| 1 | Mon Nov 7 | vs Morgan St | W96-73 | 1-0 | 1.000 | - | | Cintas Center · Cincinnati, OH |
| 2 | Fri Nov 11 | vs Montana | W86-64 | 2-0 | 1.000 | - | FS2 | Cintas Center · Cincinnati, OH |
| 3 | Tue Nov 15 | vs Fairfield | W78-65 | 3-0 | 1.000 | - | FS2 | Cintas Center · Cincinnati, OH |
| 4 | Fri Nov 18 | vs Indiana | L79-81 | 3-1 | .750 | - | FS1 | Cintas Center · Cincinnati, OH |
| 5 | Thu Nov 24 | vs Florida | W90-83 | 4-1 | .800 | - | ESPN2 | Cintas Center · Cincinnati, OH |
| 6 | Fri Nov 25 | vs Duke | L64-71 | 4-2 | .667 | - | ESPN | Cintas Center · Cincinnati, OH |
| 7 | Sun Nov 27 | at Gonzaga | L84-88 | 4-3 | .571 | - | ESPN | McCarthey Athletic Center · Spokane, WA |
| 8 | Wed Nov 30 | vs SE Louisiana | W95-63 | 5-3 | .625 | - | FS1 | Cintas Center · Cincinnati, OH |
| 9 | Sat Dec 3 | vs West Virginia | W84-74 | 6-3 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 10 | at Cincinnati | W80-77 | 7-3 | .700 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 11 | Tue Dec 13 | vs Southern | W79-59 | 8-3 | .727 | - | FS1 | Cintas Center · Cincinnati, OH |
| 12 | Fri Dec 16 | at Georgetown | W102-89 | 9-3 | .750 | - | FS1 | Capital One Arena · Washington, D.C. |
| 13 | Tue Dec 20 | vs Seton Hall | W73-70 | 10-3 | .769 | - | FS1 | Cintas Center · Cincinnati, OH |
| 14 | Wed Dec 28 | at St John's | W84-79 | 11-3 | .786 | #22 | FS1 | Carnesecca Arena · Queens, NY |
| 15 | Sat Dec 31 | vs #2UConn | W83-73 | 12-3 | .800 | #22 | FOX | Cintas Center · Cincinnati, OH |
| 16 | Sat Jan 7 | at Villanova | W88-80 | 13-3 | .813 | #18 | FS1 | Finneran Pavilion · Villanova, PA |
| 17 | Wed Jan 11 | vs Creighton | W90-87 | 14-3 | .824 | #12 | FS1 | Cintas Center · Cincinnati, OH |
| 18 | Sun Jan 15 | vs #25Marquette | W80-76 | 15-3 | .833 | #12 | FOX | Cintas Center · Cincinnati, OH |
| 19 | Wed Jan 18 | at DePaul | L72-73 | 15-4 | .789 | #8 | FS1 | Wintrust Arena · Chicago, IL |
| 20 | Sat Jan 21 | vsGeorgetown | W95-82 | 16-4 | .800 | #8 | FS1 | Cintas Center · Cincinnati, OH |
| 21 | Wed Jan 25 | at#19UConn | W82-79 | 17-4 | .810 | #13 | FS1 | Gampel Pavilion · Storrs, CT |
| 22 | Sat Jan 28 | atCreighton | L67-84 | 17-5 | .773 | #13 | CBS | CHI Health Center Omaha · Omaha, NE |
| 23 | Wed Feb 1 | vs #17Providence | W85-83 (OT) | 18-5 | .783 | #16 | FS1 | Cintas Center · Cincinnati, OH |
| 24 | Sat Feb 4 | vsSt John's | W96-71 | 19-5 | .792 | #16 | FOX | Cintas Center · Cincinnati, OH |
| 25 | Fri Feb 10 | at Butler | L67-69 | 19-6 | .760 | #13 | FS1 | Hinkle Fieldhouse · Indianapolis, IN |
| 26 | Wed Feb 15 | at#11Marquette | L68-69 | 19-7 | .731 | #16 | CBS | Fiserv Forum · Milwaukee, WI |
| 27 | Sat Feb 18 | vsDePaul | W82-68 | 20-7 | .741 | #16 | CBS | Cintas Center · Cincinnati, OH |
| 28 | Tue Feb 21 | vsVillanova | L63-64 | 20-8 | .714 | #16 | FS1 | Cintas Center · Cincinnati, OH |
| 29 | Fri Feb 24 | atSeton Hall | W82-60 | 21-8 | .724 | #16 | FS1 | Prudential Center · Newark, NJ |
| 30 | Wed Mar 1 | at#20Providence | W94-89 | 22-8 | .733 | #19 | FS1 | Amica Mutual Pavilion · Providence, RI |
| 31 | Sat Mar 4 | vsButler | W78-66 | 23-8 | .742 | #19 | FS1 | Cintas Center · Cincinnati, OH |
| 32 | Thu Mar 9 | vsDePaul | W89-84 | 24-8 | .750 | - | FS1 | Cintas Center · Cincinnati, OH |
| 33 | Fri Mar 10 | vsCreighton | W82-60 | 25-8 | .758 | - | FS1 | Cintas Center · Cincinnati, OH |
| 34 | Sat Mar 11 | atMarquette | L51-65 | 25-9 | .735 | - | FOX | Fiserv Forum · Milwaukee, WI |
| 35 | Fri Mar 17 | vs #14Kennesaw St | W72-67 | 26-9 | .743 | #3 | truTV | Cintas Center · Cincinnati, OH |
| 36 | Sun Mar 19 | vs #11Pitt | W84-73 | 27-9 | .750 | #3 | CBS | Cintas Center · Cincinnati, OH |
| 37 | Fri Mar 24 | at #2Texas | L71-83 | 27-10 | .730 | #3 | CBS | Moody Center · Austin, TX |
