| 1 | Mon Nov 4 | at Old Dominion | W83-82 | 1-0 | 1.000 | - | ESPN+ | Chartway Arena · Norfolk, VA |
| 2 | Fri Nov 8 | vs TBD | W87-78 | 2-0 | 1.000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 3 | Mon Nov 11 | at Notre Dame | L77-86 | 2-1 | .667 | - | ESPN+ | Purcell Pavilion · South Bend, IN |
| 4 | Thu Nov 14 | vs Bryant | L64-87 | 2-2 | .500 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 5 | Tue Nov 19 | at Vermont | L67-78 | 2-3 | .400 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 6 | Fri Nov 22 | vs Morgan St | W82-73 | 3-3 | .500 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 7 | Mon Nov 25 | vs NC A&T | W82-81 | 4-3 | .571 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 8 | Sun Dec 1 | at Penn State | L64-87 | 4-4 | .500 | - | BTN | Bryce Jordan Center · University Park, PA |
| 9 | Tue Dec 3 | vsTBD | W100-65 | 5-4 | .556 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 10 | Sat Dec 7 | at St Bonaventure | L55-65 | 5-5 | .500 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 11 | Thu Dec 19 | at Georgia | L49-100 | 5-6 | .455 | - | ESPN+ | Stegeman Coliseum · Athens, GA |
| 12 | Sun Dec 29 | at Temple | L71-91 | 5-7 | .417 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 13 | Sat Jan 4 | at Miami OH | L79-93 | 5-8 | .385 | - | ESPN+ | Millett Hall · Oxford, OH |
| 14 | Tue Jan 7 | vs Ohio | L79-88 | 5-9 | .357 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 15 | Fri Jan 10 | vs Kent State | L49-68 | 5-10 | .333 | - | CBS | Alumni Arena · Buffalo, NY |
| 16 | Tue Jan 14 | at Bowling Green | L61-79 | 5-11 | .313 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 17 | Sat Jan 18 | at W Michigan | W85-76 | 6-11 | .353 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 18 | Tue Jan 21 | vs Akron | L58-90 | 6-12 | .333 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 19 | Sat Jan 25 | at E Michigan | L77-90 | 6-13 | .316 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 20 | Tue Jan 28 | vs C Michigan | W75-69 | 7-13 | .350 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 21 | Sat Feb 1 | vs Ball State | L76-89 | 7-14 | .333 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 22 | Tue Feb 4 | at Toledo | L74-87 | 7-15 | .318 | - | ESPN+ | Savage Arena · Toledo, OH |
| 23 | Sat Feb 8 | vs Georgia St | L75-80 | 7-16 | .304 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 24 | Tue Feb 11 | at N Illinois | W73-67 | 8-16 | .333 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 25 | Sat Feb 15 | vsBowling Green | L59-63 | 8-17 | .320 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 26 | Tue Feb 18 | vsW Michigan | L64-97 | 8-18 | .308 | - | ESPN+ | Alumni Arena · Buffalo, NY |
