| 1 | Mon Nov 3 | at 21Gonzaga | L43-98 | 0-1 | .000 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 2 | Thu Nov 6 | atTexas A&M | L70-104 | 0-2 | .000 | - | SECN+ | Reed Arena · College Station, TX |
| 3 | Wed Nov 12 | vsSamford | L90-93 (OT) | 0-3 | .000 | - | | H&PE Arena · Houston, TX |
| 4 | Sat Nov 15 | atTexas St | L67-77 | 0-4 | .000 | - | ESPN+ | Strahan Arena · San Marcos, TX |
| 5 | Thu Nov 20 | atVanderbilt | L74-109 | 0-5 | .000 | - | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 6 | Wed Nov 26 | vsTBD | W102-44 | 1-5 | .167 | - | | H&PE Arena · Houston, TX |
| 7 | Sat Dec 6 | vsSam Houston | L70-82 | 1-6 | .143 | - | YouTube | H&PE Arena · Houston, TX |
| 8 | Sun Dec 14 | atMinnesota | L53-89 | 1-7 | .125 | - | BTN | Williams Arena · Minneapolis, MN |
| 9 | Wed Dec 17 | atNC State | L72-108 | 1-8 | .111 | - | ACC Extra | PNC Arena · Raleigh, NC |
| 10 | Mon Dec 22 | vsAbilene Chrstn | L68-75 | 1-9 | .100 | - | YouTube | H&PE Arena · Houston, TX |
| 11 | Tue Dec 30 | vsTBD | W80-56 | 2-9 | .182 | - | YouTube | H&PE Arena · Houston, TX |
| 12 | Sat Jan 3 | atSouthern | L73-84 | 2-10 | .167 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 13 | Mon Jan 5 | atGrambling | L67-84 | 2-11 | .154 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 14 | Sat Jan 10 | vsAR-Pine Bluff | L66-74 | 2-12 | .143 | - | | H&PE Arena · Houston, TX |
| 15 | Mon Jan 12 | vsMiss Valley St | W84-51 | 3-12 | .200 | - | | H&PE Arena · Houston, TX |
| 16 | Sat Jan 17 | atAlcorn St | W72-71 | 4-12 | .250 | - | | Davey L. Whitney Complex · Lorman, MS |
| 17 | Mon Jan 19 | atJackson St | L89-94 | 4-13 | .235 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 18 | Sat Jan 24 | vsAlabama A&M | W89-74 | 5-13 | .278 | - | | H&PE Arena · Houston, TX |
| 19 | Tue Jan 27 | vsAlabama St | W96-64 | 6-13 | .316 | - | | H&PE Arena · Houston, TX |
| 20 | Sat Jan 31 | atPrairie View | L78-85 | 6-14 | .300 | - | | William Nicks Building · Prairie View, TX |
| 21 | Sat Feb 7 | atFAMU | W62-57 | 7-14 | .333 | - | | Al Lawson Center · Tallahassee, FL |
| 22 | Mon Feb 9 | atBethune | L69-79 (OT) | 7-15 | .318 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 23 | Sat Feb 14 | vsGrambling | W82-79 | 8-15 | .348 | - | | H&PE Arena · Houston, TX |
| 24 | Mon Feb 16 | vsSouthern | W74-73 | 9-15 | .375 | - | | H&PE Arena · Houston, TX |
| 25 | Thu Feb 19 | atAR-Pine Bluff | W83-64 | 10-15 | .400 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 26 | Sat Feb 21 | atMiss Valley St | L71-72 | 10-16 | .385 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 27 | Thu Feb 26 | vsAlcorn St | W92-87 (OT) | 11-16 | .407 | - | | H&PE Arena · Houston, TX |
| 28 | Sat Feb 28 | vsJackson St | W82-57 | 12-16 | .429 | - | | H&PE Arena · Houston, TX |
