| 1 | Mon Nov 4 | vs Texas So | W78-69 | 1-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 2 | Fri Nov 8 | vs IU Indy | W94-80 | 2-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 3 | Tue Nov 12 | vs Jackson St | W94-57 | 3-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Sat Nov 16 | vs Wake Forest | W75-60 | 4-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 5 | Wed Nov 20 | vs Siena | W80-55 | 5-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 6 | Mon Nov 25 | at South Carolina | W75-66 | 6-0 | 1.000 | #22 | FS1 | Colonial Life Arena · Columbia, SC |
| 7 | Wed Nov 27 | at Michigan | L53-78 | 6-1 | .857 | #22 | FS1 | Crisler Center · Ann Arbor, MI |
| 8 | Sun Dec 1 | vs SC State | W71-68 | 7-1 | .875 | #22 | FS1 | Cintas Center · Cincinnati, OH |
| 9 | Thu Dec 5 | at TCU | L72-76 | 7-2 | .778 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 10 | Tue Dec 10 | vs Morgan St | W119-58 | 8-2 | .800 | - | CBS | Cintas Center · Cincinnati, OH |
| 11 | Sat Dec 14 | at #22Cincinnati | L65-68 | 8-3 | .727 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 12 | Wed Dec 18 | at #11UConn | L89-94 (OT) | 8-4 | .667 | - | FS1 | Gampel Pavilion · Storrs, CT |
| 13 | Sat Dec 21 | vs #9Marquette | L70-72 | 8-5 | .615 | - | FOX | Cintas Center · Cincinnati, OH |
| 14 | Tue Dec 31 | vs Seton Hall | W94-72 | 9-5 | .643 | - | Peacock | Cintas Center · Cincinnati, OH |
| 15 | Fri Jan 3 | at Georgetown | L63-69 | 9-6 | .600 | - | CBS | Capital One Arena · Washington, D.C. |
| 16 | Tue Jan 7 | vs St John's | L72-82 | 9-7 | .563 | - | FS1 | Cintas Center · Cincinnati, OH |
| 17 | Sat Jan 11 | at DePaul | W77-63 | 10-7 | .588 | - | FS1 | Wintrust Arena · Chicago, IL |
| 18 | Tue Jan 14 | vs Villanova | W69-63 | 11-7 | .611 | - | FS1 | Cintas Center · Cincinnati, OH |
| 19 | Sat Jan 18 | at#7Marquette | W59-57 | 12-7 | .632 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 20 | Wed Jan 22 | at#20St John's | L71-79 (OT) | 12-8 | .600 | - | FS1 | Carnesecca Arena · Queens, NY |
| 21 | Sat Jan 25 | vs#19UConn | W76-72 | 13-8 | .619 | - | FOX | Cintas Center · Cincinnati, OH |
| 22 | Wed Jan 29 | at Creighton | L77-86 | 13-9 | .591 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 23 | Tue Feb 4 | vsGeorgetown | W74-69 | 14-9 | .609 | - | FS1 | Cintas Center · Cincinnati, OH |
| 24 | Sun Feb 9 | atVillanova | L68-80 | 14-10 | .583 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 25 | Wed Feb 12 | at Providence | W91-82 | 15-10 | .600 | - | Peacock | Amica Mutual Pavilion · Providence, RI |
| 26 | Sat Feb 15 | vsDePaul | W85-68 | 16-10 | .615 | - | FS1 | Cintas Center · Cincinnati, OH |
| 27 | Tue Feb 18 | vs Butler | W76-63 | 17-10 | .630 | - | Peacock | Cintas Center · Cincinnati, OH |
