| 1 | Fri Nov 8 | at Baylor | W67-64 | 1-0 | 1.000 | - | ESPN | Ferrell Center · Waco, TX |
| 2 | Tue Nov 12 | vs Mount St Mary | W56-46 | 2-0 | 1.000 | #20 | PACN | Alaska Airlines Arena · Seattle, WA |
| 3 | Sat Nov 16 | at Tennessee | L62-75 | 2-1 | .667 | - | | Thompson-Boling Arena · Knoxville, TN |
| 4 | Tue Nov 19 | vs Maine | W72-53 | 3-1 | .750 | #25 | PACN | Alaska Airlines Arena · Seattle, WA |
| 5 | Fri Nov 22 | vs Montana | W73-56 | 4-1 | .800 | #25 | PACN | Alaska Airlines Arena · Seattle, WA |
| 6 | Sun Nov 24 | vs San Diego | W88-69 | 5-1 | .833 | #25 | PACN | Alaska Airlines Arena · Seattle, WA |
| 7 | Mon Dec 2 | vs South Dakota | W75-55 | 6-1 | .857 | #22 | PACN | Alaska Airlines Arena · Seattle, WA |
| 8 | Wed Dec 4 | vs E Washington | W90-80 | 7-1 | .875 | #22 | | Alaska Airlines Arena · Seattle, WA |
| 9 | Sun Dec 8 | vs #9Gonzaga | L76-83 | 7-2 | .778 | #22 | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 10 | Tue Dec 17 | vs Seattle U | W81-59 | 8-2 | .800 | #22 | PACN | Alaska Airlines Arena · Seattle, WA |
| 11 | Sun Dec 22 | vs Ball State | W85-64 | 9-2 | .818 | - | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 12 | Mon Dec 23 | at Hawai'i | W72-61 | 10-2 | .833 | - | ESPN2 | Stan Sheriff Center · Honolulu, HI |
| 13 | Wed Dec 25 | vs Houston | L71-75 | 10-3 | .769 | - | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 14 | Thu Jan 2 | vs UCLA | L64-66 | 10-4 | .714 | - | | Alaska Airlines Arena · Seattle, WA |
| 15 | Sun Jan 5 | vs USC | W72-40 | 11-4 | .733 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 16 | Thu Jan 9 | at Stanford | L55-61 | 11-5 | .688 | - | FS1 | Maples Pavilion · Stanford, CA |
| 17 | Sat Jan 11 | at California | L58-61 (OT) | 11-6 | .647 | - | PACN | Haas Pavilion · Berkeley, CA |
| 18 | Thu Jan 16 | vs Oregon St | W64-56 | 12-6 | .667 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 19 | Sat Jan 18 | vs #8Oregon | L61-64 (OT) | 12-7 | .632 | - | CBS | Alaska Airlines Arena · Seattle, WA |
| 20 | Thu Jan 23 | at Utah | L66-67 | 12-8 | .600 | - | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 21 | Sat Jan 25 | at #23Colorado | L62-76 | 12-9 | .571 | - | FS1 | CU Events Center · Boulder, CO |
| 22 | Thu Jan 30 | vs Arizona | L72-75 | 12-10 | .545 | - | ESPN2 | Alaska Airlines Arena · Seattle, WA |
| 23 | Sat Feb 1 | vs Arizona St | L83-87 | 12-11 | .522 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 24 | Sun Feb 9 | at Washington St | L67-79 | 12-12 | .500 | - | ESPNU | Friel Court at Beasley Coliseum · Pullman, WA |
| 25 | Thu Feb 13 | atUSC | L56-62 | 12-13 | .480 | - | ESPN2 | Galen Center · Los Angeles, CA |
| 26 | Sat Feb 15 | atUCLA | L57-67 | 12-14 | .462 | - | ESPN2 | Pauley Pavilion · Los Angeles, CA |
| 27 | Thu Feb 20 | vsStanford | L64-72 | 12-15 | .444 | - | | Alaska Airlines Arena · Seattle, WA |
| 28 | Sat Feb 22 | vsCalifornia | W87-52 | 13-15 | .464 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 29 | Fri Feb 28 | vsWashington St | L74-78 | 13-16 | .448 | - | FS1 | Alaska Airlines Arena · Seattle, WA |
| 30 | Thu Mar 5 | atArizona St | W90-83 | 14-16 | .467 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 31 | Sat Mar 7 | atArizona | W69-63 | 15-16 | .484 | - | ESPN | McKale Center · Tucson, AZ |
| 32 | Wed Mar 11 | atArizona | L70-77 | 15-17 | .469 | - | PACN | McKale Center · Tucson, AZ |
