| 1 | Mon Nov 3 | vs IU Indy | W118-102 | 1-0 | 1.000 | - | B1G+ | Value City Arena · Columbus, OH |
| 2 | Fri Nov 7 | vsPurdue FW | W94-68 | 2-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 3 | Tue Nov 11 | vsAppalachian St | W75-53 | 3-0 | 1.000 | - | B1G+ | Value City Arena · Columbus, OH |
| 4 | Sun Nov 16 | vsNotre Dame | W64-63 | 4-0 | 1.000 | - | FS1 | Value City Arena · Columbus, OH |
| 5 | Thu Nov 20 | vsW Michigan | W91-58 | 5-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 6 | Tue Nov 25 | vsMount St Mary | W113-60 | 6-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 7 | Fri Nov 28 | atPitt | L66-67 | 6-1 | .857 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 8 | Sat Dec 6 | atNorthwestern | W86-82 | 7-1 | .875 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 9 | Tue Dec 9 | vs13Illinois | L80-88 | 7-2 | .778 | - | Peacock | Value City Arena · Columbus, OH |
| 10 | Sat Dec 13 | vsWest Virginia | W89-88 (2OT) | 8-2 | .800 | - | ESPNU | Value City Arena · Columbus, OH |
| 11 | Sat Dec 20 | vs12UNC | L70-71 | 8-3 | .727 | - | CBS | State Farm Arena · Atlanta, GA |
| 12 | Tue Dec 23 | vsGrambling | W89-63 | 9-3 | .750 | - | BTN | Value City Arena · Columbus, OH |
| 13 | Fri Jan 2 | atRutgers | W80-73 | 10-3 | .769 | - | Peacock | Jersey Mike’s Arena · Piscataway, NJ |
| 14 | Mon Jan 5 | vs10Nebraska | L69-72 | 10-4 | .714 | - | FS1 | Value City Arena · Columbus, OH |
| 15 | Thu Jan 8 | atOregon | W72-62 | 11-4 | .733 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 16 | Sun Jan 11 | atWashington | L74-81 | 11-5 | .688 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 17 | Sat Jan 17 | vsUCLA | W86-74 | 12-5 | .706 | - | CBS | Value City Arena · Columbus, OH |
| 18 | Tue Jan 20 | vsMinnesota | W82-74 (OT) | 13-5 | .722 | - | BTN | Value City Arena · Columbus, OH |
| 19 | Fri Jan 23 | at3Michigan | L62-74 | 13-6 | .684 | - | FOX | Crisler Center · Ann Arbor, MI |
| 20 | Mon Jan 26 | vsPenn State | W84-78 | 14-6 | .700 | - | FS1 | Value City Arena · Columbus, OH |
| 21 | Sat Jan 31 | atWisconsin | L82-92 | 14-7 | .667 | - | FOX | Kohl Center · Madison, WI |
| 22 | Thu Feb 5 | atMaryland | W82-62 | 15-7 | .682 | - | FS1 | XFINITY Center · College Park, MD |
| 23 | Sun Feb 8 | vs2Michigan | L61-82 | 15-8 | .652 | - | CBS | Value City Arena · Columbus, OH |
| 24 | Wed Feb 11 | vsUSC | W89-82 | 16-8 | .667 | - | BTN | Value City Arena · Columbus, OH |
| 25 | Sat Feb 14 | vs15Virginia | L66-70 | 16-9 | .640 | - | FOX | Value City Arena · Columbus, OH |
| 26 | Tue Feb 17 | vs24Wisconsin | W86-69 | 17-9 | .654 | - | FS1 | Value City Arena · Columbus, OH |
| 27 | Sun Feb 22 | at15Michigan St | L60-66 | 17-10 | .630 | - | CBS | Breslin Center · East Lansing, MI |
| 28 | Wed Feb 25 | atIowa | L57-74 | 17-11 | .607 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 29 | Sun Mar 1 | vs8Purdue | W82-74 | 18-11 | .621 | - | CBS | Value City Arena · Columbus, OH |
