| 1 | Mon Nov 3 | vs AR-Pine Bluff | W94-50 | 1-0 | 1.000 | - | B1G+ | Alaska Airlines Arena · Seattle, WA |
| 2 | Thu Nov 6 | vsDenver | W84-70 | 2-0 | 1.000 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 3 | Sun Nov 9 | atBaylor | L69-78 | 2-1 | .667 | - | ESPN | Ferrell Center · Waco, TX |
| 4 | Fri Nov 14 | atWashington St | W81-69 | 3-1 | .750 | - | ESPN+ | Friel Court at Beasley Coliseum · Pullman, WA |
| 5 | Tue Nov 18 | vsSouthern | W99-93 (2OT) | 4-1 | .800 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 6 | Thu Nov 27 | vsNevada | W83-66 | 5-1 | .833 | - | CBSSN | Alaska Airlines Arena · Seattle, WA |
| 7 | Fri Nov 28 | atColorado | L68-81 | 5-2 | .714 | - | truTV | CU Events Center · Boulder, CO |
| 8 | Wed Dec 3 | vsUCLA | L80-82 | 5-3 | .625 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 9 | Sat Dec 6 | at24USC | W84-76 | 6-3 | .667 | - | BTN | Galen Center · Los Angeles, CA |
| 10 | Sat Dec 13 | vsSouthern Utah | W105-69 | 7-3 | .700 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 11 | Fri Dec 19 | atSeattle U | L66-70 | 7-4 | .636 | - | ESPN2 | Redhawk Center · Seattle, WA |
| 12 | Mon Dec 22 | vsSan Diego | W86-56 | 8-4 | .667 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 13 | Mon Dec 29 | vsUtah | W74-65 | 9-4 | .692 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 14 | Sun Jan 4 | atIndiana | L80-90 | 9-5 | .643 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 15 | Wed Jan 7 | at5Purdue | L73-81 | 9-6 | .600 | - | BTN | Mackey Arena · West Lafayette, IN |
| 16 | Sun Jan 11 | vsOhio State | W81-74 | 10-6 | .625 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 17 | Wed Jan 14 | vs4Michigan | L72-82 | 10-7 | .588 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 18 | Sat Jan 17 | vs12Michigan St | L63-80 | 10-8 | .556 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 19 | Wed Jan 21 | at7Nebraska | L66-76 | 10-9 | .526 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 20 | Sun Jan 25 | vsOregon | W72-57 | 11-9 | .550 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 21 | Thu Jan 29 | at9Illinois | L66-75 | 11-10 | .524 | - | FS1 | State Farm Center · Champaign, IL |
| 22 | Sat Jan 31 | atNorthwestern | W76-62 | 12-10 | .545 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 23 | Wed Feb 4 | vsIowa | L74-84 | 12-11 | .522 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 24 | Sat Feb 7 | atUCLA | L73-77 | 12-12 | .500 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 25 | Wed Feb 11 | vsPenn State | L60-63 | 12-13 | .480 | - | BTN | Alaska Airlines Arena · Seattle, WA |
| 26 | Sat Feb 14 | vsMinnesota | W69-57 | 13-13 | .500 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 27 | Sat Feb 21 | atMaryland | L60-64 | 13-14 | .481 | - | Peacock | XFINITY Center · College Park, MD |
| 28 | Tue Feb 24 | atRutgers | W79-72 | 14-14 | .500 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 29 | Sat Feb 28 | vsWisconsin | L73-90 | 14-15 | .483 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
