| 1 | Mon Nov 3 | vs Hofstra | W82-78 | 1-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 2 | Sat Nov 8 | vsVanderbilt | L93-105 | 1-1 | .500 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 3 | Tue Nov 11 | vsFAMU | W97-60 | 2-1 | .667 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 4 | Fri Nov 14 | atTexas A&M | W86-74 | 3-1 | .750 | - | SECN+ | Reed Arena · College Station, TX |
| 5 | Mon Nov 17 | vsOakland | W87-83 | 4-1 | .800 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 6 | Thu Nov 20 | vsPitt | W77-67 | 5-1 | .833 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 7 | Tue Nov 25 | vsQuinnipiac | W102-91 | 6-1 | .857 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 8 | Sat Nov 29 | vsVMI | W82-57 | 7-1 | .875 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 9 | Sun Dec 7 | vsTowson | W86-61 | 8-1 | .889 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 10 | Wed Dec 17 | vsMercer | W81-63 | 9-1 | .900 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 11 | Sat Dec 20 | vsFGCU | W102-80 | 10-1 | .909 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 12 | Tue Dec 23 | vsFAU | W85-80 | 11-1 | .917 | - | | Addition Financial Arena · Orlando, FL |
| 13 | Sat Jan 3 | vs17Kansas | W81-75 | 12-1 | .923 | - | Peacock | Addition Financial Arena · Orlando, FL |
| 14 | Tue Jan 6 | atOklahoma St | L76-87 | 12-2 | .857 | #25 | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sun Jan 11 | vsCincinnati | W73-72 | 13-2 | .867 | #25 | ESPN2 | Addition Financial Arena · Orlando, FL |
| 16 | Wed Jan 14 | atKansas St | W82-73 | 14-2 | .875 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 17 | Sat Jan 17 | vs1Arizona | L77-84 | 14-3 | .824 | - | ESPN | Addition Financial Arena · Orlando, FL |
| 18 | Tue Jan 20 | at9Iowa State | L57-87 | 14-4 | .778 | - | CBSSN | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Jan 24 | atColorado | W95-86 | 15-4 | .789 | - | ESPN+ | CU Events Center · Boulder, CO |
| 20 | Tue Jan 27 | vsArizona St | W79-76 | 16-4 | .800 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 21 | Sat Jan 31 | vs11Texas Tech | W88-80 | 17-4 | .810 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 22 | Wed Feb 4 | at8Houston | L55-79 | 17-5 | .773 | - | FS1 | Fertitta Center · Houston, TX |
| 23 | Sun Feb 8 | atCincinnati | L72-92 | 17-6 | .739 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
| 24 | Sat Feb 14 | vsWest Virginia | L67-74 | 17-7 | .708 | - | FS1 | Addition Financial Arena · Orlando, FL |
| 25 | Tue Feb 17 | vsTCU | W82-71 | 18-7 | .720 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 26 | Sat Feb 21 | atUtah | W73-71 | 19-7 | .731 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 27 | Tue Feb 24 | at19BYU | W97-84 | 20-7 | .741 | - | ESPN2 | Marriott Center · Provo, UT |
| 28 | Sat Feb 28 | vsBaylor | L86-87 | 20-8 | .714 | - | FS1 | Addition Financial Arena · Orlando, FL |
