| 1 | Mon Nov 4 | vs #8Baylor | W101-63 | 1-0 | 1.000 | #6 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 2 | Sun Nov 10 | vs Arizona St | W88-80 | 2-0 | 1.000 | #6 | ESPN | McCarthey Athletic Center · Spokane, WA |
| 3 | Fri Nov 15 | vs UMass Lowell | W113-54 | 3-0 | 1.000 | #4 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 4 | Mon Nov 18 | at SDSU | W80-67 | 4-0 | 1.000 | #3 | CBS | Viejas Arena · San Diego, CA |
| 5 | Wed Nov 20 | vs Long Beach St | W84-41 | 5-0 | 1.000 | #3 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 6 | Wed Nov 27 | at West Virginia | L78-86 (OT) | 5-1 | .833 | #3 | ESPN | WVU Coliseum · Morgantown, WV |
| 7 | Thu Nov 28 | at #14Indiana | W89-73 | 6-1 | .857 | #3 | ESPN2 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Fri Nov 29 | vs Davidson | W90-65 | 7-1 | .875 | #3 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 9 | Sat Dec 7 | vs #4Kentucky | L89-90 (OT) | 7-2 | .778 | #7 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 10 | Sat Dec 14 | at #18UConn | L71-77 | 7-3 | .700 | #8 | FOX | Gampel Pavilion · Storrs, CT |
| 11 | Wed Dec 18 | vs Nicholls | W102-72 | 8-3 | .727 | #13 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 12 | Sat Dec 21 | vs Bucknell | W86-65 | 9-3 | .750 | #13 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 13 | Sat Dec 28 | at #22UCLA | L62-65 | 9-4 | .692 | #14 | FOX | Pauley Pavilion · Los Angeles, CA |
| 14 | Mon Dec 30 | at Pepperdine | W89-82 | 10-4 | .714 | #19 | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 15 | Thu Jan 2 | vs Portland | W81-50 | 11-4 | .733 | #19 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 16 | Sat Jan 4 | at LMU | W96-68 | 12-4 | .750 | #19 | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 17 | Wed Jan 8 | vs San Diego | W93-80 | 13-4 | .765 | #18 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 18 | Sat Jan 11 | vs Washington St | W88-75 | 14-4 | .778 | #18 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 19 | Thu Jan 16 | at Oregon St | L89-97 (OT) | 14-5 | .737 | #16 | CBS | Gill Coliseum · Corvallis, OR |
| 20 | Sat Jan 18 | vs Santa Clara | L99-103 | 14-6 | .700 | #16 | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 21 | Sat Jan 25 | atPortland | W105-62 | 15-6 | .714 | - | ESPN+ | Chiles Center · Portland, OR |
| 22 | Tue Jan 28 | vsOregon St | W98-60 | 16-6 | .727 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 23 | Sat Feb 1 | at Saint Mary's | L58-62 | 16-7 | .696 | - | ESPN | University Credit Union Pavilion · Moraga, CA |
| 24 | Thu Feb 6 | vsLMU | W73-53 | 17-7 | .708 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 25 | Sat Feb 8 | at Pacific | W78-61 | 18-7 | .720 | - | ESPN+ | Alex G. Spanos Center · Stockton, CA |
| 26 | Thu Feb 13 | vs San Francisco | W88-77 | 19-7 | .731 | - | ESPN | McCarthey Athletic Center · Spokane, WA |
| 27 | Sat Feb 15 | vsPepperdine | W107-55 | 20-7 | .741 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 28 | Wed Feb 19 | atWashington St | W84-63 | 21-7 | .750 | - | ESPN2 | Friel Court at Beasley Coliseum · Pullman, WA |
