| 1 | Mon Nov 7 | vs Colgate | W88-87 | 1-0 | 1.000 | - | | Alumni Arena · Buffalo, NY |
| 2 | Sat Nov 12 | vs JMU | L62-97 | 1-1 | .500 | - | | Alumni Arena · Buffalo, NY |
| 3 | Tue Nov 15 | at #25UConn | L64-84 | 1-2 | .333 | - | CBS | Gampel Pavilion · Storrs, CT |
| 4 | Fri Nov 18 | at Drake | L72-80 | 1-3 | .250 | - | | The Knapp Center · Des Moines, IA |
| 5 | Sat Nov 19 | at Howard | L59-63 | 1-4 | .200 | - | | Burr Gymnasium · Washington, D.C. |
| 6 | Mon Nov 21 | at George Mason | W82-74 | 2-4 | .333 | - | | EagleBank Arena · Fairfax, VA |
| 7 | Sun Nov 27 | vs Canisius | W86-66 | 3-4 | .429 | - | | Alumni Arena · Buffalo, NY |
| 8 | Sat Dec 3 | vs St Bonaventure | W83-66 | 4-4 | .500 | - | | Alumni Arena · Buffalo, NY |
| 9 | Tue Dec 6 | vs TBD | W91-53 | 5-4 | .556 | - | | Alumni Arena · Buffalo, NY |
| 10 | Sat Dec 10 | vs Tulane | L63-88 | 5-5 | .500 | - | | Alumni Arena · Buffalo, NY |
| 11 | Sun Dec 18 | at West Virginia | L78-96 | 5-6 | .455 | - | | WVU Coliseum · Morgantown, WV |
| 12 | Wed Dec 21 | vsTBD | W129-62 | 6-6 | .500 | - | | Alumni Arena · Buffalo, NY |
| 13 | Fri Dec 30 | at Michigan St | L68-89 | 6-7 | .462 | - | BTN | Breslin Center · East Lansing, MI |
| 14 | Tue Jan 3 | vs Ohio | W75-72 | 7-7 | .500 | - | | Alumni Arena · Buffalo, NY |
| 15 | Sat Jan 7 | vs N Illinois | W80-62 | 8-7 | .533 | - | | Alumni Arena · Buffalo, NY |
| 16 | Tue Jan 10 | at Miami OH | L80-91 | 8-8 | .500 | - | | Millett Hall · Oxford, OH |
| 17 | Sat Jan 14 | at C Michigan | L78-87 (OT) | 8-9 | .471 | - | | McGuirk Arena · Mount Pleasant, MI |
| 18 | Tue Jan 17 | vs Bowling Green | W100-71 | 9-9 | .500 | - | | Alumni Arena · Buffalo, NY |
| 19 | Fri Jan 20 | vs Toledo | L77-86 | 9-10 | .474 | - | CBS | Alumni Arena · Buffalo, NY |
| 20 | Tue Jan 24 | at Ball State | W91-65 | 10-10 | .500 | - | | Worthen Arena · Muncie, IN |
| 21 | Fri Jan 27 | at Kent State | L68-74 | 10-11 | .476 | - | ESPNU | M.A.C. Center · Kent, OH |
| 22 | Tue Jan 31 | vs Akron | L64-81 | 10-12 | .455 | - | | Alumni Arena · Buffalo, NY |
| 23 | Sat Feb 4 | at W Michigan | W85-76 | 11-12 | .478 | - | | University Arena (MI) · Kalamazoo, MI |
| 24 | Tue Feb 7 | vs E Michigan | W102-97 | 12-12 | .500 | - | | Alumni Arena · Buffalo, NY |
| 25 | Fri Feb 10 | vsKent State | L65-72 | 12-13 | .480 | - | ESPN2 | Alumni Arena · Buffalo, NY |
| 26 | Tue Feb 14 | atOhio | L61-85 | 12-14 | .462 | - | | Convocation Center (OH) · Athens, OH |
| 27 | Sat Feb 18 | atAkron | L66-86 | 12-15 | .444 | - | | James A. Rhodes Arena · Akron, OH |
| 28 | Tue Feb 21 | vsC Michigan | W63-35 | 13-15 | .464 | - | | Alumni Arena · Buffalo, NY |
| 29 | Sat Feb 25 | atToledo | L71-101 | 13-16 | .448 | - | | Savage Arena · Toledo, OH |
| 30 | Tue Feb 28 | atN Illinois | W85-75 | 14-16 | .467 | - | | NIU Convocation Center · Dekalb, IL |
| 31 | Fri Mar 3 | vsMiami OH | W68-63 | 15-16 | .484 | - | | Alumni Arena · Buffalo, NY |
| 32 | Thu Mar 9 | atAkron | L77-101 | 15-17 | .469 | - | | James A. Rhodes Arena · Akron, OH |
