| 1 | Mon Nov 4 | vs #13Texas A&M | W64-61 | 1-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 2 | Fri Nov 8 | vs Purdue FW | W75-68 | 2-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 3 | Tue Nov 12 | vs FAU | W100-94 | 3-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 4 | Tue Nov 19 | vs Tennessee Tech | W80-69 | 4-0 | 1.000 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 5 | Fri Nov 22 | at #19Wisconsin | L70-86 | 4-1 | .800 | - | CBS | Kohl Center · Madison, WI |
| 6 | Sun Nov 24 | vs LSU | L102-109 (3OT) | 4-2 | .667 | - | | Addition Financial Arena · Orlando, FL |
| 7 | Wed Nov 27 | vs Milwaukee | W84-76 | 5-2 | .714 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 8 | Sun Dec 1 | vs CA Baptist | W74-59 | 6-2 | .750 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 9 | Sun Dec 8 | vs Tarleton | W66-51 | 7-2 | .778 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 10 | Sat Dec 14 | vs Tulsa | W88-75 | 8-2 | .800 | - | ESPNU | Addition Financial Arena · Orlando, FL |
| 11 | Sat Dec 21 | vs Jacksonville | W86-66 | 9-2 | .818 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 12 | Tue Dec 31 | at Texas Tech | W87-83 | 10-2 | .833 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 13 | Sun Jan 5 | vs #7Kansas | L48-99 | 10-3 | .769 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 14 | Wed Jan 8 | vs Colorado | W75-74 | 11-3 | .786 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 15 | Sat Jan 11 | at Arizona | L80-88 | 11-4 | .733 | - | ESPN | McKale Center · Tucson, AZ |
| 16 | Tue Jan 14 | at Arizona St | W95-89 | 12-4 | .750 | - | ESPNU | Desert Financial Arena · Tempe, AZ |
| 17 | Sat Jan 18 | vs #10Houston | L68-69 | 12-5 | .706 | - | CBS | Addition Financial Arena · Orlando, FL |
| 18 | Tue Jan 21 | at #3Iowa State | L83-108 | 12-6 | .667 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 19 | Sat Jan 25 | vs TCU | W85-58 | 13-6 | .684 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 20 | Tue Jan 28 | at#11Kansas | L87-91 | 13-7 | .650 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 21 | Sat Feb 1 | vs BYU | L75-81 | 13-8 | .619 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 22 | Wed Feb 5 | vs Cincinnati | L83-93 | 13-9 | .591 | - | CBS | Addition Financial Arena · Orlando, FL |
| 23 | Sat Feb 8 | at Baylor | L76-91 | 13-10 | .565 | - | ESPN+ | Ferrell Center · Waco, TX |
| 24 | Tue Feb 11 | vs#10Iowa State | L65-77 | 13-11 | .542 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 25 | Sat Feb 15 | atColorado | L63-76 | 13-12 | .520 | - | ESPN+ | CU Events Center · Boulder, CO |
| 26 | Wed Feb 19 | at Oklahoma St | L95-104 | 13-13 | .500 | - | ESPNU | Gallagher-Iba Arena · Stillwater, OK |
| 27 | Sun Feb 23 | vs Utah | W76-72 | 14-13 | .519 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 28 | Wed Feb 26 | vs Kansas St | W80-76 | 15-13 | .536 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 29 | Sat Mar 1 | atTCU | L78-89 | 15-14 | .517 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 30 | Wed Mar 5 | vsOklahoma St | W83-70 | 16-14 | .533 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 31 | Sat Mar 8 | at West Virginia | L65-72 | 16-15 | .516 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 32 | Tue Mar 11 | atUtah | W87-72 | 17-15 | .531 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 33 | Wed Mar 12 | atKansas | L94-98 (OT) | 17-16 | .515 | - | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 34 | Tue Apr 1 | vs Oregon St | W76-75 | 18-16 | .529 | - | FS1 | Addition Financial Arena · Orlando, FL |
| 35 | Thu Apr 3 | atCincinnati | W88-80 | 19-16 | .543 | - | FS1 | Fifth Third Arena · Cincinnati, OH |
| 36 | Sat Apr 5 | at Villanova | W104-98 (OT) | 20-16 | .556 | - | FOX | Finneran Pavilion · Villanova, PA |
| 37 | Sun Apr 6 | vs Nebraska | L66-77 | 20-17 | .541 | - | FOX | Addition Financial Arena · Orlando, FL |
