| 1 | Tue Nov 5 | vs Jacksonville | W76-57 | 1-0 | 1.000 | #19 | FS2 | Cintas Center · Cincinnati, OH |
| 2 | Fri Nov 8 | vsSiena | W81-63 | 2-0 | 1.000 | #19 | | Cintas Center · Cincinnati, OH |
| 3 | Tue Nov 12 | vsMissouri | W63-58 (OT) | 3-0 | 1.000 | #21 | CBSSN | Cintas Center · Cincinnati, OH |
| 4 | Fri Nov 15 | vsMissouri St | W59-56 | 4-0 | 1.000 | #21 | | Cintas Center · Cincinnati, OH |
| 5 | Thu Nov 21 | atTowson | W73-51 | 5-0 | 1.000 | - | ESPNU | TD Arena · Charleston, SC |
| 6 | Fri Nov 22 | atUConn | W75-74 (2OT) | 6-0 | 1.000 | - | ESPNU | TD Arena · Charleston, SC |
| 7 | Sun Nov 24 | vsFlorida | L65-70 | 6-1 | .857 | - | ESPN | TD Arena · Charleston, SC |
| 8 | Sat Nov 30 | vsLipscomb | W87-62 | 7-1 | .875 | #25 | | Cintas Center · Cincinnati, OH |
| 9 | Wed Dec 4 | vsGreen Bay | W84-71 | 8-1 | .889 | - | FS2 | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 7 | vsCincinnati | W73-66 | 9-1 | .900 | - | FS1 | Cintas Center · Cincinnati, OH |
| 11 | Sat Dec 14 | atWake Forest | L78-80 | 9-2 | .818 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 12 | Wed Dec 18 | vsW Carolina | W74-61 | 10-2 | .833 | - | FS1 | Cintas Center · Cincinnati, OH |
| 13 | Sun Dec 22 | atTCU | W67-59 | 11-2 | .846 | - | ESPN2 | Schollmaier Arena · Fort Worth, TX |
| 14 | Mon Dec 30 | at10Villanova | L62-68 | 11-3 | .786 | - | FS1 | Finneran Pavilion · Villanova, PA |
| 15 | Sun Jan 5 | vsSt John's | W75-67 | 12-3 | .800 | - | FOX | Cintas Center · Cincinnati, OH |
| 16 | Wed Jan 8 | vsSeton Hall | L71-83 | 12-4 | .750 | - | FS1 | Cintas Center · Cincinnati, OH |
| 17 | Sat Jan 11 | vsCreighton | L65-77 | 12-5 | .706 | - | FOX | Cintas Center · Cincinnati, OH |
| 18 | Wed Jan 15 | atMarquette | L65-85 | 12-6 | .667 | - | | Fiserv Forum · Milwaukee, WI |
| 19 | Wed Jan 22 | vsGeorgetown | W66-57 | 13-6 | .684 | - | FS1 | Cintas Center · Cincinnati, OH |
| 20 | Sun Jan 26 | atCreighton | L66-77 | 13-7 | .650 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 21 | Wed Jan 29 | vsMarquette | L82-84 (2OT) | 13-8 | .619 | - | FS1 | Cintas Center · Cincinnati, OH |
| 22 | Sat Feb 1 | at10Seton Hall | W74-62 | 14-8 | .636 | - | FOX | Prudential Center · Newark, NJ |
| 23 | Tue Feb 4 | atDePaul | W67-59 | 15-8 | .652 | - | FS1 | Wintrust Arena · Chicago, IL |
| 24 | Sat Feb 8 | vsProvidence | W64-58 | 16-8 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 25 | Wed Feb 12 | at19Butler | L61-66 | 16-9 | .640 | - | CBSSN | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Mon Feb 17 | atSt John's | W77-74 | 17-9 | .654 | - | FS1 | Carnesecca Arena · Queens, NY |
| 27 | Sat Feb 22 | vs12Villanova | L55-64 | 17-10 | .630 | - | FOX | Cintas Center · Cincinnati, OH |
| 28 | Tue Feb 25 | vsDePaul | W78-67 | 18-10 | .643 | - | CBSSN | Cintas Center · Cincinnati, OH |
| 29 | Sun Mar 1 | atGeorgetown | W66-63 | 19-10 | .655 | - | CBS | Capital One Arena · Washington, D.C. |
| 30 | Wed Mar 4 | atProvidence | L74-80 | 19-11 | .633 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 31 | Sat Mar 7 | vsButler | L71-72 | 19-12 | .613 | - | FS1 | Cintas Center · Cincinnati, OH |
| 32 | Wed Mar 11 | vsDePaul | L67-71 | 19-13 | .594 | - | FS1 | Cintas Center · Cincinnati, OH |
