| 1 | Tue Nov 5 | vs Drexel | W70-62 | 1-0 | 1.000 | - | | Liacouras Center · Philadelphia, PA |
| 2 | Sat Nov 9 | vsMorgan St | W75-57 | 2-0 | 1.000 | - | | Liacouras Center · Philadelphia, PA |
| 3 | Sat Nov 16 | atLa Salle | W70-65 | 3-0 | 1.000 | - | | Tom Gola Arena · Philadelphia, PA |
| 4 | Fri Nov 22 | atUSC | W70-61 | 4-0 | 1.000 | - | | Galen Center · Los Angeles, CA |
| 5 | Thu Nov 28 | vsMaryland | L69-76 | 4-1 | .800 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 6 | Fri Nov 29 | atTexas A&M | W65-42 | 5-1 | .833 | - | ESPNEWS | Reed Arena · College Station, TX |
| 7 | Sun Dec 1 | atDavidson | W66-53 | 6-1 | .857 | - | ESPN2 | John M. Belk Arena · Davidson, NC |
| 8 | Sat Dec 7 | vsMissouri | L54-64 | 6-2 | .750 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 9 | Tue Dec 10 | vsSaint Joseph's | W108-61 | 7-2 | .778 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 10 | Tue Dec 17 | vsMiami | L77-78 | 7-3 | .700 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 11 | Sat Dec 21 | vsRider | W78-66 | 8-3 | .727 | - | | Liacouras Center · Philadelphia, PA |
| 12 | Tue Dec 31 | atUCF | W62-58 | 9-3 | .750 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 13 | Fri Jan 3 | atTulsa | L44-70 | 9-4 | .692 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 14 | Tue Jan 7 | vsHouston | L74-78 | 9-5 | .643 | - | CBSSN | Liacouras Center · Philadelphia, PA |
| 15 | Sat Jan 11 | vsTulane | L51-65 | 9-6 | .600 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 16 | Wed Jan 15 | vs16Wichita St | W65-53 | 10-6 | .625 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 17 | Sat Jan 18 | atSMU | L52-68 | 10-7 | .588 | - | ESPNU | Moody Coliseum · Dallas, TX |
| 18 | Wed Jan 22 | vsCincinnati | L82-89 | 10-8 | .556 | - | ESPNEWS | Liacouras Center · Philadelphia, PA |
| 19 | Sat Jan 25 | atPenn | L59-66 | 10-9 | .526 | - | | The Palestra · Philadelphia, PA |
| 20 | Wed Jan 29 | atUConn | L63-78 | 10-10 | .500 | - | ESPNEWS | Gampel Pavilion · Storrs, CT |
| 21 | Sat Feb 1 | vsE Carolina | W76-64 | 11-10 | .524 | - | CBSSN | Liacouras Center · Philadelphia, PA |
| 22 | Wed Feb 5 | atMemphis | L65-79 | 11-11 | .500 | - | CBSSN | FedExForum · Memphis, TN |
| 23 | Sat Feb 8 | vsSMU | W97-90 (OT) | 12-11 | .522 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 24 | Wed Feb 12 | atTulane | W72-68 | 13-11 | .542 | - | | Devlin Fieldhouse · New Orleans, LA |
| 25 | Sun Feb 16 | vs15Villanova | L56-76 | 13-12 | .520 | - | ESPN | Liacouras Center · Philadelphia, PA |
| 26 | Thu Feb 20 | vsUConn | W93-89 (2OT) | 14-12 | .538 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 27 | Sun Feb 23 | atE Carolina | L63-67 | 14-13 | .519 | - | ESPNU | Williams Arena at Minges Coliseum · Greenville, NC |
| 28 | Thu Feb 27 | atWichita St | L69-72 | 14-14 | .500 | - | ESPN | Charles Koch Arena · Wichita, KS |
| 29 | Sun Mar 1 | vsSouth Florida | L58-64 | 14-15 | .483 | - | CBSSN | Liacouras Center · Philadelphia, PA |
| 30 | Wed Mar 4 | vsTulsa | L51-61 | 14-16 | .467 | - | | Liacouras Center · Philadelphia, PA |
| 31 | Sat Mar 7 | atCincinnati | L63-64 | 14-17 | .452 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
