688 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 17 | Wed Jan 14 | atMemphis | L53-55 | 11-6 | .647 | - | ESPN+ | FedExForum · Memphis, TN |
| 18 | Sun Jan 18 | vsFAU | L73-79 | 11-7 | .611 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 19 | Wed Jan 21 | atRice | W69-65 | 12-7 | .632 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 20 | Sat Jan 24 | atUTSA | W70-64 | 13-7 | .650 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 21 | Wed Jan 28 | vsCharlotte | L76-80 (OT) | 13-8 | .619 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 22 | Sat Jan 31 | vsSouth Florida | W79-78 | 14-8 | .636 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 23 | Sat Feb 7 | atE Carolina | W81-73 | 15-8 | .652 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 24 | Wed Feb 11 | atTulane | L66-77 | 15-9 | .625 | - | ESPN+ | Devlin Fieldhouse · New Orleans, LA |
| 25 | Sun Feb 15 | vsNorth Texas | L62-65 | 15-10 | .600 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 26 | Wed Feb 18 | vsUAB | L71-76 | 15-11 | .577 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 27 | Sat Feb 21 | atWichita St | L57-69 | 15-12 | .556 | - | ESPN2 | Charles Koch Arena · Wichita, KS |
| 28 | Thu Feb 26 | atFAU | L73-77 | 15-13 | .536 | - | ESPN2 | FAU Arena · Boca Raton, FL |
| 29 | Sun Mar 1 | vsRice | L74-80 | 15-14 | .517 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
