| 1 | Mon Nov 4 | at Florida St | L62-74 | 0-1 | .000 | - | ESPN+ | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Fri Nov 8 | at #14Purdue | L50-72 | 0-2 | .000 | - | B1G+ | Mackey Arena · West Lafayette, IN |
| 3 | Thu Nov 14 | vs Nicholls | L59-61 | 0-3 | .000 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 4 | Tue Nov 19 | vs #18Cincinnati | L60-76 | 0-4 | .000 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 5 | Sat Nov 23 | vs TBD | W85-59 | 1-4 | .200 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 6 | Wed Nov 27 | at Charleston | L64-79 | 1-5 | .167 | - | | TD Arena · Charleston, SC |
| 7 | Sat Nov 30 | vs Bellarmine | W86-70 | 2-5 | .286 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 8 | Tue Dec 3 | at Akron | L73-86 | 2-6 | .250 | - | | James A. Rhodes Arena · Akron, OH |
| 9 | Sat Dec 7 | at IU Indy | W66-64 | 3-6 | .333 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 10 | Wed Dec 11 | vsTBD | W98-79 | 4-6 | .400 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 11 | Sun Dec 15 | vs Norfolk St | W71-62 | 5-6 | .455 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 12 | Wed Dec 18 | vs Detroit Mercy | W73-60 | 6-6 | .500 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 13 | Sat Dec 21 | vs SC State | W58-47 | 7-6 | .538 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 14 | Sun Dec 29 | at Robert Morris | L93-97 (3OT) | 7-7 | .500 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 15 | Wed Jan 1 | vs Purdue FW | W69-68 (OT) | 8-7 | .533 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 16 | Sat Jan 4 | vs Green Bay | W78-60 | 9-7 | .563 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 17 | Wed Jan 8 | at Youngstown St | L61-72 | 9-8 | .529 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 18 | Sat Jan 11 | vs Oakland | L53-68 | 9-9 | .500 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 19 | Wed Jan 15 | at Cleveland St | L58-76 | 9-10 | .474 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 20 | Sat Jan 18 | vs Wright St | L70-78 | 9-11 | .450 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 21 | Fri Jan 24 | vs Milwaukee | L59-79 | 9-12 | .429 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 22 | Thu Jan 30 | atDetroit Mercy | L57-68 | 9-13 | .409 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 23 | Sat Feb 1 | atOakland | W84-75 | 10-13 | .435 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 24 | Wed Feb 5 | vsCleveland St | W85-75 | 11-13 | .458 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 25 | Sat Feb 8 | vsRobert Morris | L76-81 | 11-14 | .440 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 26 | Fri Feb 14 | atGreen Bay | W73-60 | 12-14 | .462 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 27 | Sun Feb 16 | atMilwaukee | L70-92 | 12-15 | .444 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
