| 1 | Mon Nov 4 | vs Robert Morris | W87-59 | 1-0 | 1.000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 2 | Fri Nov 8 | vs UMass | W75-69 | 2-0 | 1.000 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 3 | Fri Nov 15 | at Pitt | L62-86 | 2-1 | .667 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 4 | Wed Nov 20 | vs Iona | W86-43 | 3-1 | .750 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 5 | Wed Nov 27 | vs #3Gonzaga | W86-78 (OT) | 4-1 | .800 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 6 | Thu Nov 28 | at Louisville | L70-79 (OT) | 4-2 | .667 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 7 | Fri Nov 29 | vs #24Arizona | W83-76 (OT) | 5-2 | .714 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 8 | Fri Dec 6 | vs Georgetown | W73-60 | 6-2 | .750 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 9 | Tue Dec 10 | vs NC Central | W79-45 | 7-2 | .778 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 10 | Sat Dec 14 | vs Bethune | W84-61 | 8-2 | .800 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 11 | Sun Dec 22 | vs Mercyhurst | W67-46 | 9-2 | .818 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 12 | Tue Dec 31 | at #7Kansas | W62-61 | 10-2 | .833 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 13 | Sat Jan 4 | vs Oklahoma St | W69-50 | 11-2 | .846 | - | CBS | WVU Coliseum · Morgantown, WV |
| 14 | Tue Jan 7 | vsArizona | L56-75 | 11-3 | .786 | #21 | ESPN+ | WVU Coliseum · Morgantown, WV |
| 15 | Sun Jan 12 | at Colorado | W78-70 | 12-3 | .800 | #21 | ESPN+ | CU Events Center · Boulder, CO |
| 16 | Wed Jan 15 | at #10Houston | L54-70 | 12-4 | .750 | - | ESPN+ | Fertitta Center · Houston, TX |
| 17 | Sat Jan 18 | vs #2Iowa State | W64-57 | 13-4 | .765 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 18 | Tue Jan 21 | vs Arizona St | L57-65 | 13-5 | .722 | #23 | CBS | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 25 | at Kansas St | L60-73 | 13-6 | .684 | #23 | CBS | Bramlage Coliseum · Manhattan, KS |
| 20 | Wed Jan 29 | vs#6Houston | L49-63 | 13-7 | .650 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 21 | Sun Feb 2 | at Cincinnati | W63-50 | 14-7 | .667 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 22 | Wed Feb 5 | at TCU | L60-65 | 14-8 | .636 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 23 | Sat Feb 8 | vs Utah | W72-61 | 15-8 | .652 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 24 | Tue Feb 11 | vs BYU | L69-73 | 15-9 | .625 | - | CBS | WVU Coliseum · Morgantown, WV |
| 25 | Sat Feb 15 | at Baylor | L71-74 (OT) | 15-10 | .600 | - | ESPN2 | Ferrell Center · Waco, TX |
| 26 | Wed Feb 19 | vsCincinnati | W62-59 | 16-10 | .615 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 27 | Sat Feb 22 | at #9Texas Tech | L51-73 | 16-11 | .593 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 28 | Tue Feb 25 | vsTCU | W73-55 | 17-11 | .607 | - | CBS | WVU Coliseum · Morgantown, WV |
| 29 | Sat Mar 1 | at#25BYU | L56-77 | 17-12 | .586 | - | ESPN2 | Marriott Center · Provo, UT |
| 30 | Tue Mar 4 | atUtah | W71-69 | 18-12 | .600 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 31 | Sat Mar 8 | vs UCF | W72-65 | 19-12 | .613 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 32 | Wed Mar 12 | vsColorado | L60-67 | 19-13 | .594 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
