| 4 | Sun Nov 29 | at 2Baylor | L52-86 | 0-1 | .000 | - | | T-Mobile Arena · Las Vegas, NV |
| 5 | Tue Dec 1 | vsUC Riverside | L42-57 | 0-2 | .000 | - | | T-Mobile Arena · Las Vegas, NV |
| 6 | Thu Dec 3 | atUtah | L62-76 | 0-3 | .000 | - | | Jon M. Huntsman Center · Salt Lake City, UT |
| 7 | Wed Dec 9 | vsSeattle U | W73-41 | 1-3 | .250 | - | | Alaska Airlines Arena · Seattle, WA |
| 8 | Sat Dec 12 | vsOregon | L71-74 | 1-4 | .200 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 9 | Wed Dec 16 | vsMontana | L58-66 | 1-5 | .167 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 10 | Sun Dec 20 | atColorado | L69-92 | 1-6 | .143 | - | PACN | T-Mobile Arena · Las Vegas, NV |
| 11 | Thu Dec 31 | vsArizona | L53-80 | 1-7 | .125 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 13 | Thu Jan 7 | atStanford | L75-91 | 1-8 | .111 | - | FS1 | Maples Pavilion · Stanford, CA |
| 14 | Sat Jan 9 | atCalifornia | L78-84 | 1-9 | .100 | - | PACN | Haas Pavilion · Berkeley, CA |
| 15 | Thu Jan 14 | atUSC | L68-95 | 1-10 | .091 | - | PACN | Galen Center · Los Angeles, CA |
| 16 | Sat Jan 16 | atUCLA | L76-81 | 1-11 | .083 | - | PACN | Pauley Pavilion · Los Angeles, CA |
| 17 | Wed Jan 20 | vsColorado | W84-80 | 2-11 | .154 | - | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 18 | Sun Jan 24 | vsUtah | W83-79 | 3-11 | .214 | - | ESPNU | Alaska Airlines Arena · Seattle, WA |
| 19 | Sun Jan 31 | vsWashington St | L62-77 | 3-12 | .200 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 20 | Thu Feb 4 | atOregon St | L71-91 | 3-13 | .188 | - | PACN | Gill Coliseum · Corvallis, OR |
| 21 | Sat Feb 6 | atOregon | L74-86 | 3-14 | .176 | - | CBS | Matthew Knight Arena · Eugene, OR |
| 22 | Thu Feb 11 | vs20USC | L54-69 | 3-15 | .167 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 23 | Sat Feb 13 | vsUCLA | L61-64 | 3-16 | .158 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 24 | Mon Feb 15 | atWashington St | W65-63 | 4-16 | .200 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 25 | Thu Feb 18 | vsStanford | L61-79 | 4-17 | .190 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 26 | Sat Feb 20 | vsCalifornia | W62-51 | 5-17 | .227 | - | ESPNU | Alaska Airlines Arena · Seattle, WA |
| 27 | Tue Feb 23 | atArizona St | L64-97 | 5-18 | .217 | - | PACN | Desert Financial Arena · Tempe, AZ |
| 28 | Thu Feb 25 | atArizona St | L72-80 | 5-19 | .208 | - | FS1 | Desert Financial Arena · Tempe, AZ |
| 29 | Sat Feb 27 | atArizona | L74-75 | 5-20 | .200 | - | CBS | McKale Center · Tucson, AZ |
| 30 | Wed Mar 10 | atUtah | L95-98 | 5-21 | .192 | - | PACN | T-Mobile Arena · Las Vegas, NV |
