| 1 | Mon Nov 4 | at South Alabama | W74-70 | 1-0 | 1.000 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 2 | Thu Nov 7 | vs Stony Brook | L72-73 | 1-1 | .500 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 3 | Mon Nov 11 | at #15Marquette | L62-70 | 1-2 | .333 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 4 | Wed Nov 13 | at George Mason | W70-69 | 2-2 | .500 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 5 | Wed Nov 20 | vs TBD | W86-52 | 3-2 | .600 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 6 | Mon Nov 25 | at Minnesota | L65-68 | 3-3 | .500 | - | B1G+ | Williams Arena · Minneapolis, MN |
| 7 | Sun Dec 1 | vsTBD | W115-69 | 4-3 | .571 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 8 | Thu Dec 5 | atTBD | W93-69 | 5-3 | .625 | - | | Sturrus Sports & Fitness Center |
| 9 | Sat Dec 14 | at Valparaiso | L77-93 | 5-4 | .556 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 10 | Tue Dec 17 | at Mississippi St | L59-83 | 5-5 | .500 | - | ESPN+ | Humphrey Coliseum · Starkville, MS |
| 11 | Sat Dec 21 | at Arizona | L41-94 | 5-6 | .455 | - | ESPN+ | McKale Center · Tucson, AZ |
| 12 | Mon Dec 30 | vsTBD | W85-39 | 6-6 | .500 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 13 | Sat Jan 4 | vs Ohio | L55-57 | 6-7 | .462 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 14 | Tue Jan 7 | at Akron | L71-87 | 6-8 | .429 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 15 | Fri Jan 10 | at Toledo | L67-69 | 6-9 | .400 | - | CBS | Savage Arena · Toledo, OH |
| 16 | Tue Jan 14 | vs E Michigan | W82-63 | 7-9 | .438 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 17 | Sat Jan 18 | at N Illinois | W71-66 | 8-9 | .471 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 18 | Tue Jan 21 | vs Ball State | L80-82 | 8-10 | .444 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 19 | Sat Jan 25 | vs W Michigan | W73-52 | 9-10 | .474 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 20 | Tue Jan 28 | at Buffalo | L69-75 | 9-11 | .450 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 21 | Sat Feb 1 | vs Bowling Green | W90-71 | 10-11 | .476 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 22 | Tue Feb 4 | vs Miami OH | L70-76 | 10-12 | .455 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 23 | Sat Feb 8 | vs Texas St | W85-70 | 11-12 | .478 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 24 | Tue Feb 11 | at Kent State | L83-91 | 11-13 | .458 | - | ESPN+ | M.A.C. Center · Kent, OH |
| 25 | Sat Feb 15 | vsAkron | L82-85 | 11-14 | .440 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 26 | Tue Feb 18 | atOhio | L82-84 | 11-15 | .423 | - | ESPN+ | Convocation Center (OH) · Athens, OH |
| 27 | Sat Feb 22 | atW Michigan | W86-57 | 12-15 | .444 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 28 | Tue Feb 25 | vsBuffalo | W73-69 | 13-15 | .464 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 29 | Fri Feb 28 | atE Michigan | L73-84 | 13-16 | .448 | - | CBS | Convocation Center (MI) · Ypsilanti, MI |
| 30 | Tue Mar 4 | atBall State | W69-67 | 14-16 | .467 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 31 | Fri Mar 7 | vsN Illinois | L81-83 (2OT) | 14-17 | .452 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
