| 3 | Sat Dec 19 | vs NJIT | W72-60 | 1-0 | 1.000 | - | | Liacouras Center · Philadelphia, PA |
| 4 | Tue Dec 22 | at #6Houston | L50-76 | 1-1 | .500 | - | | Fertitta Center · Houston, TX |
| 5 | Wed Dec 30 | vs SMU | L71-79 | 1-2 | .333 | - | | Liacouras Center · Philadelphia, PA |
| 7 | Mon Jan 11 | atSMU | L68-79 | 1-3 | .250 | - | | Moody Coliseum · Dallas, TX |
| 8 | Thu Jan 14 | vs UCF | W62-55 | 2-3 | .400 | - | | Liacouras Center · Philadelphia, PA |
| 9 | Sat Jan 16 | at Tulane | W65-57 | 3-3 | .500 | - | | Devlin Fieldhouse · New Orleans, LA |
| 10 | Wed Jan 20 | vs Cincinnati | PPD | 5-11 | .313 | - | | Liacouras Center · Philadelphia, PA |
| 11 | Sat Jan 23 | vs#8Houston | L51-68 | 3-4 | .429 | - | CBS | Liacouras Center · Philadelphia, PA |
| 12 | Tue Jan 26 | vs Tulsa | W76-67 | 4-4 | .500 | - | | Liacouras Center · Philadelphia, PA |
| 13 | Wed Jan 27 | at South Florida | PPD | 5-11 | .313 | - | | Yuengling Center · Tampa, FL |
| 14 | Sun Jan 31 | vsTulane | L64-81 | 4-5 | .444 | - | | Liacouras Center · Philadelphia, PA |
| 15 | Thu Feb 4 | vsCincinnati | L60-63 | 4-6 | .400 | - | ESPN2 | Liacouras Center · Philadelphia, PA |
| 16 | Sun Feb 7 | at Wichita St | L67-70 | 4-7 | .364 | - | ESPNU | Charles Koch Arena · Wichita, KS |
| 18 | Fri Feb 12 | atCincinnati | L69-71 | 4-8 | .333 | - | | Fifth Third Arena · Cincinnati, OH |
| 20 | Tue Feb 16 | atTulsa | L66-72 | 4-9 | .308 | - | ESPNU | Donald W. Reynolds Center · Tulsa, OK |
| 21 | Sun Feb 21 | vsSouth Florida | L76-83 | 4-10 | .286 | - | | Liacouras Center · Philadelphia, PA |
| 22 | Wed Feb 24 | atSouth Florida | W65-47 | 5-10 | .333 | - | ESPNU | Yuengling Center · Tampa, FL |
| 24 | Thu Mar 11 | atSouth Florida | L71-73 | 5-11 | .313 | - | ESPNU | Yuengling Center · Tampa, FL |
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