| 1 | Mon Nov 4 | at Xavier | L69-78 | 0-1 | .000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 2 | Wed Nov 6 | vs TBD | W100-66 | 1-1 | .500 | - | | H&PE Arena · Houston, TX |
| 3 | Sun Nov 10 | at Georgia | L64-92 | 1-2 | .333 | - | ESPN+ | Stegeman Coliseum · Athens, GA |
| 4 | Tue Nov 12 | at Georgia Tech | L62-81 | 1-3 | .250 | - | ESPN+ | McCamish Pavilion · Atlanta, GA |
| 5 | Sun Nov 17 | at Samford | L82-97 | 1-4 | .200 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 6 | Sun Nov 24 | at New Mexico | L68-99 | 1-5 | .167 | - | | The Pit · Albuquerque, NM |
| 7 | Wed Nov 27 | vsTBD | W80-72 | 2-5 | .286 | - | | H&PE Arena · Houston, TX |
| 8 | Sun Dec 1 | vs Texas St | L59-72 | 2-6 | .250 | - | | H&PE Arena · Houston, TX |
| 9 | Sat Dec 7 | at Sam Houston | L71-87 | 2-7 | .222 | - | ESPN+ | Bernard G. Johnson Coliseum · Huntsville, TX |
| 10 | Sat Dec 14 | at Nevada | L73-105 | 2-8 | .200 | - | | Lawlor Events Center · Reno, NV |
| 11 | Tue Dec 17 | at Boise St | L51-82 | 2-9 | .182 | - | | ExtraMile Arena · Boise, ID |
| 12 | Sat Dec 21 | at Abilene Chrstn | L65-69 | 2-10 | .167 | - | ESPN+ | Moody Coliseum (Abilene) · Abilene, TX |
| 13 | Sat Dec 28 | vsTBD | W103-68 | 3-10 | .231 | - | | H&PE Arena · Houston, TX |
| 14 | Sat Jan 4 | vs Southern | L58-67 | 3-11 | .214 | - | | H&PE Arena · Houston, TX |
| 15 | Mon Jan 6 | vs Grambling | W71-66 (OT) | 4-11 | .267 | - | ESPNU | H&PE Arena · Houston, TX |
| 16 | Mon Jan 13 | at Miss Valley St | W82-53 | 5-11 | .313 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 17 | Sat Jan 18 | vs Alcorn St | W66-57 | 6-11 | .353 | - | | H&PE Arena · Houston, TX |
| 18 | Mon Jan 20 | vs Jackson St | W81-73 | 7-11 | .389 | - | | H&PE Arena · Houston, TX |
| 19 | Sat Jan 25 | at Alabama A&M | W82-78 (OT) | 8-11 | .421 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 20 | Mon Jan 27 | at Alabama St | W80-69 | 9-11 | .450 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 21 | Sat Feb 1 | vs Prairie View | W79-63 | 10-11 | .476 | - | | H&PE Arena · Houston, TX |
| 22 | Tue Feb 4 | at AR-Pine Bluff | L68-69 | 10-12 | .455 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 23 | Sat Feb 8 | vs FAMU | L64-66 | 10-13 | .435 | - | | H&PE Arena · Houston, TX |
| 24 | Mon Feb 10 | vs Bethune | L77-80 | 10-14 | .417 | - | | H&PE Arena · Houston, TX |
| 25 | Sat Feb 15 | atGrambling | W67-60 | 11-14 | .440 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 26 | Mon Feb 17 | atSouthern | L57-66 | 11-15 | .423 | - | ESPNU | F. G. Clark Activity Center · Baton Rouge, LA |
