| 1 | Fri Nov 10 | vs Yale | W86-71 | 1-0 | 1.000 | #11 | | McCarthey Athletic Center · Spokane, WA |
| 2 | Tue Nov 14 | vs TBD | W123-57 | 2-0 | 1.000 | #11 | | McCarthey Athletic Center · Spokane, WA |
| 3 | Mon Nov 20 | vs #2Purdue | L63-73 | 2-1 | .667 | #11 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 4 | Tue Nov 21 | vs Syracuse | W76-57 | 3-1 | .750 | #11 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 5 | Wed Nov 22 | at UCLA | W69-65 | 4-1 | .800 | #11 | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 6 | Tue Nov 28 | vs Bakersfield | W81-65 | 5-1 | .833 | #11 | | McCarthey Athletic Center · Spokane, WA |
| 7 | Sat Dec 2 | at USC | W89-76 | 6-1 | .857 | #11 | ESPN | Galen Center · Los Angeles, CA |
| 8 | Tue Dec 5 | vs AR-Pine Bluff | W111-71 | 7-1 | .875 | #7 | | McCarthey Athletic Center · Spokane, WA |
| 9 | Sat Dec 9 | at Washington | L73-78 | 7-2 | .778 | #7 | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 10 | Mon Dec 11 | vs Miss Valley St | W78-40 | 8-2 | .800 | #10 | | McCarthey Athletic Center · Spokane, WA |
| 11 | Fri Dec 15 | vs #5UConn | L63-76 | 8-3 | .727 | #10 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 12 | Wed Dec 20 | vs Jackson St | W100-76 | 9-3 | .750 | #15 | | McCarthey Athletic Center · Spokane, WA |
| 13 | Fri Dec 29 | vs SDSU | L74-84 | 9-4 | .692 | #13 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 14 | Thu Jan 4 | vs Pepperdine | W86-60 | 10-4 | .714 | #24 | | McCarthey Athletic Center · Spokane, WA |
| 15 | Sat Jan 6 | vs San Diego | W101-74 | 11-4 | .733 | #24 | | McCarthey Athletic Center · Spokane, WA |
| 16 | Thu Jan 11 | at Santa Clara | L76-77 | 11-5 | .688 | #23 | ESPN | Leavey Center · Santa Clara, CA |
| 17 | Thu Jan 18 | atPepperdine | W86-61 | 12-5 | .706 | - | | Firestone Fieldhouse · Malibu, CA |
| 18 | Sat Jan 20 | atSan Diego | W105-63 | 13-5 | .722 | - | | Jenny Craig Pavilion · San Diego, CA |
| 19 | Thu Jan 25 | vs San Francisco | W77-72 | 14-5 | .737 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 20 | Sat Jan 27 | at Pacific | W82-73 | 15-5 | .750 | - | | Alex G. Spanos Center · Stockton, CA |
| 21 | Tue Jan 30 | vs LMU | W92-58 | 16-5 | .762 | - | ESPN | McCarthey Athletic Center · Spokane, WA |
| 22 | Sat Feb 3 | vs Saint Mary's | L62-64 | 16-6 | .727 | - | ESPN | McCarthey Athletic Center · Spokane, WA |
| 23 | Wed Feb 7 | vs Portland | W96-64 | 17-6 | .739 | - | CBS | McCarthey Athletic Center · Spokane, WA |
| 24 | Sat Feb 10 | at #17Kentucky | W89-85 | 18-6 | .750 | - | CBS | Rupp Arena · Lexington, KY |
| 25 | Thu Feb 15 | atLMU | W91-74 | 19-6 | .760 | - | CBS | Gersten Pavilion · Los Angeles, CA |
| 26 | Sat Feb 17 | vsPacific | W102-76 | 20-6 | .769 | - | | McCarthey Athletic Center · Spokane, WA |
| 27 | Thu Feb 22 | atPortland | W86-65 | 21-6 | .778 | - | | Chiles Center · Portland, OR |
| 28 | Sat Feb 24 | vsSanta Clara | W94-81 | 22-6 | .786 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 29 | Thu Feb 29 | atSan Francisco | W86-68 | 23-6 | .793 | #23 | ESPN2 | War Memorial at the Sobrato Center · San Francisco, CA |
| 30 | Sat Mar 2 | at#17Saint Mary's | W70-57 | 24-6 | .800 | #23 | ESPN | University Credit Union Pavilion · Moraga, CA |
| 31 | Mon Mar 11 | vsSan Francisco | W89-77 | 25-6 | .806 | #17 | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 32 | Tue Mar 12 | at#21Saint Mary's | L60-69 | 25-7 | .781 | #17 | ESPN | University Credit Union Pavilion · Moraga, CA |
| 33 | Thu Mar 21 | vs #12McNeese | W86-65 | 26-7 | .788 | #5 | TBS | McCarthey Athletic Center · Spokane, WA |
| 34 | Sat Mar 23 | at #4Kansas | W89-68 | 27-7 | .794 | #5 | CBS | Allen Fieldhouse · Lawrence, KS |
| 35 | Fri Mar 29 | at#1Purdue | L68-80 | 27-8 | .771 | #5 | TBS | Mackey Arena · West Lafayette, IN |
