| 1 | Mon Nov 6 | vs Fairleigh | L86-92 | 0-1 | .000 | - | | Alumni Arena · Buffalo, NY |
| 2 | Sat Nov 11 | vsSouth Alabama | L56-70 | 0-2 | .000 | - | | Alumni Arena · Buffalo, NY |
| 3 | Wed Nov 15 | vsTBD | W89-83 | 1-2 | .333 | - | | Alumni Arena · Buffalo, NY |
| 4 | Mon Nov 20 | atHofstra | L68-102 | 1-3 | .250 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 5 | Tue Nov 21 | atLouisiana | L60-68 | 1-4 | .200 | - | | Cajundome · Lafayette, LA |
| 6 | Wed Nov 22 | atIona | L64-89 | 1-5 | .167 | - | | Hynes Athletics Center · New Rochelle, NY |
| 7 | Wed Nov 29 | at22JMU | L66-81 | 1-6 | .143 | - | | Atlantic Union Bank Center · Harrisonburg, VA |
| 8 | Sat Dec 2 | vsSt Bonaventure | L65-80 | 1-7 | .125 | - | | Alumni Arena · Buffalo, NY |
| 9 | Tue Dec 5 | atButler | L59-72 | 1-8 | .111 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 10 | Sat Dec 9 | vsWestern KY | L65-82 | 1-9 | .100 | - | | Alumni Arena · Buffalo, NY |
| 11 | Thu Dec 21 | atRichmond | L66-72 | 1-10 | .091 | - | | Robins Center · Richmond, VA |
| 12 | Fri Dec 29 | vsNiagara | L63-69 | 1-11 | .083 | - | | Alumni Arena · Buffalo, NY |
| 13 | Tue Jan 2 | atC Michigan | W76-64 | 2-11 | .154 | - | | McGuirk Arena · Mount Pleasant, MI |
| 14 | Sat Jan 6 | vsW Michigan | L77-82 | 2-12 | .143 | - | | Alumni Arena · Buffalo, NY |
| 15 | Tue Jan 9 | vsMiami OH | L65-86 | 2-13 | .133 | - | | Alumni Arena · Buffalo, NY |
| 16 | Fri Jan 12 | atAkron | L59-76 | 2-14 | .125 | - | CBSSN | James A. Rhodes Arena · Akron, OH |
| 17 | Tue Jan 16 | atToledo | L66-77 | 2-15 | .118 | - | | Savage Arena · Toledo, OH |
| 18 | Tue Jan 23 | vsBall State | L59-87 | 2-16 | .111 | - | | Alumni Arena · Buffalo, NY |
| 19 | Sat Jan 27 | atE Michigan | L65-75 | 2-17 | .105 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 20 | Tue Jan 30 | atOhio | L70-91 | 2-18 | .100 | - | | Convocation Center (OH) · Athens, OH |
| 21 | Fri Feb 2 | vsKent State | L52-83 | 2-19 | .095 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 22 | Tue Feb 6 | atBowling Green | L73-87 | 2-20 | .091 | - | | Stroh Center · Bowling Green, OH |
| 23 | Sat Feb 10 | atGeorgia So | W82-81 (OT) | 3-20 | .130 | - | | W.S. Hanner Fieldhouse · Statesboro, GA |
| 24 | Tue Feb 13 | atN Illinois | L68-72 | 3-21 | .125 | - | | NIU Convocation Center · Dekalb, IL |
| 25 | Sat Feb 17 | vsAkron | L62-73 | 3-22 | .120 | - | | Alumni Arena · Buffalo, NY |
| 26 | Tue Feb 20 | vsE Michigan | W78-69 | 4-22 | .154 | - | | Alumni Arena · Buffalo, NY |
| 27 | Sat Feb 24 | atW Michigan | L72-91 | 4-23 | .148 | - | | University Arena (MI) · Kalamazoo, MI |
| 28 | Tue Feb 27 | atKent State | L64-76 | 4-24 | .143 | - | | M.A.C. Center · Kent, OH |
| 29 | Sat Mar 2 | vsToledo | L79-85 | 4-25 | .138 | - | | Alumni Arena · Buffalo, NY |
| 30 | Tue Mar 5 | vsOhio | L66-78 | 4-26 | .133 | - | CBSSN | Alumni Arena · Buffalo, NY |
| 31 | Fri Mar 8 | vsN Illinois | L68-78 | 4-27 | .129 | - | | Alumni Arena · Buffalo, NY |
