| 1 | Mon Nov 3 | vs Montana St | W84-78 | 1-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 2 | Sat Nov 8 | vsE Washington | W102-97 (OT) | 2-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 3 | Fri Nov 14 | vsProvidence | W97-88 | 3-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 4 | Mon Nov 17 | vsAlabama St | W94-66 | 4-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 5 | Fri Nov 21 | vsUC Davis | W95-79 | 5-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 6 | Thu Nov 27 | vsSan Francisco | W79-69 | 6-0 | 1.000 | - | CBSSN | CU Events Center · Boulder, CO |
| 7 | Fri Nov 28 | vsWashington | W81-68 | 7-0 | 1.000 | - | truTV | CU Events Center · Boulder, CO |
| 8 | Mon Dec 1 | vsCA Baptist | W78-70 | 8-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 9 | Sat Dec 6 | atColorado St | L86-91 | 8-1 | .889 | - | CBSSN | Moby Arena · Fort Collins, CO |
| 10 | Sat Dec 13 | vsUTSA | W88-64 | 9-1 | .900 | - | ESPN+ | CU Events Center · Boulder, CO |
| 11 | Wed Dec 17 | vsPortland St | W84-73 | 10-1 | .909 | - | ESPN+ | CU Events Center · Boulder, CO |
| 12 | Sat Dec 20 | vsStanford | L68-77 | 10-2 | .833 | - | ESPNU | Mortgage Matchup Center · Phoenix, AZ |
| 13 | Sun Dec 28 | vsN Colorado | L81-86 | 10-3 | .769 | - | ESPN+ | CU Events Center · Boulder, CO |
| 14 | Sat Jan 3 | atArizona St | W95-89 | 11-3 | .786 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 15 | Wed Jan 7 | vsUtah | W85-73 | 12-3 | .800 | - | ESPN+ | CU Events Center · Boulder, CO |
| 16 | Sat Jan 10 | vs14Texas Tech | L71-73 | 12-4 | .750 | - | CBSSN | CU Events Center · Boulder, CO |
| 17 | Wed Jan 14 | atCincinnati | L68-77 | 12-5 | .706 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 17 | atWest Virginia | L61-72 | 12-6 | .667 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 19 | Tue Jan 20 | vs19Kansas | L69-75 | 12-7 | .632 | - | ESPN | CU Events Center · Boulder, CO |
| 20 | Sat Jan 24 | vsUCF | L86-95 | 12-8 | .600 | - | ESPN+ | CU Events Center · Boulder, CO |
| 21 | Thu Jan 29 | at8Iowa State | L67-97 | 12-9 | .571 | - | FS1 | James H. Hilton Coliseum · Ames, IA |
| 22 | Sun Feb 1 | vsTCU | W87-61 | 13-9 | .591 | - | TNT | CU Events Center · Boulder, CO |
| 23 | Wed Feb 4 | atBaylor | L67-86 | 13-10 | .565 | - | Peacock | Ferrell Center · Waco, TX |
| 24 | Sat Feb 7 | vsArizona St | W78-70 | 14-10 | .583 | - | ESPN2 | CU Events Center · Boulder, CO |
| 25 | Wed Feb 11 | at16Texas Tech | L44-78 | 14-11 | .560 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 26 | Sat Feb 14 | at22BYU | L86-90 (OT) | 14-12 | .538 | - | FS1 | Marriott Center · Provo, UT |
| 27 | Sat Feb 21 | vsOklahoma St | W83-69 | 15-12 | .556 | - | TNT | CU Events Center · Boulder, CO |
| 28 | Wed Feb 25 | vsKansas St | W79-70 | 16-12 | .571 | - | FS1 | CU Events Center · Boulder, CO |
| 29 | Sat Feb 28 | at5Houston | L62-102 | 16-13 | .552 | - | ESPN2 | Fertitta Center · Houston, TX |
