| 1 | Mon Nov 6 | at MTSU | L57-74 | 0-1 | .000 | - | | Murphy Center · Murfreesboro, TN |
| 2 | Thu Nov 9 | at Washington | L67-75 | 0-2 | .000 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 3 | Tue Nov 14 | vs TBD | W85-68 | 1-2 | .333 | - | | Truist Arena · Highland Heights, KY |
| 4 | Sun Nov 19 | at Cincinnati | L66-90 | 1-3 | .250 | - | | Fifth Third Arena · Cincinnati, OH |
| 5 | Wed Nov 22 | vs Texas A&M-CC | W88-73 | 2-3 | .400 | - | | Truist Arena · Highland Heights, KY |
| 6 | Sat Nov 25 | vs Long Island | W72-64 | 3-3 | .500 | - | | Truist Arena · Highland Heights, KY |
| 7 | Wed Nov 29 | vs Robert Morris | W77-59 | 4-3 | .571 | - | | Truist Arena · Highland Heights, KY |
| 8 | Sat Dec 2 | at IU Indy | W71-55 | 5-3 | .625 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 9 | Wed Dec 6 | at Illinois St | L59-62 | 5-4 | .556 | - | | Redbird Arena · Normal, IL |
| 10 | Sat Dec 9 | vs Akron | L76-77 | 5-5 | .500 | - | | Truist Arena · Highland Heights, KY |
| 11 | Thu Dec 14 | vsTBD | W94-59 | 6-5 | .545 | - | | Truist Arena · Highland Heights, KY |
| 12 | Sun Dec 17 | at E Kentucky | W85-75 | 7-5 | .583 | - | | McBrayer Arena · Richmond, KY |
| 13 | Thu Dec 21 | at Saint Mary's | L56-92 | 7-6 | .538 | - | | University Credit Union Pavilion · Moraga, CA |
| 14 | Fri Dec 29 | at Purdue FW | L60-73 | 7-7 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 15 | Thu Jan 4 | vs Youngstown St | W79-76 | 8-7 | .533 | - | | Truist Arena · Highland Heights, KY |
| 16 | Sun Jan 7 | at Cleveland St | L85-88 (OT) | 8-8 | .500 | - | | Wolstein Center · Cleveland, OH |
| 17 | Wed Jan 10 | at Oakland | L65-70 (OT) | 8-9 | .471 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Sat Jan 13 | at Detroit Mercy | W81-76 | 9-9 | .500 | - | | Calihan Hall · Detroit, MI |
| 19 | Thu Jan 18 | vs Milwaukee | W90-72 | 10-9 | .526 | - | | Truist Arena · Highland Heights, KY |
| 20 | Sat Jan 20 | vs Green Bay | W74-52 | 11-9 | .550 | - | | Truist Arena · Highland Heights, KY |
| 21 | Thu Jan 25 | vsPurdue FW | L58-63 | 11-10 | .524 | - | ESPNU | Truist Arena · Highland Heights, KY |
| 22 | Sun Jan 28 | atYoungstown St | L52-82 | 11-11 | .500 | - | | Beeghly Center · Youngstown, OH |
| 23 | Sun Feb 4 | vs Wright St | L78-85 | 11-12 | .478 | - | | Truist Arena · Highland Heights, KY |
| 24 | Thu Feb 8 | vsOakland | W99-89 (OT) | 12-12 | .500 | - | | Truist Arena · Highland Heights, KY |
| 25 | Sat Feb 10 | vsDetroit Mercy | W79-67 | 13-12 | .520 | - | | Truist Arena · Highland Heights, KY |
| 26 | Wed Feb 14 | atGreen Bay | W58-57 | 14-12 | .538 | - | | Resch Center · Ashwaubenon, WI |
| 27 | Sat Feb 17 | atMilwaukee | L72-73 | 14-13 | .519 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Thu Feb 22 | vsCleveland St | W75-73 | 15-13 | .536 | - | | Truist Arena · Highland Heights, KY |
| 29 | Sun Feb 25 | vsIU Indy | W80-64 | 16-13 | .552 | - | | Truist Arena · Highland Heights, KY |
| 30 | Wed Feb 28 | atRobert Morris | W70-60 | 17-13 | .567 | - | | UPMC Events Center · Moon Township, PA |
| 31 | Sat Mar 2 | atWright St | L88-94 | 17-14 | .548 | - | | Nutter Center · Dayton, OH |
| 32 | Thu Mar 7 | atWright St | W99-97 (OT) | 18-14 | .563 | - | | Nutter Center · Dayton, OH |
| 33 | Mon Mar 11 | vsMilwaukee | L75-82 | 18-15 | .545 | - | ESPN2 | Truist Arena · Highland Heights, KY |
