| 1 | Wed Nov 25 | vs Oakland | W101-49 | 1-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 2 | Thu Nov 26 | vsBradley | W51-50 | 2-0 | 1.000 | - | | Cintas Center · Cincinnati, OH |
| 3 | Fri Nov 27 | vsToledo | W76-73 | 3-0 | 1.000 | - | | Cintas Center · Cincinnati, OH |
| 4 | Mon Nov 30 | vsE Kentucky | W99-96 (OT) | 4-0 | 1.000 | - | | Cintas Center · Cincinnati, OH |
| 5 | Wed Dec 2 | vsTennessee Tech | W79-48 | 5-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 6 | Sun Dec 6 | atCincinnati | W77-69 | 6-0 | 1.000 | - | ESPN | Fifth Third Arena · Cincinnati, OH |
| 7 | Wed Dec 9 | vsOklahoma | W99-77 | 7-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 8 | Sat Dec 12 | atProvidence | PPD | 13-8 | .619 | - | | Amica Mutual Pavilion · Providence, RI |
| 9 | Tue Dec 15 | vsSeton Hall | PPD | 13-8 | .619 | - | FS1 | Cintas Center · Cincinnati, OH |
| 11 | Sun Dec 20 | vsMarquette | W91-88 | 8-0 | 1.000 | - | FS1 | Cintas Center · Cincinnati, OH |
| 12 | Wed Dec 23 | at13Creighton | L61-66 | 8-1 | .889 | #22 | FS1 | CHI Health Center Omaha · Omaha, NE |
| 13 | Wed Dec 30 | vsSeton Hall | L68-85 | 8-2 | .800 | - | FS1 | Cintas Center · Cincinnati, OH |
| 15 | Wed Jan 6 | vsSt John's | W69-61 | 9-2 | .818 | - | CBSSN | Cintas Center · Cincinnati, OH |
| 16 | Sun Jan 10 | vsProvidence | W74-73 | 10-2 | .833 | - | FOX | Cintas Center · Cincinnati, OH |
| 21 | Fri Jan 29 | atButler | PPD | 13-8 | .619 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 22 | Sat Jan 30 | atButler | W68-55 | 11-2 | .846 | - | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 24 | Thu Feb 11 | vsDePaul | PPD | 13-8 | .619 | - | FS1 | Cintas Center · Cincinnati, OH |
| 25 | Sat Feb 13 | vsUConn | L72-80 | 11-3 | .786 | - | FOX | Cintas Center · Cincinnati, OH |
| 26 | Tue Feb 16 | atSt John's | L84-93 | 11-4 | .733 | - | FS1 | Carnesecca Arena · Queens, NY |
| 27 | Sun Feb 21 | vsButler | W63-51 | 12-4 | .750 | - | | Cintas Center · Cincinnati, OH |
| 28 | Wed Feb 24 | atProvidence | L68-83 | 12-5 | .706 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 29 | Sat Feb 27 | vs13Creighton | W77-69 | 13-5 | .722 | - | FOX | Cintas Center · Cincinnati, OH |
| 30 | Tue Mar 2 | atGeorgetown | L66-72 | 13-6 | .684 | - | FS1 | Capital One Arena · Washington, D.C. |
| 31 | Sat Mar 6 | atMarquette | L59-66 | 13-7 | .650 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 32 | Wed Mar 10 | vsButler | L69-70 (OT) | 13-8 | .619 | - | FS1 | Cintas Center · Cincinnati, OH |
