| 2 | Fri Nov 27 | at Towson | W74-65 | 1-0 | 1.000 | - | | SECU Arena · Towson, MD |
| 3 | Sat Nov 28 | atArmy | L74-78 | 1-1 | .500 | - | | Christl Arena · West Point, NY |
| 4 | Sun Dec 6 | atBowling Green | L78-86 | 1-2 | .333 | - | | Stroh Center · Bowling Green, OH |
| 5 | Thu Dec 10 | vsMercyhurst | W81-64 | 2-2 | .500 | - | | Alumni Arena · Buffalo, NY |
| 6 | Tue Dec 15 | atMiami OH | W90-62 | 3-2 | .600 | - | | Millett Hall · Oxford, OH |
| 7 | Sat Dec 19 | atSyracuse | L96-107 (OT) | 3-3 | .500 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 9 | Sat Jan 9 | vsBall State | W86-69 | 4-3 | .571 | - | | Alumni Arena · Buffalo, NY |
| 10 | Tue Jan 12 | atW Michigan | W85-69 | 5-3 | .625 | - | | University Arena (MI) · Kalamazoo, MI |
| 11 | Fri Jan 15 | vsBowling Green | L69-76 | 5-4 | .556 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 12 | Tue Jan 19 | atKent State | L81-84 | 5-5 | .500 | - | | M.A.C. Center · Kent, OH |
| 13 | Thu Jan 21 | vsE Michigan | W92-77 | 6-5 | .545 | - | | Alumni Arena · Buffalo, NY |
| 14 | Sat Jan 23 | atN Illinois | PPD | 16-9 | .640 | - | | NIU Convocation Center · Dekalb, IL |
| 15 | Tue Jan 26 | vsC Michigan | PPD | 16-9 | .640 | - | | Alumni Arena · Buffalo, NY |
| 16 | Fri Jan 29 | vsOhio | L75-76 | 6-6 | .500 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 17 | Tue Feb 2 | atBall State | W78-58 | 7-6 | .538 | - | | Worthen Arena · Muncie, IN |
| 18 | Sat Feb 6 | vsMiami OH | W88-64 | 8-6 | .571 | - | | Alumni Arena · Buffalo, NY |
| 19 | Tue Feb 9 | vsW Michigan | PPD | 16-9 | .640 | - | | Alumni Arena · Buffalo, NY |
| 20 | Fri Feb 12 | vsW Michigan | W86-54 | 9-6 | .600 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 22 | Fri Feb 19 | vsToledo | L70-80 | 9-7 | .563 | - | ESPN2 | Alumni Arena · Buffalo, NY |
| 23 | Tue Feb 23 | atN Illinois | W102-74 | 10-7 | .588 | - | | NIU Convocation Center · Dekalb, IL |
| 24 | Thu Feb 25 | vsC Michigan | W85-73 | 11-7 | .611 | - | | Alumni Arena · Buffalo, NY |
| 25 | Sat Feb 27 | atOhio | W86-66 | 12-7 | .632 | - | | Convocation Center (OH) · Athens, OH |
| 26 | Tue Mar 2 | vsAkron | W80-78 | 13-7 | .650 | - | | Alumni Arena · Buffalo, NY |
| 27 | Fri Mar 5 | vsKent State | W81-67 | 14-7 | .667 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 28 | Thu Mar 11 | vsMiami OH | W74-63 | 15-7 | .682 | - | | Alumni Arena · Buffalo, NY |
| 29 | Fri Mar 12 | vsAkron | W81-74 (OT) | 16-7 | .696 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 30 | Sat Mar 13 | vsOhio | L69-84 | 16-8 | .667 | - | ESPN2 | Alumni Arena · Buffalo, NY |
| 28 | Fri Mar 19 | at1Colorado St | L73-75 | 16-9 | .640 | #4 | ESPN2 | The Super Pit · Denton, TX |
