| 1 | Mon Nov 3 | vs Marist | 7:15 PM | 20-10 | .667 | - | | Cintas Center · Cincinnati, OH |
| 2 | Thu Nov 6 | vsLe Moyne | TBD | 9-23 | .281 | - | | Cintas Center · Cincinnati, OH |
| 3 | Mon Nov 10 | vsSanta Clara | TBD | 21-13 | .618 | - | | Cintas Center · Cincinnati, OH |
| 4 | Fri Nov 14 | atIowa | TBD | 17-16 | .515 | - | | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Tue Nov 18 | vsOld Dominion | TBD | 15-20 | .429 | - | | Cintas Center · Cincinnati, OH |
| 6 | Fri Nov 21 | vsGeorgia | 9:00 PM | 20-13 | .606 | - | ESPN2 | Cintas Center · Cincinnati, OH |
| 7 | Fri Nov 28 | vsTexas A&M-CC | TBD | 20-14 | .588 | - | | Cintas Center · Cincinnati, OH |
| 8 | Mon Dec 1 | vsSt Francis PA | TBD | 16-18 | .471 | - | | Cintas Center · Cincinnati, OH |
| 9 | Fri Dec 5 | vsCincinnati | 7:30 PM | 19-16 | .543 | - | | Cintas Center · Cincinnati, OH |
| 10 | Fri Dec 12 | vsMissouri St | TBD | 9-23 | .281 | - | | Cintas Center · Cincinnati, OH |
| 11 | Wed Dec 17 | vs#23Creighton | TBD | 25-11 | .694 | - | | Cintas Center · Cincinnati, OH |
| 12 | Sat Dec 20 | atGeorgetown | TBD | 18-16 | .529 | - | | Capital One Arena · Washington, D.C. |
| 13 | Wed Dec 31 | vs#4UConn | 5:00 PM | 24-11 | .686 | - | | Cintas Center · Cincinnati, OH |
| 14 | Sat Jan 3 | atDePaul | TBD | 14-20 | .412 | - | | Wintrust Arena · Chicago, IL |
| 15 | Wed Jan 7 | atMarquette | TBD | 23-11 | .676 | - | | Fiserv Forum · Milwaukee, WI |
| 16 | Sat Jan 10 | vsProvidence | TBD | 12-20 | .375 | - | | Cintas Center · Cincinnati, OH |
| 17 | Wed Jan 14 | vsButler | TBD | 15-20 | .429 | - | | Cintas Center · Cincinnati, OH |
| 18 | Wed Jan 21 | at#23Creighton | TBD | 25-11 | .694 | - | | CHI Health Center Omaha · Omaha, NE |
| 19 | Sat Jan 24 | vs#5St John's | TBD | 31-5 | .861 | - | | Cintas Center · Cincinnati, OH |
| 20 | Wed Jan 28 | atSeton Hall | TBD | 7-25 | .219 | - | | Prudential Center · Newark, NJ |
| 21 | Sat Jan 31 | vsDePaul | TBD | 14-20 | .412 | - | | Cintas Center · Cincinnati, OH |
| 22 | Tue Feb 3 | at#4UConn | 7:00 PM | 24-11 | .686 | - | | Gampel Pavilion · Storrs, CT |
| 23 | Mon Feb 9 | at#5St John's | TBD | 31-5 | .861 | - | | Carnesecca Arena · Queens, NY |
| 24 | Sat Feb 14 | vsMarquette | TBD | 23-11 | .676 | - | | Cintas Center · Cincinnati, OH |
| 25 | Tue Feb 17 | vsVillanova | TBD | 21-15 | .583 | - | | Cintas Center · Cincinnati, OH |
| 26 | Sat Feb 21 | atButler | TBD | 15-20 | .429 | - | | Hinkle Fieldhouse · Indianapolis, IN |
| 27 | Tue Feb 24 | atProvidence | TBD | 12-20 | .375 | - | | Amica Mutual Pavilion · Providence, RI |
| 28 | Sat Feb 28 | vsGeorgetown | TBD | 18-16 | .529 | - | | Cintas Center · Cincinnati, OH |
| 29 | Tue Mar 3 | vsSeton Hall | TBD | 7-25 | .219 | - | | Cintas Center · Cincinnati, OH |
| 30 | Sat Mar 7 | atVillanova | TBD | 21-15 | .583 | - | | Finneran Pavilion · Villanova, PA |
