| 1 | Mon Nov 4 | vs TBD | W90-57 | 1-0 | 1.000 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 2 | Sat Nov 9 | vs Toledo | L80-90 | 1-1 | .500 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 3 | Mon Nov 11 | vs So Indiana | W77-63 | 2-1 | .667 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 4 | Sat Nov 16 | vs Bellarmine | W83-62 | 3-1 | .750 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 5 | Sat Nov 23 | at #6Purdue | L45-80 | 3-2 | .600 | - | B1G+ | Mackey Arena · West Lafayette, IN |
| 6 | Wed Nov 27 | vs SC State | W82-53 | 4-2 | .667 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 7 | Sat Nov 30 | at Western KY | L82-90 | 4-3 | .571 | - | ESPN+ | E. A. Diddle Arena · Bowling Green, KY |
| 8 | Wed Dec 4 | vs Morehead St | W80-77 | 5-3 | .625 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 9 | Sat Dec 7 | at UNC Wilmington | L69-78 | 5-4 | .556 | - | | Trask Coliseum · Wilmington, NC |
| 10 | Wed Dec 11 | at Wright St | L79-88 | 5-5 | .500 | - | ESPN+ | Nutter Center · Dayton, OH |
| 11 | Sat Dec 14 | vs Ohio | W79-70 | 6-5 | .545 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 12 | Mon Dec 16 | vsTBD | W93-63 | 7-5 | .583 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 13 | Sat Dec 21 | at Southern Miss | L66-68 | 7-6 | .538 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 14 | Sat Dec 28 | at Elon | L59-73 | 7-7 | .500 | - | | Schar Center · Elon, NC |
| 15 | Thu Jan 2 | vs Texas St | W77-71 | 8-7 | .533 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 16 | Sat Jan 4 | vs Troy | L57-58 | 8-8 | .500 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 17 | Thu Jan 9 | vs JMU | W80-78 | 9-8 | .529 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 18 | Sat Jan 11 | vs Georgia So | W81-69 | 10-8 | .556 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 19 | Thu Jan 16 | atJMU | L64-67 | 10-9 | .526 | - | ESPN+ | Atlantic Union Bank Center · Harrisonburg, VA |
| 20 | Sat Jan 18 | at Coast Car | W77-64 | 11-9 | .550 | - | ESPN+ | The HTC Center · Conway, SC |
| 21 | Thu Jan 23 | at Georgia St | W92-79 | 12-9 | .571 | - | ESPN+ | GSU Convocation Center · Atlanta, GA |
| 22 | Sat Jan 25 | atGeorgia So | W71-67 | 13-9 | .591 | - | ESPN+ | W.S. Hanner Fieldhouse · Statesboro, GA |
| 23 | Thu Jan 30 | vsGeorgia St | L81-85 | 13-10 | .565 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 24 | Sat Feb 1 | vsCoast Car | W67-62 | 14-10 | .583 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 25 | Wed Feb 5 | vs Arkansas St | W77-72 | 15-10 | .600 | - | ESPNU | Cam Henderson Center · Huntington, WV |
| 26 | Thu Feb 13 | at South Alabama | L82-91 (OT) | 15-11 | .577 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 27 | Sat Feb 15 | at Louisiana | L68-79 | 15-12 | .556 | - | ESPN+ | Cajundome · Lafayette, LA |
| 28 | Thu Feb 20 | at Old Dominion | W81-77 | 16-12 | .571 | - | ESPN+ | Chartway Arena · Norfolk, VA |
Appalachian St