| 1 | Tue Nov 5 | vs TBD | W105-55 | 1-0 | 1.000 | - | | Truist Arena · Highland Heights, KY |
| 2 | Fri Nov 8 | at Missouri | L56-71 | 1-1 | .500 | - | | Mizzou Arena · Columbia, MO |
| 3 | Tue Nov 12 | at Coast Car | W69-68 | 2-1 | .667 | - | | The HTC Center · Conway, SC |
| 4 | Sun Nov 17 | vs Coppin St | W82-70 | 3-1 | .750 | - | | Truist Arena · Highland Heights, KY |
| 5 | Wed Nov 20 | at Ball State | W59-57 | 4-1 | .800 | - | | Worthen Arena · Muncie, IN |
| 6 | Sat Nov 23 | vs Texas So | L96-98 (2OT) | 4-2 | .667 | - | | Truist Arena · Highland Heights, KY |
| 7 | Mon Nov 25 | vsTBD | W86-56 | 5-2 | .714 | - | | Truist Arena · Highland Heights, KY |
| 8 | Sat Nov 30 | at Arkansas | L60-66 | 5-3 | .625 | - | | Bud Walton Arena · Fayetteville, AR |
| 9 | Tue Dec 3 | at Miami OH | W76-54 | 6-3 | .667 | - | | Millett Hall · Oxford, OH |
| 10 | Sun Dec 8 | vs E Kentucky | W76-57 | 7-3 | .700 | - | | Truist Arena · Highland Heights, KY |
| 11 | Sun Dec 15 | vs Illinois St | W79-64 | 8-3 | .727 | - | | Truist Arena · Highland Heights, KY |
| 12 | Sat Dec 21 | at UNC Greensboro | L50-67 | 8-4 | .667 | - | | Greensboro Coliseum · Greensboro, NC |
| 13 | Sat Dec 28 | vs Milwaukee | W74-64 | 9-4 | .692 | - | | Truist Arena · Highland Heights, KY |
| 14 | Mon Dec 30 | vs Green Bay | L59-73 | 9-5 | .643 | - | | Truist Arena · Highland Heights, KY |
| 15 | Fri Jan 3 | at Detroit Mercy | L58-66 | 9-6 | .600 | - | | Calihan Hall · Detroit, MI |
| 16 | Sun Jan 5 | at Oakland | W75-64 | 10-6 | .625 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Fri Jan 10 | at UIC | W68-52 | 11-6 | .647 | - | ESPN2 | Credit Union 1 Arena · Chicago, IL |
| 18 | Sun Jan 12 | at IU Indy | W96-71 | 12-6 | .667 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Thu Jan 16 | vs Youngstown St | W88-63 | 13-6 | .684 | - | | Truist Arena · Highland Heights, KY |
| 20 | Sat Jan 18 | vs Cleveland St | W75-49 | 14-6 | .700 | - | | Truist Arena · Highland Heights, KY |
| 21 | Fri Jan 24 | at Wright St | L63-95 | 14-7 | .667 | - | ESPNU | Nutter Center · Dayton, OH |
| 22 | Fri Jan 31 | atGreen Bay | W71-62 | 15-7 | .682 | - | ESPNU | Resch Center · Ashwaubenon, WI |
| 23 | Sun Feb 2 | atMilwaukee | W65-56 | 16-7 | .696 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Thu Feb 6 | vsOakland | W73-70 | 17-7 | .708 | - | | Truist Arena · Highland Heights, KY |
| 25 | Sat Feb 8 | vsDetroit Mercy | W84-65 | 18-7 | .720 | - | | Truist Arena · Highland Heights, KY |
| 26 | Fri Feb 14 | vsIU Indy | W84-70 | 19-7 | .731 | - | | Truist Arena · Highland Heights, KY |
| 27 | Sun Feb 16 | vsUIC | L43-73 | 19-8 | .704 | - | | Truist Arena · Highland Heights, KY |
| 28 | Thu Feb 20 | atCleveland St | W73-59 | 20-8 | .714 | - | | Wolstein Center · Cleveland, OH |
| 29 | Sat Feb 22 | atYoungstown St | W61-59 | 21-8 | .724 | - | | Beeghly Center · Youngstown, OH |
| 30 | Fri Feb 28 | vsWright St | L62-64 | 21-9 | .700 | - | ESPNU | Truist Arena · Highland Heights, KY |
| 31 | Mon Mar 9 | vsGreen Bay | W80-69 | 22-9 | .710 | - | ESPN2 | Truist Arena · Highland Heights, KY |
| 32 | Tue Mar 10 | vsUIC | W71-62 | 23-9 | .719 | - | ESPN | Truist Arena · Highland Heights, KY |
