| 1 | Tue Nov 9 | vs Oakland | W60-53 | 1-0 | 1.000 | - | | WVU Coliseum · Morgantown, WV |
| 2 | Fri Nov 12 | vsPitt | W74-59 | 2-0 | 1.000 | - | ESPNU | WVU Coliseum · Morgantown, WV |
| 3 | Thu Nov 18 | vsElon | W87-68 | 3-0 | 1.000 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 4 | Fri Nov 19 | vsMarquette | L71-82 | 3-1 | .750 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 5 | Sun Nov 21 | vsClemson | W66-59 | 4-1 | .800 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 6 | Fri Nov 26 | vsE Kentucky | W80-77 | 5-1 | .833 | - | | WVU Coliseum · Morgantown, WV |
| 7 | Tue Nov 30 | vsBellarmine | W74-55 | 6-1 | .857 | - | | WVU Coliseum · Morgantown, WV |
| 8 | Sat Dec 4 | vsRadford | W67-51 | 7-1 | .875 | - | | WVU Coliseum · Morgantown, WV |
| 9 | Wed Dec 8 | vsUConn | W56-53 | 8-1 | .889 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 10 | Sun Dec 12 | vsKent State | W63-50 | 9-1 | .900 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 11 | Sat Dec 18 | atUAB | W65-59 | 10-1 | .909 | - | CBS | Bartow Arena · Birmingham, AL |
| 12 | Wed Dec 22 | vsYoungstown St | W82-52 | 11-1 | .917 | - | | WVU Coliseum · Morgantown, WV |
| 13 | Sat Jan 1 | at#17Texas | L59-74 | 11-2 | .846 | - | ESPNU | Moody Center · Austin, TX |
| 14 | Mon Jan 3 | atTCU | PPD | 16-17 | .485 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 15 | Sat Jan 8 | vsKansas St | W71-68 | 12-2 | .857 | - | | WVU Coliseum · Morgantown, WV |
| 16 | Tue Jan 11 | vsOklahoma St | W70-60 | 13-2 | .867 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 17 | Sat Jan 15 | at#9Kansas | L59-85 | 13-3 | .813 | - | CBS | Allen Fieldhouse · Lawrence, KS |
| 18 | Tue Jan 18 | vs#5Baylor | L68-77 | 13-4 | .765 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 22 | at#18Texas Tech | L65-78 | 13-5 | .722 | - | ESPN2 | United Supermarkets Arena · Lubbock, TX |
| 20 | Wed Jan 26 | vsOklahoma | L62-72 | 13-6 | .684 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 21 | Sat Jan 29 | atArkansas | L68-77 | 13-7 | .650 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 22 | Mon Jan 31 | at#8Baylor | L77-81 | 13-8 | .619 | - | ESPN | Ferrell Center · Waco, TX |
| 23 | Sat Feb 5 | vs#14Texas Tech | L53-60 | 13-9 | .591 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 24 | Tue Feb 8 | vsIowa State | W79-63 | 14-9 | .609 | - | | WVU Coliseum · Morgantown, WV |
| 25 | Sat Feb 12 | atOklahoma St | L58-81 | 14-10 | .583 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 26 | Mon Feb 14 | atKansas St | L73-78 | 14-11 | .560 | - | ESPN2 | Bramlage Coliseum · Manhattan, KS |
| 27 | Sat Feb 19 | vs#6Kansas | L58-71 | 14-12 | .538 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 28 | Mon Feb 21 | atTCU | L67-77 | 14-13 | .519 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 29 | Wed Feb 23 | atIowa State | L81-84 | 14-14 | .500 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 30 | Sat Feb 26 | vs#20Texas | L81-82 | 14-15 | .483 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 31 | Tue Mar 1 | atOklahoma | L59-72 | 14-16 | .467 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 32 | Sat Mar 5 | vsTCU | W70-64 | 15-16 | .484 | - | | WVU Coliseum · Morgantown, WV |
| 33 | Wed Mar 9 | atKansas St | W73-67 | 16-16 | .500 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 34 | Thu Mar 10 | atKansas | L63-87 | 16-17 | .485 | - | ESPN | Allen Fieldhouse · Lawrence, KS |
