| 1 | Wed Nov 5 | vs Delaware St | 7:00 PM | 16-14 | .533 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 2 | Tue Nov 11 | vsLa Salle | 7:00 PM | 14-19 | .424 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 3 | Sat Nov 15 | vsBoston College | 2:00 PM | 12-19 | .387 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Wed Nov 19 | vsHofstra | 7:00 PM | 15-18 | .455 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 5 | Mon Nov 24 | vsUC San Diego | 4:30 PM | 30-5 | .857 | - | | Liacouras Center · Philadelphia, PA |
| 6 | Mon Dec 1 | atVillanova | 6:30 PM | 21-15 | .583 | - | | Finneran Pavilion · Villanova, PA |
| 7 | Tue Dec 9 | vsTBD | 7:00 PM | 0-0 | .000 | - | | Liacouras Center · Philadelphia, PA |
| 8 | Sun Dec 14 | vsSt Francis PA | 12:00 PM | 16-18 | .471 | - | | Liacouras Center · Philadelphia, PA |
| 9 | Thu Dec 18 | atDavidson | 7:00 PM | 17-16 | .515 | - | | John M. Belk Arena · Davidson, NC |
| 10 | Mon Dec 22 | vsPrinceton | 7:00 PM | 19-11 | .633 | - | | Liacouras Center · Philadelphia, PA |
| 11 | Tue Dec 30 | atCharlotte | 7:00 PM | 11-22 | .333 | - | | Dale F. Halton Arena · Charlotte, NC |
| 12 | Sat Jan 3 | vsUTSA | 12:00 PM | 12-19 | .387 | - | | Liacouras Center · Philadelphia, PA |
| 13 | Wed Jan 7 | vsE Carolina | 7:00 PM | 19-14 | .576 | - | | Liacouras Center · Philadelphia, PA |
| 14 | Wed Jan 14 | atMemphis | 8:00 PM | 29-6 | .829 | - | | FedExForum · Memphis, TN |
| 15 | Sun Jan 18 | vsFAU | 12:00 PM | 18-16 | .529 | - | | Liacouras Center · Philadelphia, PA |
| 16 | Wed Jan 21 | atRice | 8:00 PM | 13-19 | .406 | - | | Tudor Fieldhouse · Houston, TX |
| 17 | Sat Jan 24 | atUTSA | 2:00 PM | 12-19 | .387 | - | | UTSA Convocation Center · San Antonio, TX |
| 18 | Wed Jan 28 | vsCharlotte | 7:00 PM | 11-22 | .333 | - | | Liacouras Center · Philadelphia, PA |
| 19 | Sat Jan 31 | vsSouth Florida | 8:00 PM | 13-19 | .406 | - | | Liacouras Center · Philadelphia, PA |
| 20 | Sat Feb 7 | atE Carolina | 12:00 PM | 19-14 | .576 | - | | Williams Arena at Minges Coliseum · Greenville, NC |
| 21 | Wed Feb 11 | atTulane | 7:30 PM | 19-15 | .559 | - | | Devlin Fieldhouse · New Orleans, LA |
| 22 | Sun Feb 15 | vsNorth Texas | 2:00 PM | 27-9 | .750 | - | | Liacouras Center · Philadelphia, PA |
| 23 | Wed Feb 18 | vsUAB | 7:00 PM | 24-13 | .649 | - | | Liacouras Center · Philadelphia, PA |
| 24 | Sat Feb 21 | atWichita St | 6:00 PM | 19-15 | .559 | - | | Charles Koch Arena · Wichita, KS |
| 25 | Thu Feb 26 | atFAU | 7:00 PM | 18-16 | .529 | - | | FAU Arena · Boca Raton, FL |
| 26 | Sun Mar 1 | vsRice | 2:00 PM | 13-19 | .406 | - | | Liacouras Center · Philadelphia, PA |
| 27 | Thu Mar 5 | vsTulane | 7:00 PM | 19-15 | .559 | - | | Liacouras Center · Philadelphia, PA |
| 28 | Sun Mar 8 | atTulsa | 3:00 PM | 13-20 | .394 | - | | Donald W. Reynolds Center · Tulsa, OK |
