| 1 | Fri Nov 8 | vs Akron | W94-84 | 1-0 | 1.000 | - | | WVU Coliseum · Morgantown, WV |
| 2 | Fri Nov 15 | atPitt | W68-53 | 2-0 | 1.000 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 3 | Mon Nov 18 | vsN Colorado | W69-61 | 3-0 | 1.000 | - | | WVU Coliseum · Morgantown, WV |
| 4 | Fri Nov 22 | vsBoston Univ | W69-44 | 4-0 | 1.000 | - | | WVU Coliseum · Morgantown, WV |
| 5 | Tue Nov 26 | vsNorthern Iowa | W60-55 | 5-0 | 1.000 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 6 | Wed Nov 27 | vsWichita St | W75-63 | 6-0 | 1.000 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 7 | Sun Dec 1 | vsRhode Island | W86-81 | 7-0 | 1.000 | - | | WVU Coliseum · Morgantown, WV |
| 8 | Sat Dec 7 | atSt John's | L68-70 | 7-1 | .875 | - | FS1 | Carnesecca Arena · Queens, NY |
| 9 | Thu Dec 12 | vsAustin Peay | W84-53 | 8-1 | .889 | - | | WVU Coliseum · Morgantown, WV |
| 10 | Sat Dec 14 | vsNicholls | W83-57 | 9-1 | .900 | - | | WVU Coliseum · Morgantown, WV |
| 11 | Sat Dec 21 | atYoungstown St | W75-64 | 10-1 | .909 | #25 | | Beeghly Center · Youngstown, OH |
| 12 | Sun Dec 29 | at2Ohio State | W67-59 | 11-1 | .917 | #22 | FS1 | Value City Arena · Columbus, OH |
| 13 | Sat Jan 4 | at3Kansas | L53-60 | 11-2 | .846 | #16 | | Allen Fieldhouse · Lawrence, KS |
| 14 | Mon Jan 6 | atOklahoma St | W55-41 | 12-2 | .857 | #17 | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 15 | Sat Jan 11 | vs22Texas Tech | W66-54 | 13-2 | .867 | #17 | ESPN | WVU Coliseum · Morgantown, WV |
| 16 | Tue Jan 14 | vsTCU | W81-49 | 14-2 | .875 | #12 | ESPNU | WVU Coliseum · Morgantown, WV |
| 17 | Sat Jan 18 | atKansas St | L68-84 | 14-3 | .824 | #12 | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 18 | Mon Jan 20 | vsTexas | W97-59 | 15-3 | .833 | #14 | ESPNU | WVU Coliseum · Morgantown, WV |
| 19 | Sat Jan 25 | vsMissouri | W74-51 | 16-3 | .842 | - | ESPN | WVU Coliseum · Morgantown, WV |
| 20 | Wed Jan 29 | atTexas Tech | L81-89 | 16-4 | .800 | #12 | | United Supermarkets Arena · Lubbock, TX |
| 21 | Sat Feb 1 | vsKansas St | W66-57 | 17-4 | .810 | #12 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 22 | Wed Feb 5 | vsIowa State | W76-61 | 18-4 | .818 | #13 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 23 | Sat Feb 8 | atOklahoma | L59-69 | 18-5 | .783 | #13 | ESPNU | Lloyd Noble Center · Norman, OK |
| 24 | Wed Feb 12 | vs3Kansas | L49-58 | 18-6 | .750 | #14 | | WVU Coliseum · Morgantown, WV |
| 25 | Sat Feb 15 | at1Baylor | L59-70 | 18-7 | .720 | #14 | | Ferrell Center · Waco, TX |
| 26 | Tue Feb 18 | vsOklahoma St | W65-47 | 19-7 | .731 | #17 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 27 | Sat Feb 22 | atTCU | L60-67 (OT) | 19-8 | .704 | #17 | ESPNU | Schollmaier Arena · Fort Worth, TX |
| 28 | Mon Feb 24 | atTexas | L57-67 | 19-9 | .679 | #20 | ESPNU | Moody Center · Austin, TX |
| 29 | Sat Feb 29 | vsOklahoma | L62-73 | 19-10 | .655 | #20 | ESPN2 | WVU Coliseum · Morgantown, WV |
| 30 | Tue Mar 3 | atIowa State | W77-71 | 20-10 | .667 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 31 | Sat Mar 7 | vs4Baylor | W76-64 | 21-10 | .677 | - | | WVU Coliseum · Morgantown, WV |
