| 1 | Tue Nov 4 | vs Mount St Mary | W70-54 | 1-0 | 1.000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 2 | Thu Nov 6 | vsCampbell | W73-65 | 2-0 | 1.000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 3 | Sun Nov 9 | vsLehigh | W69-47 | 3-0 | 1.000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 4 | Thu Nov 13 | vsPitt | W71-49 | 4-0 | 1.000 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 5 | Mon Nov 17 | vsLafayette | W81-59 | 5-0 | 1.000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 6 | Fri Nov 21 | atClemson | L67-70 | 5-1 | .833 | - | ESPNU | TD Arena · Charleston, SC |
| 7 | Sun Nov 23 | atXavier | L68-78 | 5-2 | .714 | - | ESPN | TD Arena · Charleston, SC |
| 8 | Sun Nov 30 | vsMercyhurst | W70-38 | 6-2 | .750 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 9 | Wed Dec 3 | vsCoppin St | W91-49 | 7-2 | .778 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 10 | Sat Dec 6 | vsWake Forest | L66-75 | 7-3 | .700 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 11 | Tue Dec 9 | vsLittle Rock | W90-58 | 8-3 | .727 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 12 | Sat Dec 13 | atOhio State | L88-89 (2OT) | 8-4 | .667 | - | ESPNU | Value City Arena · Columbus, OH |
| 13 | Mon Dec 22 | vsMiss Valley St | W86-51 | 9-4 | .692 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 14 | Fri Jan 2 | at3Iowa State | L59-80 | 9-5 | .643 | - | ESPN2 | James H. Hilton Coliseum · Ames, IA |
| 15 | Tue Jan 6 | vsCincinnati | W62-60 | 10-5 | .667 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 16 | Sat Jan 10 | vs22Kansas | W86-75 | 11-5 | .688 | - | FOX | WVU Coliseum · Morgantown, WV |
| 17 | Tue Jan 13 | at7Houston | L48-77 | 11-6 | .647 | - | FS1 | Fertitta Center · Houston, TX |
| 18 | Sat Jan 17 | vsColorado | W72-61 | 12-6 | .667 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 19 | Wed Jan 21 | atArizona St | W75-63 | 13-6 | .684 | - | Peacock | Desert Financial Arena · Tempe, AZ |
| 20 | Sat Jan 24 | at1Arizona | L53-88 | 13-7 | .650 | - | CBS | McKale Center · Tucson, AZ |
| 21 | Tue Jan 27 | vsKansas St | W59-54 | 14-7 | .667 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 22 | Sat Jan 31 | vsBaylor | L53-63 | 14-8 | .636 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 23 | Thu Feb 5 | atCincinnati | W59-54 | 15-8 | .652 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Sun Feb 8 | vs13Texas Tech | L63-70 | 15-9 | .625 | - | FOX | WVU Coliseum · Morgantown, WV |
| 25 | Sat Feb 14 | atUCF | W74-67 | 16-9 | .640 | - | FS1 | Addition Financial Arena · Orlando, FL |
| 26 | Wed Feb 18 | vsUtah | L56-61 | 16-10 | .615 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 27 | Sat Feb 21 | atTCU | L54-60 | 16-11 | .593 | - | Peacock | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 28 | Tue Feb 24 | atOklahoma St | L84-91 (OT) | 16-12 | .571 | - | CBSSN | Gallagher-Iba Arena · Stillwater, OK |
| 29 | Sat Feb 28 | vs19BYU | W79-71 | 17-12 | .586 | - | FOX | WVU Coliseum · Morgantown, WV |
