| 1 | Fri Nov 8 | vs Dartmouth | L63-68 | 0-1 | .000 | - | | Alumni Arena · Buffalo, NY |
| 2 | Mon Nov 11 | vs TBD | W109-72 | 1-1 | .500 | - | | Alumni Arena · Buffalo, NY |
| 3 | Sat Nov 16 | vs Harvard | W88-76 | 2-1 | .667 | - | | Alumni Arena · Buffalo, NY |
| 4 | Thu Nov 21 | at UConn | L68-79 | 2-2 | .500 | - | ESPNU | Gampel Pavilion · Storrs, CT |
| 5 | Fri Nov 22 | vs Towson | W76-73 | 3-2 | .600 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 6 | Sun Nov 24 | vs Missouri St | W75-74 | 4-2 | .667 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 7 | Sat Nov 30 | vs William & Mary | W88-77 | 5-2 | .714 | - | | Alumni Arena · Buffalo, NY |
| 8 | Tue Dec 3 | at Vanderbilt | L76-90 | 5-3 | .625 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 9 | Sun Dec 8 | at DePaul | W74-69 | 6-3 | .667 | - | FS1 | Wintrust Arena · Chicago, IL |
| 10 | Sat Dec 14 | vs Army | L76-89 | 6-4 | .600 | - | | Alumni Arena · Buffalo, NY |
| 11 | Wed Dec 18 | vs Canisius | W82-73 | 7-4 | .636 | - | | Alumni Arena · Buffalo, NY |
| 12 | Sat Dec 21 | vs Niagara | W92-72 | 8-4 | .667 | - | | Alumni Arena · Buffalo, NY |
| 13 | Mon Dec 30 | vs St Bonaventure | W84-79 | 9-4 | .692 | - | | Alumni Arena · Buffalo, NY |
| 14 | Sat Jan 4 | vs N Illinois | L72-73 | 9-5 | .643 | - | | Alumni Arena · Buffalo, NY |
| 15 | Tue Jan 7 | at Ball State | L68-88 | 9-6 | .600 | - | | Worthen Arena · Muncie, IN |
| 16 | Fri Jan 10 | at Miami OH | W83-78 | 10-6 | .625 | - | CBS | Millett Hall · Oxford, OH |
| 17 | Tue Jan 14 | vs Ohio | W76-73 | 11-6 | .647 | - | | Alumni Arena · Buffalo, NY |
| 18 | Sat Jan 18 | at C Michigan | W86-67 | 12-6 | .667 | - | | McGuirk Arena · Mount Pleasant, MI |
| 19 | Tue Jan 21 | vs W Michigan | W90-79 | 13-6 | .684 | - | | Alumni Arena · Buffalo, NY |
| 20 | Fri Jan 24 | vs Kent State | L66-70 | 13-7 | .650 | - | CBS | Alumni Arena · Buffalo, NY |
| 21 | Tue Jan 28 | at Akron | W77-74 | 14-7 | .667 | - | | James A. Rhodes Arena · Akron, OH |
| 22 | Fri Jan 31 | vs Bowling Green | L77-78 | 14-8 | .636 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 23 | Tue Feb 4 | at E Michigan | L62-66 | 14-9 | .609 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 24 | Fri Feb 7 | vsC Michigan | W65-60 | 15-9 | .625 | - | ESPNU | Alumni Arena · Buffalo, NY |
| 25 | Fri Feb 14 | at Toledo | W83-67 | 16-9 | .640 | - | CBS | Savage Arena · Toledo, OH |
| 26 | Tue Feb 18 | vsBall State | W72-59 | 17-9 | .654 | - | | Alumni Arena · Buffalo, NY |
| 27 | Fri Feb 21 | atKent State | W104-98 (2OT) | 18-9 | .667 | - | ESPN2 | M.A.C. Center · Kent, OH |
| 28 | Tue Feb 25 | atOhio | L69-80 | 18-10 | .643 | - | | Convocation Center (OH) · Athens, OH |
| 29 | Sat Feb 29 | vsAkron | L73-86 | 18-11 | .621 | - | | Alumni Arena · Buffalo, NY |
| 30 | Tue Mar 3 | vsMiami OH | W75-69 | 19-11 | .633 | - | | Alumni Arena · Buffalo, NY |
| 31 | Fri Mar 6 | atBowling Green | W88-84 | 20-11 | .645 | - | ESPNU | Stroh Center · Bowling Green, OH |
| 32 | Mon Mar 9 | vsMiami OH | L79-85 | 20-12 | .625 | - | | Alumni Arena · Buffalo, NY |
