| 1 | Tue Nov 9 | vs TBD | W82-54 | 1-0 | 1.000 | - | | Truist Arena · Highland Heights, KY |
| 2 | Fri Nov 12 | vs UNC Greensboro | L69-70 (OT) | 1-1 | .500 | - | | Truist Arena · Highland Heights, KY |
| 3 | Thu Nov 18 | vs E Michigan | W74-73 | 2-1 | .667 | - | | Truist Arena · Highland Heights, KY |
| 4 | Mon Nov 22 | vs W Illinois | L67-69 | 2-2 | .500 | - | | Truist Arena · Highland Heights, KY |
| 5 | Fri Nov 26 | at DePaul | L68-77 | 2-3 | .400 | - | FS2 | Wintrust Arena · Chicago, IL |
| 6 | Thu Dec 2 | at Cleveland St | L58-72 | 2-4 | .333 | - | | Wolstein Center · Cleveland, OH |
| 7 | Sat Dec 4 | at Purdue FW | L57-71 | 2-5 | .286 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Wed Dec 8 | vs Canisius | W75-62 | 3-5 | .375 | - | | Truist Arena · Highland Heights, KY |
| 9 | Sun Dec 12 | vsTBD | W91-55 | 4-5 | .444 | - | | Truist Arena · Highland Heights, KY |
| 10 | Sat Dec 18 | at E Kentucky | L68-81 (OT) | 4-6 | .400 | - | | McBrayer Arena · Richmond, KY |
| 11 | Wed Dec 22 | at Indiana | L61-79 | 4-7 | .364 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 12 | Thu Dec 30 | vs Green Bay | W79-74 | 5-7 | .417 | - | | Truist Arena · Highland Heights, KY |
| 13 | Sat Jan 1 | vs Milwaukee | L55-61 | 5-8 | .385 | - | | Truist Arena · Highland Heights, KY |
| 16 | Mon Jan 10 | vs Wright St | PPD | 20-12 | .625 | - | | Truist Arena · Highland Heights, KY |
| 17 | Thu Jan 13 | at Youngstown St | W68-67 | 6-8 | .429 | - | | Beeghly Center · Youngstown, OH |
| 18 | Sat Jan 15 | at Robert Morris | L64-74 | 6-9 | .400 | - | | UPMC Events Center · Moon Township, PA |
| 19 | Thu Jan 20 | at UIC | W74-70 (OT) | 7-9 | .438 | - | | Credit Union 1 Arena · Chicago, IL |
| 20 | Sat Jan 22 | at IU Indy | W60-41 | 8-9 | .471 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Tue Jan 25 | vsWright St | W73-63 | 9-9 | .500 | - | | Truist Arena · Highland Heights, KY |
| 22 | Fri Jan 28 | vsPurdue FW | W59-49 | 10-9 | .526 | - | | Truist Arena · Highland Heights, KY |
| 23 | Sun Jan 30 | vsCleveland St | W78-72 | 11-9 | .550 | - | | Truist Arena · Highland Heights, KY |
| 24 | Thu Feb 3 | vs Oakland | PPD | 20-12 | .625 | - | | Truist Arena · Highland Heights, KY |
| 25 | Fri Feb 4 | vsOakland | W87-78 (OT) | 12-9 | .571 | - | | Truist Arena · Highland Heights, KY |
| 26 | Sat Feb 5 | vs Detroit Mercy | L68-74 | 12-10 | .545 | - | | Truist Arena · Highland Heights, KY |
| 27 | Wed Feb 9 | atMilwaukee | W75-39 | 13-10 | .565 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 28 | Fri Feb 11 | atGreen Bay | W71-62 | 14-10 | .583 | - | | Resch Center · Ashwaubenon, WI |
| 29 | Sun Feb 13 | atWright St | W75-71 | 15-10 | .600 | - | | Nutter Center · Dayton, OH |
| 30 | Fri Feb 18 | atDetroit Mercy | L52-60 | 15-11 | .577 | - | | Calihan Hall · Detroit, MI |
| 31 | Sun Feb 20 | atOakland | W71-66 | 16-11 | .593 | - | | Athletics Center O'rena · Rochester, MI |
| 32 | Thu Feb 24 | vsRobert Morris | W78-64 | 17-11 | .607 | - | | Truist Arena · Highland Heights, KY |
| 33 | Sat Feb 26 | vsYoungstown St | W75-61 | 18-11 | .621 | - | | Truist Arena · Highland Heights, KY |
| 34 | Thu Mar 3 | vsDetroit Mercy | W77-59 | 19-11 | .633 | - | | Truist Arena · Highland Heights, KY |
| 35 | Mon Mar 7 | atPurdue FW | W57-43 | 20-11 | .645 | - | ESPN2 | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 36 | Tue Mar 8 | vsWright St | L71-72 | 20-12 | .625 | - | ESPN | Truist Arena · Highland Heights, KY |
